Oral Microbiome Community Composition in Head and Neck Squamous Cell Carcinoma.
head and neck cancer
head and neck squamous cell carcinoma
microbiome community type
oral microbiome
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Apr 2023
29 Apr 2023
Historique:
received:
10
02
2023
revised:
13
03
2023
accepted:
27
04
2023
medline:
13
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
The impact of the oral microbiome on head and neck cancer pathogenesis and outcomes requires further study. 16s rRNA was isolated and amplified from pre-treatment oral wash samples for 52 cases and 102 controls. The sequences were binned into operational taxonomic units (OTUs) at the genus level. Diversity metrics and significant associations between OTUs and case status were assessed. The samples were binned into community types using Dirichlet multinomial models, and survival outcomes were assessed by community type. Twelve OTUs from the phyla Firmicutes, Proteobacteria, and Acinetobacter were found to differ significantly between the cases and the controls. Beta-diversity was significantly higher between the cases than between the controls (
Identifiants
pubmed: 37174014
pii: cancers15092549
doi: 10.3390/cancers15092549
pmc: PMC10177240
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : R01 CA250215
Pays : United States
Organisme : NIH HHS
ID : P01 CA240239
Pays : United States
Organisme : NIH HHS
ID : P30 RS017885
Pays : United States
Organisme : NIH HHS
ID : K08 17-OA507511
Pays : United States
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