Substrate and phosphorylation site selection by phosphoprotein phosphatases.
kinetochore
mitosis
phosphoprotein phosphatases (PPPs)
phosphorylation site consensus motifs
protein phosphorylation
short linear motif (SLiM)
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
04
01
2023
revised:
11
04
2023
accepted:
13
04
2023
pmc-release:
01
08
2024
medline:
17
7
2023
pubmed:
13
5
2023
entrez:
12
5
2023
Statut:
ppublish
Résumé
Dynamic protein phosphorylation and dephosphorylation are essential regulatory mechanisms that ensure proper cellular signaling and biological functions. Deregulation of either reaction has been implicated in several human diseases. Here, we focus on the mechanisms that govern the specificity of the dephosphorylation reaction. Most cellular serine/threonine dephosphorylation is catalyzed by 13 highly conserved phosphoprotein phosphatase (PPP) catalytic subunits, which form hundreds of holoenzymes by binding to regulatory and scaffolding subunits. PPP holoenzymes recognize phosphorylation site consensus motifs and interact with short linear motifs (SLiMs) or structural elements distal to the phosphorylation site. We review recent advances in understanding the mechanisms of PPP site-specific dephosphorylation preference and substrate recruitment and highlight examples of their interplay in the regulation of cell division.
Identifiants
pubmed: 37173206
pii: S0968-0004(23)00088-9
doi: 10.1016/j.tibs.2023.04.004
pmc: PMC10523993
mid: NIHMS1893214
pii:
doi:
Substances chimiques
Phosphoprotein Phosphatases
EC 3.1.3.16
Holoenzymes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
713-725Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM119455
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
Références
Structure. 2012 Oct 10;20(10):1746-56
pubmed: 22940584
Mol Cell. 2008 Sep 26;31(6):873-85
pubmed: 18922469
Cell Commun Signal. 2015 Dec 01;13:45
pubmed: 26626130
J Cell Biol. 2019 Feb 4;218(2):395-409
pubmed: 30446607
EMBO J. 2009 Sep 16;28(18):2786-93
pubmed: 19680222
Science. 2002 Dec 6;298(5600):1912-34
pubmed: 12471243
Structure. 2007 Dec;15(12):1591-602
pubmed: 18073109
FEBS J. 2013 Jan;280(2):324-45
pubmed: 22519956
Chem Biol. 2012 May 25;19(5):608-18
pubmed: 22633412
Structure. 2016 Dec 6;24(12):2174-2181
pubmed: 27998540
J Cell Sci. 2011 Jul 15;124(Pt 14):2323-34
pubmed: 21709074
Elife. 2016 Aug 30;5:
pubmed: 27572260
Trends Biochem Sci. 2022 Jun;47(6):547-548
pubmed: 35168834
Science. 2010 Dec 17;330(6011):1670-3
pubmed: 21164013
Mol Cell Proteomics. 2016 Jul;15(7):2448-61
pubmed: 27134283
ACS Chem Biol. 2019 Dec 20;14(12):2672-2682
pubmed: 31633908
Sci Signal. 2011 Jun 28;4(179):rs5
pubmed: 21712546
Protein Cell. 2016 Jul;7(7):516-26
pubmed: 27350047
Mol Cell. 2014 Jul 17;55(2):161-9
pubmed: 25038412
FEBS J. 2013 Jan;280(2):584-95
pubmed: 22360570
J Am Chem Soc. 2017 Dec 13;139(49):17703-17706
pubmed: 29156132
Mol Cell. 2016 Aug 18;63(4):686-695
pubmed: 27453045
Mol Cell. 2000 Oct;6(4):873-83
pubmed: 11090625
Nucleic Acids Res. 2019 Jan 8;47(D1):D433-D441
pubmed: 30445427
Mol Cell. 2017 Feb 2;65(3):393-402.e3
pubmed: 28132839
Science. 2009 Sep 25;325(5948):1682-6
pubmed: 19779198
Biochemistry. 2011 Feb 22;50(7):1238-46
pubmed: 21218781
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1311-5
pubmed: 6246487
Nat Biotechnol. 2020 Mar;38(3):365-373
pubmed: 31819260
Chem Biol. 2009 Apr 24;16(4):365-71
pubmed: 19389623
Cell Discov. 2017 Aug 08;3:17027
pubmed: 28884018
Mol Cell. 2020 Jul 16;79(2):342-358.e12
pubmed: 32645368
Elife. 2014 Mar 11;3:e01695
pubmed: 24618897
Elife. 2021 Oct 18;10:
pubmed: 34661528
Cell Rep. 2014 Sep 11;8(5):1583-94
pubmed: 25159151
Adv Cancer Res. 2019;144:55-93
pubmed: 31349904
J Cell Sci. 2013 Mar 1;126(Pt 5):1086-92
pubmed: 23345399
Structure. 2018 Oct 2;26(10):1327-1336.e4
pubmed: 30100357
Annu Rev Biochem. 2018 Jun 20;87:921-964
pubmed: 29925267
Mol Cell. 2019 Dec 19;76(6):953-964.e6
pubmed: 31585692
J Biol Chem. 1987 Jan 25;262(3):1060-4
pubmed: 3027075
Dev Cell. 2012 Oct 16;23(4):745-55
pubmed: 23079597
Mol Cell. 2014 Jan 9;53(1):140-7
pubmed: 24374310
Cell. 2006 Oct 20;127(2):341-53
pubmed: 17055435
Mol Biol Cell. 1993 Jul;4(7):669-77
pubmed: 8400454
Cell Commun Signal. 2015 Nov 21;13:43
pubmed: 26589632
Curr Biol. 2016 Dec 19;26(24):3361-3367
pubmed: 27889260
Curr Med Chem. 2019;26(15):2634-2660
pubmed: 29737249
Biochem Soc Trans. 2020 Oct 30;48(5):2229-2240
pubmed: 33125485
Nat Commun. 2020 Jul 17;11(1):3583
pubmed: 32681005
PLoS Biol. 2013;11(2):e1001492
pubmed: 23468591
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3536-41
pubmed: 9108011
Nature. 1995 Aug 31;376(6543):745-53
pubmed: 7651533
Biochim Biophys Acta Mol Cell Res. 2023 Jan;1870(1):119366
pubmed: 36191737
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9
pubmed: 18424797
Nat Commun. 2019 Aug 2;10(1):3489
pubmed: 31375679
Front Cell Dev Biol. 2018 Mar 22;6:30
pubmed: 29623276
J Cell Biol. 2010 Mar 22;188(6):809-20
pubmed: 20231380
Intrinsically Disord Proteins. 2013 Apr 1;1(1):e24684
pubmed: 28516010
Mol Cell. 2018 Jan 4;69(1):136-145.e6
pubmed: 29290611
Nat Rev Mol Cell Biol. 2011 Jun 02;12(7):427-38
pubmed: 21633387
Elife. 2021 Aug 03;10:
pubmed: 34342579
Elife. 2022 Aug 04;11:
pubmed: 35924897
Nucleic Acids Res. 2004 Feb 11;32(3):1037-49
pubmed: 14960716
Eur J Biochem. 1992 Apr 1;205(1):241-8
pubmed: 1313364
J Biol Chem. 2003 May 23;278(21):18817-23
pubmed: 12657641
Methods Mol Biol. 2007;365:23-38
pubmed: 17200551
Cell. 2009 Oct 30;139(3):468-84
pubmed: 19879837
Sci Signal. 2018 May 15;11(530):
pubmed: 29764992
Nat Commun. 2023 Mar 31;14(1):1798
pubmed: 37002212
Oncogene. 2022 Jan;41(1):1-14
pubmed: 34686773
Elife. 2020 Mar 20;9:
pubmed: 32195664
Biochemistry. 1998 Apr 21;37(16):5566-75
pubmed: 9548941
Nucleic Acids Res. 2022 Jan 7;50(D1):D497-D508
pubmed: 34718738
Nature. 2004 Jun 17;429(6993):780-4
pubmed: 15164081
J Cell Sci. 2022 Oct 1;135(19):
pubmed: 36205606
Biochem Biophys Res Commun. 1976 Jun 21;70(4):1308-15
pubmed: 182166
Nature. 1995 Dec 7;378(6557):641-4
pubmed: 8524402
J Biol Chem. 1982 Aug 10;257(15):8565-8
pubmed: 6284735
FEBS J. 2022 Jun;289(11):3072-3085
pubmed: 34028981
Science. 2010 Dec 17;330(6011):1673-7
pubmed: 21164014
Nat Struct Mol Biol. 2010 Apr;17(4):459-64
pubmed: 20305656
EMBO J. 1997 Apr 15;16(8):1876-87
pubmed: 9155014
Sci Signal. 2020 Sep 08;13(648):
pubmed: 32900880
Biochim Biophys Acta. 1991 Sep 3;1094(2):211-6
pubmed: 1654119
Nature. 2023 Jan;613(7945):759-766
pubmed: 36631611
Eur J Biochem. 1994 Jan 15;219(1-2):109-17
pubmed: 7508382
Sci Signal. 2017 Apr 11;10(474):
pubmed: 28400531
Sci Signal. 2008 Sep 02;1(35):ra2
pubmed: 18765831
Biochim Biophys Acta. 1988 Feb 22;968(2):179-85
pubmed: 2829978
J Biol Chem. 2007 Sep 28;282(39):28874-28883
pubmed: 17636256
Structure. 2002 May;10(5):715-24
pubmed: 12015153
J Cell Biol. 2016 Aug 29;214(5):539-54
pubmed: 27551054
Trends Biochem Sci. 2018 May;43(5):380-394
pubmed: 29544874
Essays Biochem. 2020 Sep 4;64(2):325-336
pubmed: 32501472
Elife. 2020 Dec 23;9:
pubmed: 33355089
Eur J Biochem. 1990 Apr 30;189(2):235-41
pubmed: 2159874
Science. 1997 Dec 12;278(5345):1957-60
pubmed: 9395400
Nat Commun. 2015 Dec 17;6:10215
pubmed: 26674376
Nat Cell Biol. 2017 Dec;19(12):1433-1440
pubmed: 29084198
Nat Cell Biol. 2014 Dec;16(12):1257-64
pubmed: 25402682
Life (Basel). 2021 Sep 13;11(9):
pubmed: 34575106
J Biol Chem. 1999 Mar 19;274(12):7870-8
pubmed: 10075680
J Mol Biol. 2007 Jun 22;369(5):1296-306
pubmed: 17498738
EMBO J. 2020 Jul 1;39(13):e103695
pubmed: 32400009