Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer.
MiRNAome
colorectal cancer
liver metastasis
methylome
transcriptome
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
12
2022
accepted:
20
03
2023
medline:
14
5
2023
pubmed:
14
5
2023
entrez:
14
5
2023
Statut:
epublish
Résumé
Despite distant metastases being the critical factor affecting patients' survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles differ between Synchronous (SmCRC) and Metachronous (MmCRC) colorectal cancer. This characterization was performed by whole exome sequencing, whole transcriptome, whole methylome, and miRNAome. The most frequent somatic mutations were in
Identifiants
pubmed: 37182133
doi: 10.3389/fonc.2023.1133598
pmc: PMC10172672
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1133598Informations de copyright
Copyright © 2023 Horak, Kubecek, Siskova, Honkova, Chvojkova, Krupova, Manethova, Vodenkova, García-Mulero, John, Cecka, Vodickova, Petera, Filip and Vymetalkova.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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