Curating evidence for a cure of HIV-1 infection by hematopoietic stem cell transplantation.

Humans HIV-1 / genetics HIV Infections / therapy HIV Seropositivity Hematopoietic Stem Cell Transplantation / methods Hematologic Neoplasms

Journal

Med (New York, N.Y.)
ISSN: 2666-6340
Titre abrégé: Med
Pays: United States
ID NLM: 101769215

Informations de publication

Date de publication:
12 05 2023
Historique:
received: 14 04 2023
revised: 17 04 2023
accepted: 18 04 2023
medline: 15 5 2023
pubmed: 14 5 2023
entrez: 13 5 2023
Statut: ppublish

Résumé

A cure of HIV-1 infection has previously been described in two individuals undergoing allogeneic hematopoietic stem cell transplants from homozygous carriers of the CCR5Δ32 gene variant, which confers HIV-1 resistance. Two recent reports corroborate these earlier studies, underscoring that in HIV-1-infected persons with hematologic malignancies, these procedures may provide a realistic perspective for a cure of HIV-1 infection.

Identifiants

DOI: 10.1016/j.medj.2023.04.006 PMID: 37178680
pubmed: 37178680
pii: S2666-6340(23)00138-1
doi: 10.1016/j.medj.2023.04.006
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

285-287

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI164560
Pays : United States

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interest The authors declare no competing interests.

Auteurs

Benjamin Bone (B)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: bbone@mgh.harvard.edu.

Mathias Lichterfeld (M)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: mlichterfeld@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Curating evidence for a cure of HIV-1...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Curating evidence for a cure of HIV-1...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Curating evidence for a cure of HIV-1...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Séropositivité VIH › Curating evidence for a cure of HIV-1...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Curating evidence for a cure of HIV-1...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › Curating evidence for a cure of HIV-1...