Stimulation to probe, excite, and inhibit the epileptic brain.
deep brain stimulation
diagnosis
electrical stimulation
epilepsy
treatment
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
17 May 2023
17 May 2023
Historique:
revised:
01
05
2023
received:
13
01
2023
accepted:
02
05
2023
pmc-release:
17
11
2024
pubmed:
17
5
2023
medline:
17
5
2023
entrez:
17
5
2023
Statut:
aheadofprint
Résumé
Direct cortical stimulation has been applied in epilepsy for nearly a century and has experienced a renaissance, given unprecedented opportunities to probe, excite, and inhibit the human brain. Evidence suggests stimulation can increase diagnostic and therapeutic utility in patients with drug-resistant epilepsies. However, choosing appropriate stimulation parameters is not a trivial issue, and is further complicated by epilepsy being characterized by complex brain state dynamics. In this article derived from discussions at the ICTALS 2022 Conference (International Conference on Technology and Analysis for Seizures), we succinctly review the literature on cortical stimulation applied acutely and chronically to the epileptic brain for localization, monitoring, and therapeutic purposes. In particular, we discuss how stimulation is used to probe brain excitability, discuss evidence on the usefulness of stimulation to trigger and stop seizures, review therapeutic applications of stimulation, and finally discuss how stimulation parameters are impacted by brain dynamics. Although research has advanced considerably over the past decade, there are still significant hurdles to optimizing use of this technique. For example, it remains unclear to what extent short timescale diagnostic biomarkers can predict long-term outcomes and to what extent these biomarkers add information to already existing biomarkers from passive electroencephalographic recordings. Further questions include the extent to which closed loop stimulation offers advantages over open loop stimulation, what the optimal closed loop timescales may be, and whether biomarker-informed stimulation can lead to seizure freedom. The ultimate goal of bioelectronic medicine remains not just to stop seizures but rather to cure epilepsy and its comorbidities.
Identifiants
pubmed: 37194746
doi: 10.1111/epi.17640
pmc: PMC10654261
mid: NIHMS1901808
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : K23 NS112339
Pays : United States
Organisme : NINDS NIH HHS
ID : K23NS112339
Pays : United States
Organisme : CIHR
ID : PJT-175056
Pays : Canada
Informations de copyright
© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
Références
Ann Neurol. 2022 Jul;92(1):61-74
pubmed: 35429045
J Neurol Neurosurg Psychiatry. 2020 Oct 28;:
pubmed: 33115935
Clin Neurophysiol. 2020 Dec;131(12):2781-2792
pubmed: 33130438
Neurophysiol Clin. 2018 Feb;48(1):5-13
pubmed: 29277357
Epilepsy Res. 2021 Oct;176:106702
pubmed: 34229226
Neurology. 2011 Sep 27;77(13):1295-304
pubmed: 21917777
Lancet Neurol. 2021 Dec;20(12):1038-1047
pubmed: 34710360
Front Neuroinform. 2019 Apr 24;13:31
pubmed: 31068798
Seizure. 2020 Oct;81:304-309
pubmed: 32947179
PLoS Comput Biol. 2020 Nov 9;16(11):e1008430
pubmed: 33166277
Clin Neurophysiol. 2012 Feb;123(2):252-60
pubmed: 21802356
Brain. 2018 Sep 1;141(9):2631-2643
pubmed: 29985998
JAMA Neurol. 2019 Sep 01;76(9):1070-1078
pubmed: 31180505
Brain. 2001 Sep;124(Pt 9):1683-700
pubmed: 11522572
Acta Neurochir Suppl (Wien). 1993;58:181-5
pubmed: 8109287
J Anat. 2019 Sep;235(3):507-520
pubmed: 30657169
Clin Neurol Neurosurg. 2022 Mar;214:107170
pubmed: 35219180
Clin Neurophysiol. 2020 Nov;131(11):2657-2666
pubmed: 32957038
Epilepsy Behav. 2022 Dec;137(Pt A):108951
pubmed: 36327647
Neurology. 2013 Nov 19;81(21):1869-76
pubmed: 24142476
Epilepsy Res. 2018 Feb;140:171-176
pubmed: 29367180
Brain Stimul. 2019 Jul - Aug;12(4):877-892
pubmed: 30904423
Epilepsia. 2008 Oct;49(10):1651-64
pubmed: 18503563
Clin Neurophysiol. 2016 Jan;127(1):31-39
pubmed: 25613034
Brain. 2010 Sep;133(9):2789-97
pubmed: 20685804
Brain. 2000 Aug;123 ( Pt 8):1733-51
pubmed: 10908202
Clin Neurophysiol. 2016 Feb;127(2):1088-1098
pubmed: 26377063
Epilepsia. 2017 Jul;58(7):1131-1147
pubmed: 28543030
Clin Neurophysiol. 2013 Jul;124(7):1290-6
pubmed: 23523110
Clin Neurophysiol. 2023 Jan;145:119-128
pubmed: 36127246
Epilepsia. 2022 Oct;63(10):2445-2460
pubmed: 35700144
Epilepsia. 2013 Oct;54(10):1823-33
pubmed: 24032641
Brain Connect. 2022 Dec;12(10):850-869
pubmed: 35972755
J Physiol. 2013 Feb 15;591(4):787-97
pubmed: 23184516
Epilepsia. 2018 Jan;59(1):16-26
pubmed: 29143307
Front Neurol. 2015 Sep 01;6:192
pubmed: 26388834
Brain. 2022 Nov 21;145(11):3886-3900
pubmed: 35703986
Brain. 2006 Jul;129(Pt 7):1917-28
pubmed: 16760199
Trends Neurosci. 2004 Sep;27(9):520-7
pubmed: 15331233
Seizure. 2020 Oct;81:276-279
pubmed: 32919252
Epilepsia. 2016 Jan;57(1):131-40
pubmed: 26647755
Brain Stimul. 2021 Mar-Apr;14(2):366-375
pubmed: 33556620
Chaos. 2019 Sep;29(9):091104
pubmed: 31575122
Epilepsia Open. 2021 Sep;6(3):611-617
pubmed: 34268893
Neurology. 2021 Jan 12;96(2):e280-e293
pubmed: 33024023
Nat Commun. 2020 May 1;11(1):2172
pubmed: 32358560
Hum Brain Mapp. 2021 Sep;42(13):4173-4186
pubmed: 34165233
Clin Neurophysiol. 2016 Jan;127(1):91-101
pubmed: 25910851
Brain. 2002 Aug;125(Pt 8):1709-18
pubmed: 12135963
Brain. 2011 Oct;134(Pt 10):2855-66
pubmed: 21900209
Neuroscience. 2004;123(2):299-336
pubmed: 14698741
Brain Stimul. 2016 Mar-Apr;9(2):268-75
pubmed: 26680105
Epilepsia. 2019 Apr;60(4):e25-e30
pubmed: 30767195
Sci Transl Med. 2021 Aug 25;13(608):
pubmed: 34433640
Epilepsia. 2021 Jun;62(6):1306-1317
pubmed: 33830503
Neurology. 1999 Dec 10;53(9):2073-81
pubmed: 10599784
Front Neurol. 2020 Dec 10;11:579961
pubmed: 33362689
Epilepsy Behav. 2021 Aug;121(Pt B):106591
pubmed: 31806490
Epilepsia. 2023 Feb;64(2):e16-e22
pubmed: 36385467
Brain Commun. 2019;1(1):fcz010
pubmed: 31667473
Brain. 2021 Apr 12;144(3):885-908
pubmed: 33501929
Epilepsia. 2023 Jun;64(6):e118-e126
pubmed: 36994648
J Clin Neurophysiol. 2021 Nov 1;38(6):485-493
pubmed: 34261113
Brain. 2021 Dec 16;144(11):3340-3354
pubmed: 34849596
Brain. 2007 Jan;130(Pt 1):181-97
pubmed: 17046857
Seizure. 2017 Jan;44:27-36
pubmed: 27939100
Clin Neurophysiol. 2004 Nov;115(11):2431-41
pubmed: 15465430
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2524-2527
pubmed: 33018520
Ann Neurol. 2022 Feb;91(2):253-267
pubmed: 34877694
Electroencephalogr Clin Neurophysiol. 1990 May;75(5):371-7
pubmed: 1692272
Neurosurgery. 2016 Sep;79(3):345-53
pubmed: 26645965
Epileptic Disord. 2010 Dec;12(4):292-302
pubmed: 20952353
J Neurosurg. 2022 Sep 23;138(4):1002-1007
pubmed: 36152321
J Clin Neurophysiol. 2016 Dec;33(6):511-521
pubmed: 27918346
Lancet Neurol. 2005 Nov;4(11):718-26
pubmed: 16239178
Brain Stimul. 2020 Sep - Oct;13(5):1232-1244
pubmed: 32504827
Seizure. 2020 Oct;81:201-209
pubmed: 32861153
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21116-21
pubmed: 23213262
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2528-2531
pubmed: 33018521
Brain. 2022 Oct 21;145(10):3347-3362
pubmed: 35771657
Brain Commun. 2022 Jul 06;4(4):fcac173
pubmed: 35855481
Clin Neurophysiol. 2017 May;128(5):858-866
pubmed: 28258937
Brain. 2004 Oct;127(Pt 10):2316-30
pubmed: 15269116
Epilepsia. 2006 Jan;47(1):98-107
pubmed: 16417537
Brain Stimul. 2021 Mar-Apr;14(2):344-346
pubmed: 33548488
Clin Neurophysiol. 2019 Aug;130(8):1364-1374
pubmed: 31212202
Brain Stimul. 2022 Mar-Apr;15(2):491-508
pubmed: 35247646
Elife. 2020 Jul 21;9:
pubmed: 32691734
Neuroimage. 2018 Nov 1;181:414-429
pubmed: 30025851
Neurology. 2020 Sep 1;95(9):e1244-e1256
pubmed: 32690786
Front Hum Neurosci. 2020 Dec 07;14:611291
pubmed: 33364930
Trends Neurosci. 1997 Oct;20(10):443-8
pubmed: 9347609
Epilepsia. 2010 May;51(5):899-908
pubmed: 20331461