The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease.
fibrosis
fucoxanthin
lipid
liver
non-alcoholic
obesity
thermogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 May 2023
03 May 2023
Historique:
received:
20
03
2023
revised:
27
04
2023
accepted:
01
05
2023
medline:
15
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
Chronic liver disease (CLD) has emerged as a leading cause of human deaths. It caused 1.32 million deaths in 2017, which affected men more than women by a two-to-one ratio. There are various causes of CLD, including obesity, excessive alcohol consumption, and viral infection. Among them, non-alcoholic fatty liver disease (NAFLD), one of obesity-induced liver diseases, is the major cause, representing the cause of more than 50% of cases. Fucoxanthin, a carotenoid mainly found in brown seaweed, exhibits various biological activities against NAFLD. Its role in NAFLD appears in several mechanisms, such as inducing thermogenesis in mitochondrial homeostasis, altering lipid metabolism, and promoting anti-inflammatory and anti-oxidant activities. The corresponding altered signaling pathways are the β3-adorenarine receptor (β3Ad), proliferator-activated receptor gamma coactivator (PGC-1), adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), sterol regulatory element binding protein (SREBP), nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), SMAD2/3, and P13K/Akt pathways. Fucoxanthin also exhibits anti-fibrogenic activity that prevents non-alcoholic steatohepatitis (NASH) development.
Identifiants
pubmed: 37175909
pii: ijms24098203
doi: 10.3390/ijms24098203
pmc: PMC10179653
pii:
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
fucoxanthin
06O0TC0VSM
Xanthophylls
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Trade, Industry and Energy
ID : 20020268
Organisme : Ministry of Oceans and Fisheries
ID : 20220134
Organisme : Ministry of Oceans and Fisheries
ID : 20220027
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