Brain white-matter changes associated with symptomatic acute COVID-19 infection in the neonatal period.

COVID Magnetic resonance imaging Mri NEONATOLOGY Neonatal intensive care Neonatal neurology

Journal

IDCases
ISSN: 2214-2509
Titre abrégé: IDCases
Pays: Netherlands
ID NLM: 101634540

Informations de publication

Date de publication:
2023
Historique:
received: 08 04 2023
accepted: 07 05 2023
pubmed: 17 5 2023
medline: 17 5 2023
entrez: 16 5 2023
Statut: epublish

Résumé

We report an important case of periventricular white matter damage in a 1-month-old infant, demonstrated on high quality structural (T2) and diffusion weighted magnetic resonance imaging. The infant was born at term following an uneventful pregnancy and discharged home shortly after, but was brought to the paediatric emergency department five days after birth with seizures and respiratory distress, testing positive for COVID-19 infection on PCR. These images highlight the need to consider brain MRI in all infants with symptomatic SARS-Cov-2 infection, and show how this infection can lead to extensive white matter damage in the context of multisystem inflammation.

Identifiants

DOI: 10.1016/j.idcr.2023.e01796 PMID: 37193002 PMC: PMC10165867
pubmed: 37193002
doi: 10.1016/j.idcr.2023.e01796
pii: S2214-2509(23)00120-8
pmc: PMC10165867
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e01796

Subventions

Organisme : Medical Research Council
ID : MR/V036874/1
Pays : United Kingdom

Informations de copyright

© 2023 The Authors. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to disclose.

Auteurs

Daniel Cromb (D)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Department of Neonatology, Evelina London Children's Hospital, London, UK.

Tom Finck (T)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

Megan Quirke (M)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Paul Cawley (P)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Department of Neonatology, Evelina London Children's Hospital, London, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.

Amy Moran (A)

Department of Neonatology, Queen Elizabeth Hospital Woolwich, Lewisham and Greenwich NHS Trust, London, UK.

Olutoyin Banjoko (O)

Department of Neonatology, Queen Elizabeth Hospital Woolwich, Lewisham and Greenwich NHS Trust, London, UK.

Mary A Rutherford (MA)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.

Tomoki Arichi (T)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
Paediatric Neurosciences, Evelina London Children's Hospital, London, UK.

Classifications MeSH