Association of Perceived Social Support with Viral Suppression Among Young Adults with Perinatally-Acquired HIV in the US-based Pediatric HIV/AIDS Cohort Study (PHACS).

To determine the relationship between perceived social support and viral suppression among young adults with perinatally-acquired HIV (YAPHIV). We included YAPHIV ≥18 years enrolled in AMP Up, a study of PHACS (Pediatric HIV/AIDS Cohort Study), with social support evaluations and ≥1 HIV viral load (VL) measured over the next year. We evaluated emotional, instrumental, and friendship social support via the NIH Toolbox. We defined social support, measured at study entry and year 3 (if available), as low (T-score ≤40), average (41-59) or high (≥60). We defined viral suppression as all VL <50 copies/mL over the one year after social support measures. We fit multivariable Poisson regression models using generalized estimating equations, and evaluated transition from pediatric to adult care as an effect modifier. Among 444 YAPHIV, low emotional and instrumental support and friendship at entry were reported by 37%, 32% and 36%. Over the next year, 44% were virally suppressed. Of 136 with year 3 data, 45% were suppressed. Average or high levels of all three social support measures were associated with higher likelihood of viral suppression. Instrumental support was associated with viral suppression among those in pediatric (adjusted proportion suppressed among those with average/high vs low support=51.2% vs 28.9%; risk ratio (RR)=1.77, 95% confidence interval (CI)=1.37, 2.29), but not adult care (40.0% vs 40.8%; RR=0.98, 95% CI=0.67, 1.44). Sufficient social support increases likelihood of viral suppression among YAPHIV. Strategies to enhance social support may promote viral suppression as YAPHIV prepare for adult clinical care transition.

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© 2023 Tassiopoulos et al.

Déclaration de conflit d'intérêts

Dr Katherine Tassiopoulos, Ms Yanling Huo, Dr Deborah Kacanek, Dr Sharon Nichols and Dr Russell B Van Dyke report grants from the National Institutes of Health, during the conduct of the study; grants from the National Institutes of Health, outside the submitted work. Dr Kathleen Malee reports grants from the National Institutes of Health, during the conduct of the study. Dr Stephan Kohlhoff reports grants from the National Institutes of Health, during the conduct of the study; grants from Pfizer, grants from DiaSorin, outside the submitted work. The authors report no other conflicts of interest in this work.