Ultrasound elastography in chronic kidney disease: a systematic review and meta-analysis.

Chronic kidney disease Kidney elasticity Kidney elastography Shear wave elastography Transplantation Ultrasound elastography

Journal

Journal of medical ultrasonics (2001)
ISSN: 1613-2254
Titre abrégé: J Med Ultrason (2001)
Pays: Japan
ID NLM: 101128385

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 16 11 2022
accepted: 07 03 2023
medline: 21 7 2023
pubmed: 15 5 2023
entrez: 15 5 2023
Statut: ppublish

Résumé

Ultrasound elastography (USE) is a noninvasive technique for assessing tissue elasticity, and its application in nephrology has aroused growing interest in recent years. The purpose of this article is to systematically review the clinical application of USE in patients with chronic kidney disease (CKD), including native and transplanted kidneys, and quantitatively investigate differences in elasticity values between healthy individuals and CKD patients. Furthermore, we provide a qualitative analysis of the studies included, discussing the potential interplay between renal stiffness, estimated glomerular filtration rate, and fibrosis. In January 2022, a systematic search was carried out on the MEDLINE (PubMed) database, concerning studies on the application of USE in patients with CKD, including patients with transplanted kidneys. The results of the included studies were extracted by two independent researchers and presented mainly through a formal narrative summary. A meta-analysis of nine study parts from six studies was performed. A total of 647 studies were screened for eligibility and, after applying the exclusion and inclusion criteria, 69 studies were included, for a total of 6728 patients. The studies proved very heterogeneous in terms of design and results. The shear wave velocity difference of - 0.82 m/s (95% CI: - 1.72-0.07) between CKD patients and controls was not significant. This result agrees with the qualitative evaluation of included studies that found controversial results for the relationship between renal stiffness and glomerular filtration rate. On the contrary, a clear relationship seems to emerge between USE values and the degree of fibrosis. At present, due to the heterogeneity of results and technical challenges, large-scale application in the monitoring of CKD patients remains controversial.

Identifiants

pubmed: 37186192
doi: 10.1007/s10396-023-01304-z
pii: 10.1007/s10396-023-01304-z
doi:

Types de publication

Meta-Analysis Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

381-415

Informations de copyright

© 2023. The Author(s), under exclusive licence to The Japan Society of Ultrasonics in Medicine.

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Auteurs

Maurizio Cè (M)

Postgraduate School in Diagnostic and Interventional Radiology, University of Milan, Milan, Italy. maurizioce.md1@gmail.com.

Paolo Florent Felisaz (PF)

Division of Radiology, ASST Fatebenefratelli Sacco, Fatebenefratelli Hospital, Milan, Italy.

Marco Alì (M)

Centro Diagnostico Italiano, Milan, Italy.
Bracco Imaging S.P.A., Milan, Italy.

Giulia Vanessa Re Sartò (GV)

Division of Nephrology and Dialysis, ASST Fatebenefratelli Sacco, Fatebenefratelli Hospital, Milan, Italy.

Michaela Cellina (M)

Division of Radiology, ASST Fatebenefratelli Sacco, Fatebenefratelli Hospital, Milan, Italy.

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