Frequency of pleural effusion in dengue patients by severity, age and imaging modality: a systematic review and meta-analysis.
Dengue fever
Plasma leakage
Pleural effusion
Ultrasound
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
15 May 2023
15 May 2023
Historique:
received:
17
02
2023
accepted:
06
05
2023
medline:
17
5
2023
pubmed:
16
5
2023
entrez:
15
5
2023
Statut:
epublish
Résumé
Identification of pleural effusion (PE) in dengue infection is an objective measure of plasma leakage and may predict disease progression. However, no studies have systematically assessed the frequency of PE in patients with dengue, and whether this differs across age and imaging modality. We searched Pubmed, Embase Web of Science and Lilacs (period 1900-2021) for studies reporting on PE in dengue patients (hospitalized and outpatient). We defined PE as fluid in the thoracic cavity detected by any imaging test. The study was registered in PROSPERO (CRD42021228862). Complicated dengue was defined as hemorrhagic fever, dengue shock syndrome or severe dengue. The search identified 2,157 studies of which 85 studies were eligible for inclusion. The studies (n = 31 children, n = 10 adults, n = 44 mixed age) involved 12,800 patients (30% complicated dengue). The overall frequency of PE was 33% [95%CI: 29 to 37%] and the rate of PE increased significantly with disease severity (P = 0.001) such that in complicated vs. uncomplicated dengue the frequencies were 48% and 17% (P < 0.001). When assessing all studies, PE occurred significantly more often in children compared to adults (43% vs. 13%, P = 0.002) and lung ultrasound more frequently detected PE than conventional chest X-ray (P = 0.023). We found that 1/3 of dengue patients presented with PE and the frequency increased with severity and younger age. Importantly, lung ultrasound demonstrated the highest rate of detection. Our findings suggest that PE is a relatively common finding in dengue and that bedside imaging tools, such as lung ultrasound, potentially may enhance detection.
Sections du résumé
BACKGROUND
BACKGROUND
Identification of pleural effusion (PE) in dengue infection is an objective measure of plasma leakage and may predict disease progression. However, no studies have systematically assessed the frequency of PE in patients with dengue, and whether this differs across age and imaging modality.
METHODS
METHODS
We searched Pubmed, Embase Web of Science and Lilacs (period 1900-2021) for studies reporting on PE in dengue patients (hospitalized and outpatient). We defined PE as fluid in the thoracic cavity detected by any imaging test. The study was registered in PROSPERO (CRD42021228862). Complicated dengue was defined as hemorrhagic fever, dengue shock syndrome or severe dengue.
RESULTS
RESULTS
The search identified 2,157 studies of which 85 studies were eligible for inclusion. The studies (n = 31 children, n = 10 adults, n = 44 mixed age) involved 12,800 patients (30% complicated dengue). The overall frequency of PE was 33% [95%CI: 29 to 37%] and the rate of PE increased significantly with disease severity (P = 0.001) such that in complicated vs. uncomplicated dengue the frequencies were 48% and 17% (P < 0.001). When assessing all studies, PE occurred significantly more often in children compared to adults (43% vs. 13%, P = 0.002) and lung ultrasound more frequently detected PE than conventional chest X-ray (P = 0.023).
CONCLUSIONS
CONCLUSIONS
We found that 1/3 of dengue patients presented with PE and the frequency increased with severity and younger age. Importantly, lung ultrasound demonstrated the highest rate of detection. Our findings suggest that PE is a relatively common finding in dengue and that bedside imaging tools, such as lung ultrasound, potentially may enhance detection.
Identifiants
pubmed: 37189054
doi: 10.1186/s12879-023-08311-y
pii: 10.1186/s12879-023-08311-y
pmc: PMC10184094
doi:
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
327Subventions
Organisme : Novo Nordisk Fonden
ID : NNF20OC0062782
Organisme : Hjerteforeningen
ID : 20-R139-A9644-22165
Organisme : William Demant Fonden
ID : 20-1257
Organisme : Knud Højgaards Fond
ID : 20-01-1076
Organisme : Knud Højgaards Fond
ID : 18-05-2487
Organisme : Knud Højgaards Fond
ID : 18-05-2487
Organisme : Reinholdt W. Jorck og Hustrus Fond
ID : 20-JU-0145
Organisme : Reinholdt W. Jorck og Hustrus Fond
ID : 18-JU-0485
Organisme : Reinholdt W. Jorck og Hustrus Fond
ID : 18-JU-0485
Organisme : Danmarks Frie Forskningsfond
ID : 0129-0003B
Organisme : Danmarks Frie Forskningsfond
ID : 0129-0003B
Organisme : Dansk Medicinsk Selskab, København
ID : 120620-kms
Organisme : Dansk Medicinsk Selskab, København
ID : 120620-kms
Organisme : A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal
ID : 18-L-0026
Organisme : A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal
ID : 18-L-0026
Organisme : Eva og Henrik Frænkels Mindefond
ID : NLA-080919
Organisme : Eva og Henrik Frænkels Mindefond
ID : NLA-080919
Organisme : Torben og Alice Frimodts Fond
ID : TA250419
Organisme : Torben og Alice Frimodts Fond
ID : TA250419
Organisme : Brorsons Fond
ID : 12038-1-hh
Organisme : Brorsons Fond
ID : 12038-1-hh
Organisme : Lundbeckfonden
ID : R373-2021-1201
Organisme : Lundbeckfonden
ID : R373-2021-1201
Informations de copyright
© 2023. The Author(s).
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