Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization.
Suzuki–Miyaura cross coupling
catalysis
cyclopropylthiophene
thiophene
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Apr 2023
27 Apr 2023
Historique:
received:
20
04
2023
revised:
26
04
2023
accepted:
26
04
2023
medline:
13
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties.
Identifiants
pubmed: 37175178
pii: molecules28093770
doi: 10.3390/molecules28093770
pmc: PMC10180236
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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