Nutrients mediate caffeine inhibition of Escherichia coli.
Journal
Environmental microbiology reports
ISSN: 1758-2229
Titre abrégé: Environ Microbiol Rep
Pays: United States
ID NLM: 101499207
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
21
04
2023
accepted:
05
05
2023
medline:
4
9
2023
pubmed:
17
5
2023
entrez:
17
5
2023
Statut:
ppublish
Résumé
The consumption of coffee and other caffeinated drinks is increasingly popular across the globe. In the United States, 90% of adults consume at least one caffeinated beverage a day. While caffeine consumption of up to 400 mg/d is not generally associated with negative effects on human health, the impact of caffeine on the gut microbiome and individual gut microbiota remains unclear. We examined the effect of caffeine on the growth rate of Escherichia coli, a bacterium commonly found in the human gut, when grown aerobically or anaerobically in nutrient-rich or minimal medium. A significant negative correlation was observed between caffeine concentration and growth rate under all conditions, suggesting that caffeine can act as an antimicrobial agent when ingested. Caffeine reduced growth rates significantly more in nutrient-poor, but not in anoxic, conditions. Given the highly variable nutrient and oxygen conditions of the gut, these results suggest a need to further explore caffeine's inhibitory effects on the gut microbiome and its relation to human health.
Identifiants
pubmed: 37194345
doi: 10.1111/1758-2229.13165
pmc: PMC10472513
doi:
Substances chimiques
Caffeine
3G6A5W338E
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-425Informations de copyright
© 2023 The Authors. Environmental Microbiology Reports published by Applied Microbiology International and John Wiley & Sons Ltd.
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