Synthesis and Preclinical Positron Emission Tomography Imaging of the p38 MAPK Inhibitor [
MAPK p38α/β
PET
neurodegenerative disease
talmapimod
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
07 06 2023
07 06 2023
Historique:
medline:
8
6
2023
pubmed:
15
5
2023
entrez:
15
5
2023
Statut:
ppublish
Résumé
Stress-activated kinases are targets of interest in neurodegenerative disease due to their involvement in inflammatory signaling and synaptic dysfunction. The p38α kinase has shown clinical and preclinical promise as a druggable target in several neurodegenerative conditions. We report the radiosynthesis and evaluation of the first positron emission tomography (PET) radiotracer for imaging MAPK p38α/β through radiolabeling of the inhibitor talmapimod (SCIO-469) with carbon-11. [
Identifiants
pubmed: 37186961
doi: 10.1021/acschemneuro.3c00205
doi:
Substances chimiques
Carbon-11
0
Carbon Radioisotopes
0
Protein Kinase Inhibitors
0
Radiopharmaceuticals
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2193-2200Subventions
Organisme : CIHR
Pays : Canada