The oxygen transport cascade and exercise: Lessons from comparative physiology.
Comparative physiology
Exercise physiology
Krogh principle
Oxygen transport cascade
Journal
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
ISSN: 1531-4332
Titre abrégé: Comp Biochem Physiol A Mol Integr Physiol
Pays: United States
ID NLM: 9806096
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
24
02
2023
revised:
09
05
2023
accepted:
11
05
2023
pmc-release:
01
08
2024
medline:
14
6
2023
pubmed:
15
5
2023
entrez:
14
5
2023
Statut:
ppublish
Résumé
Studies of animal physiology not only provide valuable knowledge for the species in question, but also offer insights into human physiology. This thought is best highlighted by the 'Krogh Principle', which states "for many problems there is an animal on which it can be most conveniently studied". This graphical review focuses on three distinct stages of the oxygen transport cascade in which human exercise physiology knowledge has been enhanced by studies carried out in animal models. We begin by exploring ventilation, and the detrimental effects of cold, dry air on the airways in two sets of elite athletes, the cross-country skier and the racing sled dog. We then discuss the transport of oxygen via hemoglobin in humans and deer mice with relatively shifted oxygen dissociation curves. Finally, we consider the technical difficulties of measuring respiratory muscle blood flow in exercising humans and how an equine model can provide an understanding of the distribution of blood flow during exercise. These cases illustrate the complementary nature of physiological studies across species.
Identifiants
pubmed: 37182787
pii: S1095-6433(23)00075-2
doi: 10.1016/j.cbpa.2023.111442
pmc: PMC10330610
mid: NIHMS1902534
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111442Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL154320
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139854
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors (Andrew H. Ramsook, Paolo B. Dominelli, Sarah A. Angus, Jonathon W. Senefeld, Chad C. Wiggins Michael J. Joyner) declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
J Exp Biol. 2005 May;208(Pt 9):1611-9
pubmed: 15855392
Sports Med. 2020 Nov;50(11):1963-1981
pubmed: 32915429
Rev Med Interne. 2017 Feb;38(2):106-112
pubmed: 27637720
J Physiol. 2020 Apr;598(8):1475-1490
pubmed: 31923331
Invest Radiol. 1969 Nov-Dec;4(6):374-86
pubmed: 4904709
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5484-8
pubmed: 6591201
Am J Physiol. 1986 Jul;251(1 Pt 2):H121-6
pubmed: 3728688
J Appl Physiol (1985). 1992 May;72(5):1810-7
pubmed: 1601790
J Appl Physiol (1985). 1985 Jan;58(1):193-9
pubmed: 3917990
BMJ Open Sport Exerc Med. 2022 May 12;8(2):e001315
pubmed: 35865073
Am J Physiol Regul Integr Comp Physiol. 2015 May 1;308(9):R779-91
pubmed: 25695288
Compr Physiol. 2011 Jan;1(1):1-37
pubmed: 23737162
Am Rev Respir Dis. 1985 May;131(5):700-8
pubmed: 3923878
Brain Res Bull. 1998 Jul 15;46(5):381-407
pubmed: 9739001
J Appl Physiol (1985). 2021 Feb 1;130(2):369-379
pubmed: 33151776
Eur Respir J. 1999 Mar;13(3):626-32
pubmed: 10232438
Respir Physiol. 1981 Apr;44(1):1-10
pubmed: 7232879
Circ Res. 1969 Jan;24(1):33-42
pubmed: 5763738
Compr Physiol. 2015 Sep 20;5(4):1677-703
pubmed: 26426464
Am J Physiol Regul Integr Comp Physiol. 2011 Apr;300(4):R984-92
pubmed: 21289237
Am J Respir Crit Care Med. 2002 Sep 15;166(6):878-82
pubmed: 12231501
J Physiol. 2015 Apr 15;593(8):1965-79
pubmed: 25652549
Exerc Sport Sci Rev. 2008 Jul;36(3):109-15
pubmed: 18580290
J Appl Physiol (1985). 1990 Feb;68(2):544-8
pubmed: 2318766
J Appl Physiol (1985). 1997 May;82(5):1573-83
pubmed: 9134907
J Physiol. 2019 Aug;597(16):4193-4202
pubmed: 31290158
Science. 1929 Aug 30;70(1809):200-4
pubmed: 17732865
Br J Sports Med. 2012 May;46(6):397-401
pubmed: 22267570