Effects of Melatonin Alone or Associated with Acyclovir on the Suppressive Treatment of Recurrent Genital Herpes: A Prospective, Randomized, and Double-Blind Study.
acyclovir
genital herpes
melatonin
quality of life
questionnaires
recurrence
viruses
women
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
04 Apr 2023
04 Apr 2023
Historique:
received:
06
02
2023
revised:
20
03
2023
accepted:
28
03
2023
medline:
16
5
2023
pubmed:
16
5
2023
entrez:
16
5
2023
Statut:
epublish
Résumé
Suppressive therapy of recurrent genital herpes is a challenge, and melatonin may be an alternative. To evaluate the action of melatonin, acyclovir, or the association of melatonin with acyclovir as a suppressive treatment in women with recurrent genital herpes. The study was prospective, double-blind, and randomized, including 56 patients as follows: (a) The melatonin group received 180 placebo capsules in the 'day' container and 180 melatonin 3 mg capsules in the 'night' container ( No statistically significant difference was observed for the depression and sleepiness questionnaires. However, in the Lanns scale for pain, all groups decreased the mean and median values in time ( Our data suggest that melatonin may be an option for the suppressive treatment of recurrent genital herpes.
Identifiants
pubmed: 37189706
pii: biomedicines11041088
doi: 10.3390/biomedicines11041088
pmc: PMC10135732
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : São Paulo Research Foundation
ID : 2018/24224-9
Organisme : National Council for Scientific and Technological Development
ID : 304264/2021-0
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