Impact of Single Hemodialysis Treatment on immune Cell Subpopulations.
Annexin V
B cells
IFN-gamma
Th1
Th17
Th2
hemodialysis
immune response
inflammation
lymphocytes
natural killer cells
proliferation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
25 Apr 2023
25 Apr 2023
Historique:
received:
08
03
2023
revised:
13
04
2023
accepted:
17
04
2023
medline:
13
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
Hemodialysis (HD) is known to trigger a chronic inflammatory status, affecting the innate and acquired immune response. This study was aimed at a comparative analysis of immune cell subsets, proliferation, and apoptosis in subjects receiving chronic HD treatment with respect to a healthy control. Regardless of the dialysis filter used, we observed a reshaping of the acquired immune component both with respect to healthy patients and between the various sessions of dialysis treatment, with an impairment of CD3 cells, along with an increase in CD4 and CD8 cell populations producing pro-inflammatory factors such as IL-17 and IFN-gamma. The population of B cells, monocytes and NK cells were not impaired by the dialysis procedure. These results confirmed the high impact of the HD treatment on the patient's immune system, underlying the imbalance of T cell counterparts.
Identifiants
pubmed: 37176548
pii: jcm12093107
doi: 10.3390/jcm12093107
pmc: PMC10179690
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Kidney Int. 2011 Jul;80(2):208-17
pubmed: 21525849
Immunol Rev. 2014 May;259(1):115-39
pubmed: 24712463
J Am Soc Nephrol. 2014 Sep;25(9):2003-15
pubmed: 24676641
Am J Nephrol. 2010;31(3):247-54
pubmed: 20090311
Biochem Biophys Res Commun. 2003 Aug 29;308(3):581-5
pubmed: 12914790
Int Immunol. 2015 Nov;27(11):579-88
pubmed: 25995267
Immunity. 2013 Dec 12;39(6):1143-57
pubmed: 24315997
Kidney Int. 2010 Jun;77(12):1070-5
pubmed: 20375986
Semin Vasc Surg. 2021 Mar;34(1):71-78
pubmed: 33757639
Front Immunol. 2018 Jan 25;9:71
pubmed: 29422906
Mol Immunol. 2007 Jan;44(1-3):82-94
pubmed: 16905192
Nephrol Dial Transplant. 2010 Mar;25(3):737-46
pubmed: 19903659
Annu Rev Immunol. 1998;16:359-93
pubmed: 9597134
Minerva Urol Nefrol. 2010 Mar;62(1):51-66
pubmed: 20424570
Blood Purif. 2008;26(3):291-9
pubmed: 18421214
Int J Endocrinol. 2013;2013:569831
pubmed: 23737775
J Clin Immunol. 2012 Feb;32(1):189-200
pubmed: 21993694
Ren Fail. 2016;38(1):7-14
pubmed: 26539739
Artif Organs. 2021 Jul;45(7):770-778
pubmed: 33326619
Kidney Int. 1993 Sep;44(3):484-94
pubmed: 8231020
Artif Organs. 2010 Mar;34(3):E77-84
pubmed: 20447038
Vaccine. 2004 Sep 28;22(29-30):3963-7
pubmed: 15364445
Hum Immunol. 2022 Feb;83(2):134-143
pubmed: 34802797
J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S274-80
pubmed: 17130274
Medicina (Kaunas). 2020 Feb 12;56(2):
pubmed: 32059426
Front Med (Lausanne). 2021 Sep 09;8:742419
pubmed: 34568395
Cell Mol Immunol. 2006 Apr;3(2):151-4
pubmed: 16696903
Front Immunol. 2020 Mar 05;11:310
pubmed: 32194559
Perit Dial Int. 2008 Jun;28 Suppl 3:S183-7
pubmed: 18552253