The relationship between mental health, sleep quality and the immunogenicity of COVID-19 vaccinations.
COVID-19 vaccination
immune response
psychiatric disorders
sleep function
sleep regulation
system consolidation
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
13 May 2023
13 May 2023
Historique:
revised:
25
04
2023
received:
02
03
2023
accepted:
26
04
2023
medline:
13
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
aheadofprint
Résumé
Sleep modulates the immune response, and sleep loss can reduce vaccine immunogenicity; vice versa, immune responses impact sleep. We aimed to investigate the influence of mental health and sleep quality on the immunogenicity of COVID-19 vaccinations and, conversely, of COVID-19 vaccinations on sleep quality. The prospective CoVacSer study monitored mental health, sleep quality and Anti-SARS-CoV-2-Spike IgG titres in a cohort of 1082 healthcare workers from 29 September 2021 to 19 December 2022. Questionnaires and blood samples were collected before, 14 days, and 3 months after the third COVID-19 vaccination, as well as in 154 participants before and 14 days after the fourth COVID-19 vaccination. Healthcare workers with psychiatric disorders had slightly lower Anti-SARS-CoV-2-Spike IgG levels before the third COVID-19 vaccination. However, this effect was mediated by higher median age and body mass index in this subgroup. Antibody titres following the third and fourth COVID-19 vaccinations ("booster vaccinations") were not significantly different between subgroups with and without psychiatric disorders. Sleep quality did not affect the humoral immunogenicity of the COVID-19 vaccinations. Moreover, the COVID-19 vaccinations did not impact self-reported sleep quality. Our data suggest that in a working population neither mental health nor sleep quality relevantly impact the immunogenicity of COVID-19 vaccinations, and that COVID-19 vaccinations do not cause a sustained deterioration of sleep, suggesting that they are not a precipitating factor for insomnia. The findings from this large-scale real-life cohort study will inform clinical practice regarding the recommendation of COVID-19 booster vaccinations for individuals with mental health and sleep problems.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13929Subventions
Organisme : Wellcome Trust
ID : 203971/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
Références
Anderson, C., Sullivan, J. P., Flynn-Evans, E. E., Cade, B. E., Czeisler, C. A., & Lockley, S. W. (2012). Deterioration of neurobehavioral performance in resident physicians during repeated exposure to extended duration work shifts. Sleep, 35(8), 1137-1146. https://doi.org/10.5665/sleep.2004
Athanasiou, N., Baou, K., Papandreou, E., Varsou, G., Amfilochiou, A., Kontou, E., Pataka, A., Porpodis, K., Tsiouprou, I., Kaimakamis, E., Kotoulas, S.-C., Katsibourlia, E., Alexopoulou, C., Bouloukaki, I., Panagiotarakou, M., Dermitzaki, A., Charokopos, N., Pagdatoglou, K., Lamprou, K., … Vagiakis, E. (2023). Association of sleep duration and quality with immunological response after vaccination against severe acute respiratory syndrome coronavirus-2 infection. Journal of Sleep Research, 32(1), e13656. https://doi.org/10.1111/jsr.13656
Avila, C., Holloway, A. C., Hahn, M. K., Morrison, K. M., Restivo, M., Anglin, R., & Taylor, V. H. (2015). An overview of links between obesity and mental health. Current Obesity Reports, 4, 303-310. https://doi.org/10.1007/s13679-015-0164-9
Ayling, K., Fairclough, L., Tighe, P., Todd, I., Halliday, V., Garibaldi, J., Royal, S., Hamed, A., Buchanan, H., & Vedhara, K. (2018). Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study. Brain, Behavior, and Immunity, 67, 314-323. https://doi.org/10.1016/j.bbi.2017.09.008
Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., McGettigan, J., Khetan, S., Segall, N., Solis, J., Brosz, A., Fierro, C., Schwartz, H., Neuzil, K., Corey, L., … Zaks, T. (2020). Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. New England Journal of Medicine, 384(5), 403-416. https://doi.org/10.1056/NEJMoa2035389
Baglioni, C., Regen, W., Teghen, A., Spiegelhalder, K., Feige, B., Nissen, C., & Riemann, D. (2014). Sleep changes in the disorder of insomnia: A meta-analysis of polysomnographic studies. Sleep Medicine Reviews, 18, 195-213. https://doi.org/10.1016/j.smrv.2013.04.001
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit. (2023). Übersicht der Fallzahlen von Coronavirusinfektionen in Bayern. https://www.lgl.bayern.de/gesundheit/infektionsschutz/infektionskrankheiten_a_z/coronavirus/karte_coronavirus/ (Accessed 26 February 2023)
Benedict, C., Brytting, M., Markström, A., Broman, J.-E., & Schiöth, H. B. (2012). Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza a H1N1 virus vaccination. BMC Immunology, 13(1), 1. https://doi.org/10.1186/1471-2172-13-1
Benenson, S., Oster, Y., Cohen, M. J., & Nir-Paz, R. (2021). BNT162b2 mRNA Covid-19 vaccine effectiveness among health care workers. New England Journal of Medicine, 384(18), 1775-1777. https://doi.org/10.1056/NEJMc2101951
Benz, F., Riemann, D., Domschke, K., Spiegelhalder, K., Johann, A. F., Marshall, N. S., & Feige, B. (2022). How many hours do you sleep? A comparison of subjective and objective sleep duration measures in a sample of insomnia patients and good sleepers. Journal of Sleep Research, 32(2), e13802. https://doi.org/10.1111/jsr.13802
Besedovsky, L., Lange, T., & Haack, M. (2019). The sleep-immune crosstalk in health and disease. Physiological Reviews, 99, 1325-1380. https://doi.org/10.1152/physrev.00010.2018
Buysse, D. J., Reynolds, C. F., 3rd, Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193-213. https://doi.org/10.1016/0165-1781(89)90047-4
Chang, Y.-S., Chen, H.-L., Hsu, C.-Y., Su, S.-F., Liu, C.-K., & Hsu, C. (2013). Nurses working on fast rotating shifts overestimate cognitive function and the capacity of maintaining wakefulness during the daytime after a rotating shift. Sleep Medicine, 14(7), 605-613. https://doi.org/10.1016/j.sleep.2013.03.011
Dopp, J. M., Wiegert, N. A., Moran, J. J., Muller, D., Weber, S., & Hayney, M. S. (2007). Humoral immune responses to influenza vaccination in patients with obstructive sleep apnea. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 27(11), 1483-1489. https://doi.org/10.1592/phco.27.11.1483
European Medicines Agency (EMA). (2023). Authorised COVID-19 vaccines. https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/vaccines-covid-19/covid-19-vaccines-authorised#authorised-covid-19-vaccines-section (Accessed 26 February 2023)
Gesundheitsberichterstattung des Bundes. (2021). Gesundheitspersonal in 1.000. Gliederungsmerkmale: Jahre, Deutschland, Alter, Beschäftigungsart, Beruf. https://www.gbe-bund.de/gbe/!pkg_olap_tables.prc_set_orientation?p_uid=gast&p_aid=25632989&p_sprache=D&p_help=2&p_indnr=96&p_ansnr=82673282&p_version=2&D.000=1&D.002=1&D.767=1&D.489=2 (Accessed 26 February 2023)
Gholami, A., Jahromi, L. M., Zarei, E., & Dehghan, A. (2013). Application of WHOQOL-BREF in measuring quality of life in health-care staff. International Journal of Preventive Medicine, 4(7), 809-817.
Gross, J. V., Mohren, J., & Erren, T. C. (2021). COVID-19 and healthcare workers: A rapid systematic review into risks and preventive measures. BMJ Open, 11(1), e042270. https://doi.org/10.1136/bmjopen-2020-042270
Harris, P. A., Taylor, R., Minor, B. L., Elliott, V., Fernandez, M., O'Neal, L., McLeod, L., Delacqua, G., Delacqua, F., Kirby, J., & Duda, S. N. (2019). The REDCap consortium: Building an international community of software platform partners. Journal of Biomedical Informatics, 95, 103208. https://doi.org/10.1016/j.jbi.2019.103208
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009). Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics, 42(2), 377-381. https://doi.org/10.1016/j.jbi.2008.08.010
Kow, C. S., & Hasan, S. S. (2021). Do sleep quality and sleep duration before or after COVID-19 vaccination affect antibody response? Chronobiology International, 38(7), 941-943. https://doi.org/10.1080/07420528.2021.1900216
Krone, M., Gütling, J., Wagener, J., Lâm, T.-T., Schoen, C., Vogel, U., Stich, A., Wedekink, F., Wischhusen, J., Kerkau, T., Beyersdorf, N., Klingler, S., Backes, S., Dölken, L., Gasteiger, G., Kurzai, O., & Schubert-Unkmeir, A. (2021). Performance of three SARS-CoV-2 immunoassays, three rapid lateral flow tests, and a novel bead-based affinity surrogate test for the detection of SARS-CoV-2 antibodies in human serum. Journal of Clinical Microbiology, 59(8), e00319-e00321. https://doi.org/10.1128/JCM.00319-21
Lammers-van der Holst, H. M., Lammers, G. J., van der Horst, G. T. J., Chaves, I., de Vries, R. D., GeurtsvanKessel, C. H., Koch, B., & van der Kuy, H. M. (2022). Understanding the association between sleep, shift work and COVID-19 vaccine immune response efficacy: Protocol of the S-CORE study. Journal of Sleep Research, 31(2), e13496. https://doi.org/10.1111/jsr.13496
Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S., & Born, J. (2011). Sleep after vaccination boosts immunological memory. The Journal of Immunology, 187(1), 283-290. https://doi.org/10.4049/jimmunol.1100015
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003). Sleep enhances the human antibody response to hepatitis a vaccination. Psychosomatic Medicine, 65(5), 831-835. https://doi.org/10.1097/01.psy.0000091382.61178.f1
Mazereel, V., Van Assche, K., Detraux, J., & De Hert, M. (2021). COVID-19 vaccination for people with severe mental illness: Why, what, and how? The Lancet Psychiatry, 8(5), 444-450. https://doi.org/10.1016/S2215-0366(20)30564-2
Montgomery, C. M., Humphreys, S., McCulloch, C., Docherty, A. B., Sturdy, S., & Pattison, N. (2021). Critical care work during COVID-19: A qualitative study of staff experiences in the UK. BMJ Open, 11(5), e048124. https://doi.org/10.1136/bmjopen-2020-048124
Morin, C. M., Vézina-Im, L.-A., Ivers, H., Micoulaud-Franchi, J.-A., Philip, P., Lamy, M., & Savard, J. (2021). Prevalent, incident, and persistent insomnia in a population-based cohort tested before (2018) and during the first-wave of COVID-19 pandemic (2020). Sleep, 45(1), zsab258. https://doi.org/10.1093/sleep/zsab258
Perkmann, T., Perkmann-Nagele, N., Koller, T., Mucher, P., Radakovics, A., Marculescu, R., Wolzt, M., Wagner, O. F., Binder, C. J., Haslacher, H., & Powell, E. A. (2021). Anti-spike protein assays to determine SARS-CoV-2 antibody levels: A head-to-head comparison of five quantitative assays. Microbiology Spectrum, 9(1), e0024721. https://doi.org/10.1128/Spectrum.00247-21
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., Bailey, R., Swanson, K. A., Roychoudhury, S., Koury, K., Li, P., Kalina, W. V., Cooper, D., Frenck, R. W., Hammitt, L. L., … Gruber, W. C. (2020). Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New England Journal of Medicine, 383(27), 2603-2615. https://doi.org/10.1056/NEJMoa2034577
Prather, A. A., Hall, M., Fury, J. M., Ross, D. C., Muldoon, M. F., Cohen, S., & Marsland, A. L. (2012). Sleep and antibody response to hepatitis B vaccination. Sleep, 35(8), 1063-1069. https://doi.org/10.5665/sleep.1990
Prather, A. A., Pressman, S. D., Miller, G. E., & Cohen, S. (2021). Temporal links between self-reported sleep and antibody responses to the influenza vaccine. International Journal of Behavioral Medicine, 28(1), 151-158. https://doi.org/10.1007/s12529-020-09879-4
Rayatdoost, E., Rahmanian, M., Sanie, M. S., Rahmanian, J., Matin, S., Kalani, N., Kenarkoohi, A., Falahi, S., & Abdoli, A. (2022). Sufficient sleep, time of vaccination, and vaccine efficacy: A systematic review of the current evidence and a proposal for COVID-19 vaccination. The Yale Journal of Biology and Medicine, 95(2), 221-235.
Reusch, J., Wagenhäuser, I., Gabel, A., Eggestein, A., Höhn, A., Lâm, T. T., Frey, A., Schubert-Unkmeir, A., Dölken, L., Frantz, S., Kurzai, O., Vogel, U., Krone, M., & Petri, N. (2023). Influencing factors of anti-SARS-CoV-2-spike-IgG antibody titers in healthcare workers: A cross-section study. Journal of Medical Virology, 95(1), e28300. https://doi.org/10.1002/jmv.28300
Riemann, D., Krone, L. B., Wulff, K., & Nissen, C. (2020). Sleep, insomnia, and depression. Neuropsychopharmacology, 45(1), 74-89. https://doi.org/10.1038/s41386-019-0411-y
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010). The hyperarousal model of insomnia: A review of the concept and its evidence. Sleep Medicine Reviews, 14(1), 19-31. https://doi.org/10.1016/j.smrv.2009.04.002
Robert Koch-Institut (RKI). (2021). Epidemiologisches Bulletin: 14. Aktualisierung der COVID-19-Impfempfehlung. https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2021/Ausgaben/48_21.pdf?__blob=publicationFile (Accessed 26 February 2023)
Sharpley, A. L., Cooper, C. M., Williams, C., Godlewska, B. R., & Cowen, P. J. (2016). Effects of typhoid vaccine on inflammation and sleep in healthy participants: A double-blind, placebo-controlled, crossover study. Psychopharmacology, 233, 3429-3435. https://doi.org/10.1007/s00213-016-4381-z
Skevington, S. M. (1999). Measuring quality of life in britain: Introducing the WHOQOL-100. Journal of Psychosomatic Research, 47(5), 449-459. https://doi.org/10.1016/s0022-3999(99)00051-3
Soldatos, C. R., Dikeos, D. G., & Paparrigopoulos, T. J. (2000). Athens insomnia scale: Validation of an instrument based on ICD-10 criteria. Journal of Psychosomatic Research, 48(6), 555-560. https://doi.org/10.1016/s0022-3999(00)00095-7
Spiegel, K., Sheridan, J. F., & Van Cauter, E. (2002). Effect of sleep deprivation on response to immunization. Jama, 288(12), 1471-1472. https://doi.org/10.1001/jama.288.12.1471-a
Taylor, D. J., Kelly, K., Kohut, M. L., & Song, K.-S. (2017). Is insomnia a risk factor for decreased influenza vaccine response? Behavioral Sleep Medicine, 15(4), 270-287. https://doi.org/10.1080/15402002.2015.1126596
van den Berg, T. I. J., Elders, L. A. M., de Zwart, B. C. H., & Burdorf, A. (2009). The effects of work-related and individual factors on the work ability index: A systematic review. Occupational and Environmental Medicine, 66(4), 211-220. https://doi.org/10.1136/oem.2008.039883
Wolkow, A., Ferguson, S., Aisbett, B., & Main, L. (2015). Effects of work-related sleep restriction on acute physiological and psychological stress responses and their interactions: A review among emergency service personnel. International Journal of Occupational Medicine and Environmental Health, 28(2), 183-208. https://doi.org/10.13075/ijomeh.1896.00227
Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., Yuan, M.-L., Zhang, Y.-L., Dai, F.-H., Liu, Y., Wang, Q.-M., Zheng, J.-J., Xu, L., Holmes, E. C., & Zhang, Y.-Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798), 265-269. https://doi.org/10.1038/s41586-020-2008-3
Xiao, K., Gillissie, E. S., Lui, L. M. W., Ceban, F., Teopiz, K. M., Gill, H., Cao, B., Ho, R., Rosenblat, J. D., & McIntyre, R. S. (2022). Immune response to vaccination in adults with mental disorders: A systematic review. Journal of Affective Disorders, 304, 66-77. https://doi.org/10.1016/j.jad.2022.02.025
Zhu, J., Zhang, M., Sanford, L. D., & Tang, X. (2021). Advice for COVID-19 vaccination: Get some sleep. Sleep and Breathing, 25(4), 2287-2288. https://doi.org/10.1007/s11325-021-02313-3
Zimmermann, P., & Curtis, N. (2019). Factors that influence the immune response to vaccination. Clinical Microbiology Reviews, 32(2), e0008418. https://doi.org/10.1128/CMR.00084-18