Do different exosome biogenesis pathways and selective cargo enrichment contribute to exosomal heterogeneity?
biogenesis
cargo
exosomes
heterogeneity
miRNA
mitochondrial DNA
Journal
Biology of the cell
ISSN: 1768-322X
Titre abrégé: Biol Cell
Pays: England
ID NLM: 8108529
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
revised:
01
05
2023
received:
10
12
2022
accepted:
04
05
2023
medline:
13
7
2023
pubmed:
14
5
2023
entrez:
14
5
2023
Statut:
ppublish
Résumé
Exosomes are emerging intercellular communicators essential for cellular homeostasis during development and differentiation. The dysregulation in exosome-mediated communication alters cellular networking leads to developmental defects and chronic diseases. Exosomes are heterogeneous in nature depending on differences in size, membrane protein abundance, and differential cargo load. In this review, we have highlighted the latest developments in exosome biogenesis pathways, heterogeneity, and selective enrichment of various exosomal cargoes including proteins, nucleic acids, and mitochondrial DNA. Furthermore, the recent developments in the isolation techniques of exosome subpopulations have also been discussed. The comprehensive knowledge of extracellular vesicle (EV) heterogeneity and selective cargo enrichment during specific pathology may provide a clue for disease severity and early prognosis possibilities. The release of specific exosome subtypes is associated with the progression of specific disease type and hence a probable tool for therapeutics and biomarker development.
Identifiants
pubmed: 37179461
doi: 10.1111/boc.202200116
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200116Informations de copyright
© 2023 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.
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