Identification of four novel loci associated with psychotropic drug-induced weight gain in a Swiss psychiatric longitudinal study: A GWAS analysis.

Humans Genome-Wide Association Study Antipsychotic Agents / adverse effects Longitudinal Studies Switzerland Psychotropic Drugs / adverse effects Weight Gain / genetics beta-Defensins / genetics

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
06 2023
Historique:
received: 20 04 2022
accepted: 18 04 2023
revised: 17 04 2023
medline: 30 10 2023
pubmed: 13 5 2023
entrez: 12 5 2023
Statut: ppublish

Résumé

Patients suffering from mental disorders are at high risk of developing cardiovascular diseases, leading to a reduction in life expectancy. Genetic variants can display greater influence on cardiometabolic features in psychiatric cohorts compared to the general population. The difference is possibly due to an intricate interaction between the mental disorder or the medications used to treat it and metabolic regulations. Previous genome wide association studies (GWAS) on antipsychotic-induced weight gain included a low number of participants and/or were restricted to patients taking one specific antipsychotic. We conducted a GWAS of the evolution of body mass index (BMI) during early (i.e., ≤ 6) months of treatment with psychotropic medications inducing metabolic disturbances (i.e., antipsychotics, mood stabilizers and some antidepressants) in 1135 patients from the PsyMetab cohort. Six highly correlated BMI phenotypes (i.e., BMI change and BMI slope after distinct durations of psychotropic treatment) were considered in the analyses. Our results showed that four novel loci were associated with altered BMI upon treatment at genome-wide significance (p < 5 × 10

Identifiants

DOI: 10.1038/s41380-023-02082-3 PMID: 37173452 PMC: PMC10611564
pubmed: 37173452
doi: 10.1038/s41380-023-02082-3
pii: 10.1038/s41380-023-02082-3
pmc: PMC10611564
doi:

Substances chimiques

Antipsychotic Agents 0
Psychotropic Drugs 0
DEFB1 protein, human 0
beta-Defensins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2320-2327

Informations de copyright

© 2023. The Author(s).

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Auteurs

Jennifer Sjaarda (J)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland. jennysjaarda@gmail.com.
Swiss Institute of Bioinformatics, Lausanne, Switzerland. jennysjaarda@gmail.com.

Aurélie Delacrétaz (A)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
Les Toises Psychiatry and Psychotherapy Center, Lausanne, Switzerland.

Céline Dubath (C)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
ORCID: 0000-0002-6585-8492

Nermine Laaboub (N)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Marianna Piras (M)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Claire Grosu (C)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Frederik Vandenberghe (F)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Séverine Crettol (S)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
ORCID: 0000-0003-3790-7194

Nicolas Ansermot (N)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Franziska Gamma (F)

Les Toises Psychiatry and Psychotherapy Center, Lausanne, Switzerland.

Kerstin Jessica Plessen (KJ)

Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.

Armin von Gunten (A)

Service of Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
ORCID: 0000-0001-7852-3803

Philippe Conus (P)

Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

Zoltan Kutalik (Z)

Swiss Institute of Bioinformatics, Lausanne, Switzerland.
University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0001-8285-7523

Chin B Eap (CB)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland. chin.eap@chuv.ch.
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. chin.eap@chuv.ch.
Center for Research and Innovation in Clinical Pharmaceutical Sciences, University of Lausanne, Lausanne, Switzerland. chin.eap@chuv.ch.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva, Switzerland. chin.eap@chuv.ch.
ORCID: 0000-0002-5439-0230

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