A Historical Overview on the Role of Hepatitis B and C Viruses as Aetiological Factors for Hepatocellular Carcinoma.
HBV
HCC
HCV
prevention
risk factors
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Apr 2023
20 Apr 2023
Historique:
received:
27
03
2023
revised:
14
04
2023
accepted:
19
04
2023
medline:
16
5
2023
pubmed:
16
5
2023
entrez:
16
5
2023
Statut:
epublish
Résumé
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the leading cause of hepatocellular carcinoma (HCC) worldwide. Currently, HBV-related HCC predominates in Sub-Saharan Africa and South-East-Asia, while HCV-related HCC predominates in northern Africa and in the western world. Liver cirrhosis is the underlying condition in most HBV cases and in nearly all HCV cases. Several cofactors, viral and non-viral, play a role in the progression toward HCC: dual HBV/HCV infection, HDV, HIV, alcohol intake, smoking, diabetes mellitus, obesity, and NAFLD/NASH. HBV vaccine is effective in preventing both infection and HCC; antiviral drugs may suppress HBV replication and eradicate HCV infection, halting progression to HCC. Inequalities exist between high- and low-income countries with respect to vaccine availability and access to antivirals. These factors represent barriers to the control of HCC incidence. Lack of an effective vaccine against HCV is also a serious barrier to HCV elimination and HCC prevention. The most crucial steps and knowledge that have arisen over time on the association between the two major hepatotropic viruses and HCC are discussed in this historical review.
Identifiants
pubmed: 37190317
pii: cancers15082388
doi: 10.3390/cancers15082388
pmc: PMC10136487
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : Fondi Ricerca Corrente
Références
Gut. 2003 Feb;52(2):288-92
pubmed: 12524415
Aliment Pharmacol Ther. 2017 Nov;46(9):856-863
pubmed: 28857208
Lancet. 1997 Mar 22;349(9055):825-32
pubmed: 9121257
Int J Cancer. 1999 May 31;81(5):695-9
pubmed: 10328218
J Natl Cancer Inst. 1990 Jun 20;82(12):1038-41
pubmed: 2161463
Clin Liver Dis. 2019 Aug;23(3):535-555
pubmed: 31266626
Gut. 2000 Mar;46(3):420-6
pubmed: 10673308
Int J Cancer. 2018 Apr 15;142(8):1560-1567
pubmed: 29193051
JAMA Oncol. 2017 Dec 1;3(12):1683-1691
pubmed: 28983565
N Engl J Med. 1980 Oct 9;303(15):833-41
pubmed: 6997738
Lancet. 1981 Nov 21;2(8256):1129-33
pubmed: 6118576
J Hepatol. 1992 Nov;16(3):360-3
pubmed: 1336785
J Infect Dis. 2021 Sep 1;224(5):804-812
pubmed: 33903902
J Transl Med. 2019 Jan 3;17(1):7
pubmed: 30602391
Ann Intern Med. 1992 Jan 15;116(2):97-102
pubmed: 1309286
JAMA. 1965 Feb 15;191:541-6
pubmed: 14239025
BMC Med Genomics. 2019 Oct 28;12(1):147
pubmed: 31660973
Hepatology. 2007 Jul;46(1):48-57
pubmed: 17596875
Lancet. 1981 Oct 10;2(8250):765-8
pubmed: 6116901
Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1261-8
pubmed: 20447919
Arq Gastroenterol. 2013 Jan-Mar;50(1):19-22
pubmed: 23657302
J Interferon Cytokine Res. 2008 Nov;28(11):643-51
pubmed: 18844579
Am J Epidemiol. 2002 Feb 15;155(4):323-31
pubmed: 11836196
Dig Dis Sci. 2016 Feb;61(2):636-45
pubmed: 26703125
Gastroenterology. 2019 Aug;157(2):537-551.e9
pubmed: 30978357
Gut. 2023 Jan;72(1):141-152
pubmed: 34933916
Hepatology. 2019 Feb;69(2):487-497
pubmed: 28749564
J Hepatol. 2016 Apr;64(1 Suppl):S102-S116
pubmed: 27084031
Hepatology. 1999 Jul;30(1):271-6
pubmed: 10385666
Gastroenterology. 2018 Aug;155(2):411-421.e4
pubmed: 29655836
Ann Intern Med. 2017 May 02;166(9):637-648
pubmed: 28319996
Gastroenterology. 2004 Nov;127(5 Suppl 1):S35-50
pubmed: 15508101
Hepatology. 1991 Feb;13(2):316-20
pubmed: 1847352
Ann Intern Med. 2013 Mar 5;158(5 Pt 1):329-37
pubmed: 23460056
World J Gastroenterol. 2014 May 28;20(20):5951-61
pubmed: 24876718
Nat Rev Gastroenterol Hepatol. 2020 Apr;17(4):238-251
pubmed: 31900465
J Gastroenterol Hepatol. 1990;5 Suppl 1:78-94
pubmed: 1966485
Am J Gastroenterol. 2008 Aug;103(8):1966-72
pubmed: 18637087
Hepatology. 2007 Mar;45(3):579-87
pubmed: 17326216
Clin Gastroenterol Hepatol. 2016 Jan;14(1):124-31.e1
pubmed: 26196445
J Hepatol. 2008 Oct;49(4):652-7
pubmed: 18715666
J Hepatol. 2015 Feb;62(2):469-76
pubmed: 25457207
Hepatology. 2017 Nov;66(5):1444-1453
pubmed: 28622419
Gastroenterology. 2019 Jun;156(8):2313-2329.e7
pubmed: 30836093
J Gastroenterol. 2002;37(11):883-7
pubmed: 12483242
Eur J Cancer. 2022 Jan;161:108-118
pubmed: 34942552
Epidemiol Rev. 2006;28:126-35
pubmed: 16782778
J Biol Regul Homeost Agents. 2003 Apr-Jun;17(2):144-6
pubmed: 14518713
Viruses. 2022 May 07;14(5):
pubmed: 35632728
Eur J Intern Med. 2018 Jul;53:79-84
pubmed: 29475770
Clin Infect Dis. 2001 Aug 15;33(4):562-9
pubmed: 11462196
Science. 1989 Apr 21;244(4902):362-4
pubmed: 2496467
Can J Gastroenterol Hepatol. 2018 Sep 23;2018:9151820
pubmed: 30345260
J Infect Dis. 2023 Mar 1;227(5):675-685
pubmed: 36546708
PLoS Genet. 2019 Jun 19;15(6):e1008181
pubmed: 31216276
Hepatology. 2009 May;49(5 Suppl):S13-21
pubmed: 19399811
Hepatology. 2019 Sep;70(3):939-954
pubmed: 30569448
J Hepatol. 2019 Aug;71(2):397-408
pubmed: 31004683
Infection. 2019 Oct;47(5):805-810
pubmed: 31028627
Cancer. 1999 May 15;85(10):2132-7
pubmed: 10326690
Viruses. 2022 Jan 26;14(2):
pubmed: 35215839
J Hepatol. 1998 Jun;28(6):930-8
pubmed: 9672166
Cell Discov. 2020 Dec 8;6(1):90
pubmed: 33298893
J Clin Med. 2021 Apr 16;10(8):
pubmed: 33923385
J Hepatol. 2017 Mar;66(3):645-654
pubmed: 27771453
Hepatology. 2011 Sep 2;54(3):801-7
pubmed: 21618565
Gut. 1977 Dec;18(12):997-1003
pubmed: 75123
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Cancer Manag Res. 2019 Jan 14;11:705-713
pubmed: 30679924
Am J Gastroenterol. 2023 Jan 1;118(1):95-104
pubmed: 36087102
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
J Hepatol. 2016 Sep;65(3):543-51
pubmed: 27180899
Hepatoma Res. 2021;7:
pubmed: 33614973
J Gastroenterol Hepatol. 2000 Jul;15(7):798-805
pubmed: 10937688
Cancer. 1989 Dec 1;64(11):2377-80
pubmed: 2553245
Dig Liver Dis. 2021 Oct;53(10):1315-1319
pubmed: 33162352
Gastroenterology. 2007 Feb;132(2):698-708
pubmed: 17258730
Clin Infect Dis. 2015 Aug 15;61(4):584-92
pubmed: 25904365
Hepatology. 2016 Mar;63(3):827-38
pubmed: 26599351
JAMA Oncol. 2018 May 1;4(5):737-739
pubmed: 29566141