Development and testing of a polygenic risk score for breast cancer aggressiveness.
Journal
NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166
Informations de publication
Date de publication:
15 May 2023
15 May 2023
Historique:
received:
13
10
2022
accepted:
28
04
2023
medline:
16
5
2023
pubmed:
16
5
2023
entrez:
15
5
2023
Statut:
epublish
Résumé
Aggressive breast cancers portend a poor prognosis, but current polygenic risk scores (PRSs) for breast cancer do not reliably predict aggressive cancers. Aggressiveness can be effectively recapitulated using tumor gene expression profiling. Thus, we sought to develop a PRS for the risk of recurrence score weighted on proliferation (ROR-P), an established prognostic signature. Using 2363 breast cancers with tumor gene expression data and single nucleotide polymorphism (SNP) genotypes, we examined the associations between ROR-P and known breast cancer susceptibility SNPs using linear regression models. We constructed PRSs based on varying p-value thresholds and selected the optimal PRS based on model r
Identifiants
pubmed: 37188791
doi: 10.1038/s41698-023-00382-z
pii: 10.1038/s41698-023-00382-z
pmc: PMC10185660
doi:
Types de publication
Journal Article
Langues
eng
Pagination
42Subventions
Organisme : NCI NIH HHS
ID : U01 CA195565
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA237829
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA129059
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA105274
Pays : United States
Organisme : NCI NIH HHS
ID : K24 CA169004
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA210961
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA196406
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Nat Genet. 2013 Apr;45(4):353-61, 361e1-2
pubmed: 23535729
Nature. 2002 Jan 31;415(6871):530-6
pubmed: 11823860
Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):658-69
pubmed: 24493630
Ann Oncol. 2016 Jun;27(6):1181
pubmed: 26945009
PLoS One. 2014 Dec 19;9(12):e101488
pubmed: 25526632
J Pers Med. 2021 Jun 04;11(6):
pubmed: 34199804
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
N Engl J Med. 2004 Dec 30;351(27):2817-26
pubmed: 15591335
Immunity. 2021 Feb 9;54(2):367-386.e8
pubmed: 33567262
N Engl J Med. 2006 Aug 10;355(6):560-9
pubmed: 16899776
Nat Genet. 2017 Dec;49(12):1767-1778
pubmed: 29058716
J Clin Oncol. 2023 Apr 1;41(10):1849-1863
pubmed: 36689693
Clin Pharmacol Ther. 2009 Jul;86(1):97-100
pubmed: 19440188
PLoS One. 2015 Apr 13;10(4):e0122413
pubmed: 25867717
Nat Genet. 2015 Apr;47(4):373-80
pubmed: 25751625
Front Genet. 2016 Sep 21;7:170
pubmed: 27708667
Cancer Causes Control. 2008 Dec;19(10):1065-76
pubmed: 18478338
J Natl Cancer Inst. 2015 Apr 18;107(5):
pubmed: 25890600
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Am J Hum Genet. 2019 Jan 3;104(1):21-34
pubmed: 30554720
PLoS Comput Biol. 2020 Oct 1;16(10):e1008271
pubmed: 33001975
Breast Cancer Res. 2017 Nov 14;19(1):120
pubmed: 29137653
JAMA Oncol. 2018 Apr 01;4(4):545-553
pubmed: 29450494
Nat Commun. 2019 Oct 22;10(1):4648
pubmed: 31641120
Cancer Res. 2013 Mar 15;73(6):1883-91
pubmed: 23319801
J Clin Oncol. 2009 Mar 10;27(8):1160-7
pubmed: 19204204
Breast Cancer Res Treat. 2016 Oct;159(3):513-25
pubmed: 27565998
J Clin Oncol. 2009 Sep 20;27(27):4515-21
pubmed: 19704069
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012
pubmed: 30445434
J Clin Oncol. 2007 Apr 1;25(10):1239-46
pubmed: 17401012
Breast Cancer Res. 2022 Jan 4;24(1):2
pubmed: 34983606
BMC Med Genomics. 2012 Oct 04;5:44
pubmed: 23035882
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
J Natl Cancer Inst. 2017 Jan 27;109(5):
pubmed: 28130475
Breast. 2015 Nov;24 Suppl 2:S26-35
pubmed: 26253814
Clin Cancer Res. 2010 Nov 1;16(21):5222-32
pubmed: 20837693
BMC Cancer. 2022 May 6;22(1):507
pubmed: 35524202
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
pubmed: 11553815
Cancer Epidemiol Biomarkers Prev. 2014 May;23(5):725-34
pubmed: 24521998
Nat Genet. 2020 Jun;52(6):572-581
pubmed: 32424353
Carcinogenesis. 2014 May;35(5):1012-9
pubmed: 24325915
Cancer Res. 2022 Jan 1;82(1):25-35
pubmed: 34711612
Am J Hum Genet. 2020 Sep 3;107(3):432-444
pubmed: 32758450
NPJ Precis Oncol. 2022 May 30;6(1):32
pubmed: 35637246
PLoS One. 2017 Jan 20;12(1):e0168601
pubmed: 28107349
NPJ Breast Cancer. 2022 Mar 23;8(1):39
pubmed: 35322040
N Engl J Med. 2002 Dec 19;347(25):1999-2009
pubmed: 12490681
J Clin Oncol. 2017 Mar;35(7):743-750
pubmed: 28029312
Bioinformatics. 2015 Nov 1;31(21):3555-7
pubmed: 26139635
Nature. 2017 Nov 2;551(7678):92-94
pubmed: 29059683
Cancer Res. 2020 May 1;80(9):1893-1901
pubmed: 32245796
Cancer Res. 2012 Mar 1;72(5):1182-9
pubmed: 22232737
Nature. 2012 Apr 18;486(7403):346-52
pubmed: 22522925
J Clin Oncol. 2016 Jan 20;34(3):251-8
pubmed: 26628467