Synaptic logistics: Competing over shared resources.
Competition
Neurodegenerative disorder
Neurologistics
Synapse
Synaptic plasticity
Journal
Molecular and cellular neurosciences
ISSN: 1095-9327
Titre abrégé: Mol Cell Neurosci
Pays: United States
ID NLM: 9100095
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
23
11
2022
revised:
05
05
2023
accepted:
05
05
2023
medline:
5
6
2023
pubmed:
13
5
2023
entrez:
12
5
2023
Statut:
ppublish
Résumé
High turnover rates of synaptic proteins imply that synapses constantly need to replace their constituent building blocks. This requires sophisticated supply chains and potentially exposes synapses to shortages as they compete for limited resources. Interestingly, competition in neurons has been observed at different scales. Whether it is competition of receptors for binding sites inside a single synapse or synapses fighting for resources to grow. Here we review the implications of such competition for synaptic function and plasticity. We identify multiple mechanisms that synapses use to safeguard themselves against supply shortages and identify a fundamental neurologistic trade-off governing the sizes of reserve pools of essential synaptic building blocks.
Identifiants
pubmed: 37172922
pii: S1044-7431(23)00052-0
doi: 10.1016/j.mcn.2023.103858
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103858Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest We declare having no competing interest.