Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes.

Mice Animals Nitric Oxide Synthase Type III / metabolism Vasodilation Sphingomyelin Phosphodiesterase / metabolism NG-Nitroarginine Methyl Ester / pharmacology Diabetes Mellitus, Type 2 / metabolism Nitric Oxide / metabolism Disease Models, Animal Endothelium, Vascular / metabolism Enzyme Inhibitors / pharmacology
endothelial nitric oxide synthase sphingolipids sphingomyelinase thromboxane prostanoid receptor type 2 diabetes vasorelaxation

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 May 2023
Historique:
received: 28 02 2023
revised: 30 04 2023
accepted: 04 05 2023
medline: 15 5 2023
pubmed: 13 5 2023
entrez: 13 5 2023
Statut: epublish

Résumé

Sphingolipids are important biological mediators both in health and disease. We investigated the vascular effects of enhanced sphingomyelinase (SMase) activity in a mouse model of type 2 diabetes mellitus (T2DM) to gain an understanding of the signaling pathways involved. Myography was used to measure changes in the tone of the thoracic aorta after administration of 0.2 U/mL neutral SMase in the presence or absence of the thromboxane prostanoid (TP) receptor antagonist SQ 29,548 and the nitric oxide synthase (NOS) inhibitor L-NAME. In precontracted aortic segments of non-diabetic mice, SMase induced transient contraction and subsequent weak relaxation, whereas vessels of diabetic (

Identifiants

DOI: 10.3390/ijms24098375 PMID: 37176081 PMC: PMC10179569
pubmed: 37176081
pii: ijms24098375
doi: 10.3390/ijms24098375
pmc: PMC10179569
pii:
doi:

Substances chimiques

Nitric Oxide Synthase Type III EC 1.14.13.39
Sphingomyelin Phosphodiesterase EC 3.1.4.12
NG-Nitroarginine Methyl Ester V55S2QJN2X
Nitric Oxide 31C4KY9ESH
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hungarian National Research, Development, and Innovation Office
ID : K-112964
Organisme : Hungarian National Research, Development, and Innovation Office
ID : K-125174
Organisme : Hungarian National Research, Development, and Innovation Office
ID : K-139230
Organisme : Hungarian National Research, Development, and Innovation Office
ID : PD-132851
Organisme : Ministry of Innovation and Technology of Hungary from the NRDI Fund
ID : 2020-1.1.6-JÖVŐ-2021-00010
Organisme : Ministry of Innovation and Technology of Hungary from the NRDI Fund
ID : 2020-1.1.6-JÖVŐ-2021-00013
Organisme : Ministry of Innovation and Technology of Hungary from the NRDI Fund
ID : TKP2021-EGA-25

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Auteurs

Éva Ruisanchez (É)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.
Eötvös Loránd Research Network and Semmelweis University (ELKH-SE) Cerebrovascular and Neurocognitive Disorders Research Group, H-1052 Budapest, Hungary.
ORCID: 0000-0001-7779-226X

Anna Janovicz (A)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.
Eötvös Loránd Research Network and Semmelweis University (ELKH-SE) Cerebrovascular and Neurocognitive Disorders Research Group, H-1052 Budapest, Hungary.

Rita Cecília Panta (RC)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.

Levente Kiss (L)

Department of Physiology, Semmelweis University, H-1094 Budapest, Hungary.
ORCID: 0000-0003-1514-9978

Adrienn Párkányi (A)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.

Zsuzsa Straky (Z)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.

Dávid Korda (D)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.

Károly Liliom (K)

Institute of Biophysics and Radiation Biology, Semmelweis University, H-1094 Budapest, Hungary.
ORCID: 0000-0002-7177-6872

Gábor Tigyi (G)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
ORCID: 0000-0001-5371-171X

Zoltán Benyó (Z)

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.
Eötvös Loránd Research Network and Semmelweis University (ELKH-SE) Cerebrovascular and Neurocognitive Disorders Research Group, H-1052 Budapest, Hungary.
ORCID: 0000-0001-6015-0359

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Nitric oxide synthase type III › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphodiesterases › Sphingomyeline phosphodiesterase › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés diaminés › L-NAME › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Enhancement of Sphingomyelinase-Induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Enhancement of Sphingomyelinase-Induced...