D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice.
D-aspartate
D-aspartate oxidase
DAAM1
PREP
knockin mice
spermatogenesis
steroidogenesis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
30 03 2023
30 03 2023
Historique:
received:
21
02
2023
revised:
23
03
2023
accepted:
28
03
2023
medline:
17
5
2023
pubmed:
16
5
2023
entrez:
16
5
2023
Statut:
epublish
Résumé
High levels of free D-aspartate (D-Asp) are present in vertebrate testis during post-natal development, coinciding with the onset of testosterone production, which suggests that this atypical amino acid might participate in the regulation of hormone biosynthesis. To elucidate the unknown role of D-Asp on testicular function, we investigated steroidogenesis and spermatogenesis in a one-month-old knockin mouse model with the constitutive depletion of D-Asp levels due to the targeted overexpression of D-aspartate oxidase (DDO), which catalyzes the deaminative oxidation of D-Asp to generate the corresponding α-keto acid, oxaloacetate, hydrogen peroxide, and ammonium ions. In the
Identifiants
pubmed: 37189369
pii: biom13040621
doi: 10.3390/biom13040621
pmc: PMC10136051
pii:
doi:
Substances chimiques
Aspartic Acid
30KYC7MIAI
D-Aspartic Acid
4SR0Q8YD1X
Testosterone
3XMK78S47O
Prolyl Oligopeptidases
EC 3.4.21.26
Daam1 protein, mouse
EC 3.6.1.-
Microfilament Proteins
0
rho GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Exp Biol. 2012 Oct 15;215(Pt 20):3559-65
pubmed: 22771744
Arch Biochem Biophys. 1998 Mar 1;351(1):96-105
pubmed: 9500846
Amino Acids. 2020 Sep;52(9):1263-1273
pubmed: 32930873
J Cell Physiol. 2016 Oct;231(10):2172-84
pubmed: 26831620
Biology (Basel). 2020 Sep 04;9(9):
pubmed: 32899860
J Histochem Cytochem. 2019 Apr;67(4):229-243
pubmed: 30380361
Theriogenology. 2014 Mar 15;81(5):744-51
pubmed: 24439162
Transl Psychiatry. 2022 Aug 1;12(1):305
pubmed: 35915065
Reprod Fertil Dev. 2020 Mar;32(5):484-494
pubmed: 31972124
J Endocrinol Invest. 2016 Feb;39(2):207-13
pubmed: 26122485
Amino Acids. 2020 Apr;52(4):597-617
pubmed: 32185508
Brain Res Rev. 2007 Feb;53(2):215-34
pubmed: 17118457
J Cell Physiol. 2016 Feb;231(2):490-5
pubmed: 26189884
Front Cell Dev Biol. 2023 Mar 09;11:1145702
pubmed: 36968197
Genes (Basel). 2021 Jun 30;12(7):
pubmed: 34208970
Steroids. 2014 Jun;84:103-10
pubmed: 24713504
Antioxidants (Basel). 2021 Jan 12;10(1):
pubmed: 33445610
Comp Biochem Physiol B. 1993 Jul-Aug;105(3-4):731-4
pubmed: 8103425
Int J Mol Sci. 2016 Jul 14;17(7):
pubmed: 27428949
Int J Mol Sci. 2020 Nov 18;21(22):
pubmed: 33218144
Reprod Biol. 2022 Mar;22(1):100601
pubmed: 35032869
FASEB J. 2000 Apr;14(5):699-714
pubmed: 10744627
Reproduction. 2019 Oct;158(4):357-367
pubmed: 31398714
J Cell Biochem. 2019 Jul;120(7):11044-11055
pubmed: 30762900
Ann Endocrinol (Paris). 2014 May;75(2):40-7
pubmed: 24793988
Amino Acids. 2014 Aug;46(8):1805-18
pubmed: 24839076
FEBS Lett. 1999 Feb 12;444(2-3):160-4
pubmed: 10050750
FEBS Lett. 1998 Sep 25;436(1):23-7
pubmed: 9771887
NPJ Schizophr. 2017 Apr 6;3:16
pubmed: 28560262
Fertil Steril. 2005 Nov;84(5):1444-9
pubmed: 16275242
Biomolecules. 2019 Sep 03;9(9):
pubmed: 31484465
Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1129-1140
pubmed: 28629864
Reproduction. 2019 Feb;157(2):R53-R72
pubmed: 30576284
J Exp Zool B Mol Dev Evol. 2019 Sep;332(6):198-209
pubmed: 31433565
C R Biol. 2018 Jan;341(1):9-15
pubmed: 29203165
Biochim Biophys Acta Proteins Proteom. 2020 Oct;1868(10):140471
pubmed: 32561430
J Biol Chem. 1994 Apr 29;269(17):12626-32
pubmed: 8175672
Biomolecules. 2020 Apr 28;10(5):
pubmed: 32353957
Mol Reprod Dev. 2020 May;87(5):565-573
pubmed: 32329151
Endocrinology. 1999 Oct;140(10):4609-15
pubmed: 10499517
Gen Comp Endocrinol. 2013 Jan 15;181:72-6
pubmed: 23153651
Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):943-64
pubmed: 15306409
Biol Reprod. 2016 Feb;94(2):30
pubmed: 26658710
FEBS Lett. 1999 Jul 9;454(3):317-20
pubmed: 10431830
Reprod Fertil Dev. 2016 Oct;28(12):1865-1872
pubmed: 26044185
Zoolog Sci. 2002 Jan;19(1):93-102
pubmed: 12025410
Int J Mol Sci. 2021 Jul 28;22(15):
pubmed: 34360857
Exp Neurol. 2019 Jul;317:51-65
pubmed: 30822420
J Cell Physiol. 2016 Mar;231(3):551-7
pubmed: 26332268
Comp Biochem Physiol A Mol Integr Physiol. 2016 Jan;191:180-186
pubmed: 26517944