In Vitro and In Vivo Therapeutic Potential of 6,6'-Dihydroxythiobinupharidine (DTBN) from

6,6′-dihydroxythiobinupharidine (DTBN) COVID-19 RNA-dependent RNA polymerase (RdRp) SARS-CoV-2 anti-viral small molecule drug

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 May 2023
Historique:
received: 21 03 2023
revised: 27 04 2023
accepted: 02 05 2023
medline: 15 5 2023
pubmed: 13 5 2023
entrez: 13 5 2023
Statut: epublish

Résumé

We have previously published research on the anti-viral properties of an alkaloid mixture extracted from

Identifiants

pubmed: 37176034
pii: ijms24098327
doi: 10.3390/ijms24098327
pmc: PMC10179516
pii:
doi:

Substances chimiques

dihydroxythiobinupharidine 30343-70-5
K-18 conjugate 0
Alkaloids 0
Plant Extracts 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Israel Ministry of Health
ID : 3-0-7374

Références

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Auteurs

Shay Weiss (S)

Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.

Kamran Waidha (K)

The Shraga Segal Department of Microbiology, Immunology & Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.

Saravanakumar Rajendran (S)

Chemistry Division, SAS, Vellore Institute of Technology, Chennai Campus, Chennai 600127, India.

Daniel Benharroch (D)

Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.

Jannat Khalilia (J)

The Shraga Segal Department of Microbiology, Immunology & Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.

Haim Levy (H)

Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.

Elad Bar-David (E)

Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.

Avi Golan-Goldhirsh (A)

The Jacob Blaustein Institutes for Desert Research (BIDR), Ben-Gurion University of the Negev, Sede Boqer Campus, Sde Boker 8410501, Israel.

Jacob Gopas (J)

The Shraga Segal Department of Microbiology, Immunology & Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.

Amir Ben-Shmuel (A)

Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.

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Classifications MeSH