Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid.

Mice Animals Gastrointestinal Microbiome Biological Availability Hyaluronic Acid / pharmacology Molecular Weight Skin / metabolism
Bioavailability Digestion Hyaluronan Metabolism Microbiota Oligosaccharides

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Aug 2023
Historique:
received: 01 02 2023
revised: 09 03 2023
accepted: 30 03 2023
medline: 16 5 2023
pubmed: 15 5 2023
entrez: 14 5 2023
Statut: ppublish

Résumé

The ability of hyaluronan as a dietary supplement to increase skin moisture and relieve knee pain has been demonstrated in several clinical studies. To understand the mechanism of action, determining hyaluronan's bioavailability and in vivo fate is crucial. Here, we used

Identifiants

DOI: 10.1016/j.carbpol.2023.120880 PMID: 37182970
pubmed: 37182970
pii: S0144-8617(23)00345-4
doi: 10.1016/j.carbpol.2023.120880
pii:
doi:

Substances chimiques

Hyaluronic Acid 9004-61-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120880

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing interests.

Auteurs

Matěj Šimek (M)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic. Electronic address: matej.simek@contipro.com.

Kristýna Turková (K)

International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.

Martin Schwarzer (M)

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic.

Kristina Nešporová (K)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic.

Lukáš Kubala (L)

International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Martina Hermannová (M)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic.

Tereza Foglová (T)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic.

Barbora Šafránková (B)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic.

Martin Šindelář (M)

Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Dagmar Šrůtková (D)

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic.

Sofia Chatzigeorgiou (S)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic; Institute of Immunology and Microbiology, 1(st) Faculty of Medicine, Charles University, Prague, Czech Republic.

Tereza Novotná (T)

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic.

Tomáš Hudcovic (T)

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic.

Vladimír Velebný (V)

Contipro a.s., Dolní Dobrouč 401, 56102 Dolní Dobrouč, Czech Republic.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Eucaryotes › Animaux › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Acide hyaluronique › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › Molecular weight and gut microbiota determine...
questionsmedicales.fr › Système tégumentaire › Peau › Molecular weight and gut microbiota determine...