A genetically defined tecto-thalamic pathway drives a system of superior-colliculus-dependent visual cortices.
calcium imaging
electrophysiology
extra-geniculate
higher visual areas
mouse
postrhinal cortex
pulvinar
superior colliculus
tecto-thalamic pathway
visual cortex
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
received:
23
06
2022
revised:
13
02
2023
accepted:
17
04
2023
pmc-release:
19
07
2024
medline:
24
7
2023
pubmed:
13
5
2023
entrez:
12
5
2023
Statut:
ppublish
Résumé
Cortical responses to visual stimuli are believed to rely on the geniculo-striate pathway. However, recent work has challenged this notion by showing that responses in the postrhinal cortex (POR), a visual cortical area, instead depend on the tecto-thalamic pathway, which conveys visual information to the cortex via the superior colliculus (SC). Does POR's SC-dependence point to a wider system of tecto-thalamic cortical visual areas? What information might this system extract from the visual world? We discovered multiple mouse cortical areas whose visual responses rely on SC, with the most lateral showing the strongest SC-dependence. This system is driven by a genetically defined cell type that connects the SC to the pulvinar thalamic nucleus. Finally, we show that SC-dependent cortices distinguish self-generated from externally generated visual motion. Hence, lateral visual areas comprise a system that relies on the tecto-thalamic pathway and contributes to processing visual motion as animals move through the environment.
Identifiants
pubmed: 37172584
pii: S0896-6273(23)00307-0
doi: 10.1016/j.neuron.2023.04.022
pmc: PMC10524301
mid: NIHMS1901020
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2247-2257.e7Subventions
Organisme : Intramural NIH HHS
ID : Z01 MH002497
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Wellcome Trust
ID : 222583/Z/21/Z
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS123912
Pays : United States
Organisme : NEI NIH HHS
ID : F31 EY033661
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : ZIA MH002497
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS107613
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M.S. is a member of the advisory board for Neuron.
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