Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma.

Humans Animals Mice Carcinoma, Renal Cell / pathology Nucleosides / therapeutic use Reproducibility of Results Transcriptome Von Hippel-Lindau Tumor Suppressor Protein / genetics Kidney Neoplasms / pathology RNA / therapeutic use
HPLC RNA-seq biomarker discovery biomarkers ccRCC kidney cancer mass spectrometry metabolomics modified nucleosides transcriptomics

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
07 04 2023
Historique:
received: 10 03 2023
revised: 30 03 2023
accepted: 05 04 2023
medline: 17 5 2023
pubmed: 16 5 2023
entrez: 16 5 2023
Statut: epublish

Résumé

Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (

Identifiants

DOI: 10.3390/cells12081102 PMID: 37190010 PMC: PMC10136813
pubmed: 37190010
pii: cells12081102
doi: 10.3390/cells12081102
pmc: PMC10136813
pii:
doi:

Substances chimiques

Nucleosides 0
Von Hippel-Lindau Tumor Suppressor Protein EC 2.3.2.27
RNA 63231-63-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Daniel A Mohl (DA)

Core Competence Metabolomics, Hilde-Mangold-Haus, University of Freiburg, 79104 Freiburg, Germany.
Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0001-6915-4946

Simon Lagies (S)

Core Competence Metabolomics, Hilde-Mangold-Haus, University of Freiburg, 79104 Freiburg, Germany.
Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany.
Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center-University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0002-5245-1781

Kyra Zodel (K)

Department of Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-6581-3972

Matthias Zumkeller (M)

Department of Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.

Asin Peighambari (A)

Department of Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.

Athina Ganner (A)

Renal Division, Department of Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-6455-5641

Dietmar A Plattner (DA)

Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany.

Elke Neumann-Haefelin (E)

Renal Division, Department of Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Mojca Adlesic (M)

Department of Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.

Ian J Frew (IJ)

Department of Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Signalling Research Centre BIOSS, University of Freiburg, 79104 Freiburg, Germany.
Comprehensive Cancer Center Freiburg (CCCF), Faculty of Medicine and Medical Center-University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0003-2735-5509

Bernd Kammerer (B)

Core Competence Metabolomics, Hilde-Mangold-Haus, University of Freiburg, 79104 Freiburg, Germany.
Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany.
Signalling Research Centre BIOSS, University of Freiburg, 79104 Freiburg, Germany.
Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Eucaryotes › Animaux › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › Néphrocarcinome › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéine Von Hippel-Lindau supresseur de tumeur › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › Integrated Metabolomic and Transcriptomic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Integrated Metabolomic and Transcriptomic...