Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review.
Alzheimer’s disease
Amyloid beta
Cognitive decline
Neuroimaging
Systematic review
Journal
Aging brain
ISSN: 2589-9589
Titre abrégé: Aging Brain
Pays: Netherlands
ID NLM: 101776137
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
10
2022
revised:
21
03
2023
accepted:
11
04
2023
medline:
14
5
2023
pubmed:
14
5
2023
entrez:
14
5
2023
Statut:
epublish
Résumé
This systematic review examined the longitudinal association between amyloid-β (Aβ) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Aβ change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Aβ. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss-to follow up and missing data, and failure to report
Identifiants
pubmed: 37180874
doi: 10.1016/j.nbas.2023.100074
pii: S2589-9589(23)00011-7
pmc: PMC10173297
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100074Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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