Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury.

chronic disease joint structural changes knee arthroplasty knee injury osteoarthritis risk factors symptoms

Journal

Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140

Informations de publication

Date de publication:
2023
Historique:
received: 21 10 2022
accepted: 28 03 2023
pubmed: 18 5 2023
medline: 18 5 2023
entrez: 17 5 2023
Statut: epublish

Résumé

For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the need for knee arthroplasty. To explore, in an older adult population, how nonsurgical knee injuries relate to osteoarthritis incidence/progression and the weight of independent risk factors for arthroplasty. A cohort study design evaluates the long-term impact of injuries on knee osteoarthritis outcomes. Knees with no prior injury ( At inclusion, knees with prior injury demonstrated greater incidence and severity of osteoarthritis ( This study highlights the importance of nonsurgical knee injury in older adults as an independent risk factor for knee osteoarthritis and arthroplasty. These data will be beneficial in clinical practice as they will help identify individuals at greater risk of significant disease progression and worst disease outcomes for a customized therapeutic approach.

Sections du résumé

Background UNASSIGNED
For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the need for knee arthroplasty.
Objectives UNASSIGNED
To explore, in an older adult population, how nonsurgical knee injuries relate to osteoarthritis incidence/progression and the weight of independent risk factors for arthroplasty.
Design UNASSIGNED
A cohort study design evaluates the long-term impact of injuries on knee osteoarthritis outcomes.
Methods UNASSIGNED
Knees with no prior injury (
Results UNASSIGNED
At inclusion, knees with prior injury demonstrated greater incidence and severity of osteoarthritis (
Conclusion UNASSIGNED
This study highlights the importance of nonsurgical knee injury in older adults as an independent risk factor for knee osteoarthritis and arthroplasty. These data will be beneficial in clinical practice as they will help identify individuals at greater risk of significant disease progression and worst disease outcomes for a customized therapeutic approach.

Identifiants

pubmed: 37197137
doi: 10.1177/20406223231169715
pii: 10.1177_20406223231169715
pmc: PMC10184209
doi:

Types de publication

Journal Article

Langues

eng

Pagination

20406223231169715

Informations de copyright

© The Author(s), 2023.

Déclaration de conflit d'intérêts

The authors declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: J.-P.P. and J.M.-P. are shareholders in ArthroLab Inc.

Auteurs

Jean-Pierre Pelletier (JP)

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Room R11.412A, Montreal, QC H2X 0A9, Canada.

Patrice Paiement (P)

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.

Marc Dorais (M)

StatSciences Inc., Notre-Dame-de-l'Île-Perrot, QC, Canada.

Jean-Pierre Raynauld (JP)

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.

Johanne Martel-Pelletier (J)

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.

Classifications MeSH