Neopterin Levels in Bonobos Vary Seasonally and Reflect Symptomatic Respiratory Infections.
Ecoimmunology
Health monitoring
Non-invasive
Pan paniscus
Respiratory infections
Seasonal infectious diseases
Urinary neopterin
Journal
EcoHealth
ISSN: 1612-9210
Titre abrégé: Ecohealth
Pays: United States
ID NLM: 101222144
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
10
02
2022
accepted:
05
03
2023
revised:
27
02
2023
medline:
12
6
2023
pubmed:
15
5
2023
entrez:
15
5
2023
Statut:
ppublish
Résumé
As environmental changes exacerbate the threat coming from infectious diseases in wild mammal species, monitoring their health and gaining a better understanding of the immune functioning at the species level have become critically important. Neopterin is a biomarker of cell-mediated immune responses to intracellular infections. We investigated the variation of urinary neopterin (uNeo) levels of wild, habituated bonobos (Pan paniscus) in relation to individual and environmental factors. We used 309 urine samples collected between 2010 and 2018 at the LuiKotale field site, DRC. Based on current knowledge on zoo-housed conspecifics and closely related species, we predicted uNeo levels to increase (1) during infections, (2) with increasing age, (3) over the gestation period and in estrous females; and (4) to vary seasonally. Our results showed uNeo levels varied over a one-year period and increased in individuals showing respiratory symptoms. Contrary to chimpanzees, uNeo levels did not vary with age or female reproductive status, possibly due to our small sample size. Our study provides a baseline for a better understanding of bonobo's immunocompetence in the context of socio-ecological pressures and for monitoring the health of wild populations.
Identifiants
pubmed: 37184594
doi: 10.1007/s10393-023-01633-y
pii: 10.1007/s10393-023-01633-y
pmc: PMC10257626
doi:
Substances chimiques
Neopterin
670-65-5
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-104Informations de copyright
© 2023. The Author(s).
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