Early life nutrition affects the molecular ontogeny of testicular development in the young bull calf.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
06
05
2022
accepted:
04
11
2022
medline:
17
5
2023
pubmed:
15
5
2023
entrez:
15
5
2023
Statut:
epublish
Résumé
Enhanced early life nutrition accelerates sexual development in the bull calf through neuroendocrine-signalling mediated via the hypothalamic-pituitary-testicular axis. Our aim was to assess the impact of contrasting feeding regimes in bull calves during the first 12 weeks of life on the testes transcriptome and proteome. Holstein-Friesian bull calves were offered either a high (HI) or moderate (MOD) plane of nutrition, designed to support target growth rates of 1.0 and 0.5 kg/day, respectively. At 12 weeks of age all calves were euthanized, testicular parenchyma sampled, and global transcriptome (miRNAseq and mRNAseq) and proteome analyses undertaken. Bioinformatic analyses revealed 7 differentially expressed (DE) miRNA and 20 DE mRNA. There were no differentially abundant proteins between the two dietary groups. Integration of omics results highlighted a potential role for the cadherin gene, CDH13, in earlier reproductive development. Furthermore, co-regulatory network analysis of the proteomic data revealed CDH13 as a hub protein within a network enriched for processes related to insulin, IGF-1, androgen and Sertoli cell junction signalling pathways as well as cholesterol biosynthesis. Overall, results highlight a potential role for CDH13 in mediating earlier reproductive development as a consequence of enhanced early life nutrition in the bull calf.
Identifiants
pubmed: 37185277
doi: 10.1038/s41598-022-23743-3
pii: 10.1038/s41598-022-23743-3
pmc: PMC10130005
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6748Informations de copyright
© 2023. The Author(s).
Références
Sci Rep. 2019 Apr 23;9(1):6448
pubmed: 31015481
Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C475-85
pubmed: 22700795
Domest Anim Endocrinol. 2007 Jul;33(1):1-18
pubmed: 16677793
Sci Rep. 2018 Nov 8;8(1):16577
pubmed: 30409985
J Anim Sci. 2021 Aug 1;99(8):
pubmed: 34175920
Sci Rep. 2018 Jan 12;8(1):592
pubmed: 29330490
J Dairy Sci. 1983 Dec;66(12):2606-22
pubmed: 6365992
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Gene Expr Patterns. 2003 Aug;3(4):449-54
pubmed: 12915310
J Neurosci. 2000 Aug 1;20(15):5671-8
pubmed: 10908605
Immunol Rev. 2011 Nov;244(1):5-8
pubmed: 22017427
J Mater Sci Mater Med. 2003 Nov;14(11):1005-9
pubmed: 15348515
J Dairy Sci. 2018 Apr;101(4):3460-3475
pubmed: 29397166
Reprod Biol Endocrinol. 2004 Mar 10;2:9
pubmed: 15012831
Animal. 2022 May;16(5):100527
pubmed: 35500509
BMC Genomics. 2009 Aug 27;10:405
pubmed: 19712483
J Cell Biochem. 2014 Feb;115(2):232-42
pubmed: 24038201
Sci Rep. 2015 May 21;5:10372
pubmed: 25996545
Cell Rep. 2018 Jul 31;24(5):1330-1341
pubmed: 30067986
Bioinformatics. 2014 Feb 15;30(4):523-30
pubmed: 24336805
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Purinergic Signal. 2006 Jun;2(2):391-8
pubmed: 18404478
Biol Open. 2015 Jan 23;4(2):212-23
pubmed: 25617420
J Dairy Sci. 2015 Feb;98(2):987-98
pubmed: 25497791
Reproduction. 2018 Oct 01;156(4):283-297
pubmed: 30305241
J Androl. 1994 Sep-Oct;15(5):381-5
pubmed: 7860417
Reproduction. 2020 Sep;160(3):405-415
pubmed: 32567558
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Theriogenology. 2016 Aug;86(3):687-694.e2
pubmed: 27114168
Animal. 2018 Jun;12(s1):s36-s44
pubmed: 29554994
Asian J Androl. 2008 Jul;10(4):569-76
pubmed: 18478160
Int J Mol Sci. 2020 May 28;21(11):
pubmed: 32481702
Reprod Domest Anim. 2008 Jul;43 Suppl 2:295-301
pubmed: 18638138
Biochem J. 1992 Jul 15;285 ( Pt 2):345-65
pubmed: 1637327
Annu Rev Biochem. 1980;49:357-93
pubmed: 6996567