Cell-Based Therapies for Degenerative Musculoskeletal Diseases.
cell-based therapies
degenerative musculoskeletal diseases
exosomes
extracellular vesicles
stem cells
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
29
04
2023
received:
30
11
2022
medline:
31
7
2023
pubmed:
18
5
2023
entrez:
18
5
2023
Statut:
ppublish
Résumé
Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis, degenerative disc disease, and sarcopenia, present major challenges in the aging population. Patients with DMDs present with pain, functional decline, and reduced exercise tolerance, which result in long-term or permanent deficits in their ability to perform daily activities. Current strategies for dealing with this cluster of diseases focus on relieving pain, but they have a limited capacity to repair function or regenerate tissue. Cell-based therapies have attracted considerable attention in recent years owing to their unique mechanisms of action and remarkable effects on regeneration. In this review, current experimental attempts to use cell-based therapies for DMDs are highlighted, and the modes of action of different cell types and their derivatives, such as exosomes, are generalized. In addition, the latest findings from state-of-the-art clinical trials are reviewed, approaches to improve the efficiency of cell-based therapies are summarized, and unresolved questions and potential future research directions for the translation of cell-based therapies are identified.
Identifiants
pubmed: 37199688
doi: 10.1002/advs.202207050
pmc: PMC10375105
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2207050Subventions
Organisme : National Natural Science Foundation of China
ID : 81972102
Organisme : National Natural Science Foundation of China
ID : 82002330
Organisme : National Natural Science Foundation of China
ID : 81972115
Organisme : National Key Research and Development Program of China
ID : 2019YFC0840705
Organisme : Young Elite Scientist Sponsorship Program by the China Association for Science and Technology
ID : 2020-JCJQ-QT-033
Organisme : Training Program of the National Science Fund for Distinguished Young Scholars
ID : 2020-JQPY-003
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
Nat Mater. 2014 Oct;13(10):979-87
pubmed: 25108614
Biofabrication. 2022 Dec 15;15(1):
pubmed: 36541475
J Nutr Health Aging. 2018;22(10):1148-1161
pubmed: 30498820
Nat Biomed Eng. 2021 Nov;5(11):1246-1260
pubmed: 34083764
Stem Cell Rev Rep. 2017 Apr;13(2):299-308
pubmed: 27987073
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Am J Sports Med. 2012 Oct;40(10):2273-80
pubmed: 22922521
Adv Sci (Weinh). 2023 Jul;10(21):e2207050
pubmed: 37199688
Clin Orthop Relat Res. 2014 Jan;472(1):41-51
pubmed: 23979923
Nature. 2021 Sep;597(7875):256-262
pubmed: 34381212
Arch Osteoporos. 2022 Jan 26;17(1):23
pubmed: 35079919
PLoS One. 2015 Apr 20;10(4):e0124774
pubmed: 25894203
Free Radic Biol Med. 2019 Nov 1;143:1-15
pubmed: 31351174
Sci Rep. 2018 Feb 20;8(1):3330
pubmed: 29463809
Stem Cells. 2009 May;27(5):1050-6
pubmed: 19415771
J Oral Sci. 2019 Mar 28;61(1):30-35
pubmed: 30541990
Cell Stem Cell. 2010 Jul 2;7(1):20-4
pubmed: 20621045
Nat Rev Drug Discov. 2020 Mar;19(3):185-199
pubmed: 31900462
IUBMB Life. 2018 Jun;70(6):479-490
pubmed: 29707878
Stem Cell Reports. 2015 Sep 8;5(3):419-34
pubmed: 26352798
J Cell Physiol. 2009 Feb;218(2):237-45
pubmed: 18792913
Stem Cells Int. 2019 Sep 9;2019:7132708
pubmed: 31582986
J Orthop Translat. 2020 Mar 03;26:171-180
pubmed: 33437636
Nat Rev Rheumatol. 2015 Jan;11(1):21-34
pubmed: 25247412
J Orthop Translat. 2020 Apr 30;23:38-52
pubmed: 32489859
Adv Mater. 2020 Apr;32(13):e1902005
pubmed: 31495970
Front Mol Biosci. 2020 Mar 06;7:33
pubmed: 32211418
Spine J. 2021 Feb;21(2):212-230
pubmed: 33045417
Bioact Mater. 2021 Feb 23;6(9):2905-2913
pubmed: 33718671
Lancet Diabetes Endocrinol. 2017 Nov;5(11):898-907
pubmed: 28689769
Lancet. 2019 Apr 27;393(10182):1745-1759
pubmed: 31034380
Biomaterials. 2019 Jun;206:87-100
pubmed: 30927715
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
J Transl Med. 2018 Jul 31;16(1):213
pubmed: 30064455
Stem Cells. 2009 Aug;27(8):1802-11
pubmed: 19544436
Stem Cells Int. 2018 Mar 25;2018:8490489
pubmed: 29765426
Nano Lett. 2019 May 8;19(5):3040-3048
pubmed: 30968694
Cell Prolif. 2010 Jun;43(3):235-48
pubmed: 20546242
Curr Opin Biotechnol. 2014 Feb;25:95-102
pubmed: 24484886
Nano Lett. 2015 Jul 8;15(7):4720-9
pubmed: 26027605
J Bone Joint Surg Am. 2013 Oct 16;95(20):1885-6
pubmed: 24288804
Science. 1998 Nov 6;282(5391):1145-7
pubmed: 9804556
Stem Cells Transl Med. 2017 Jun;6(6):1445-1451
pubmed: 28452204
Nanomedicine (Lond). 2019 Dec;14(24):3193-3212
pubmed: 31855117
FEBS Lett. 2016 Jan;590(1):185-92
pubmed: 26763102
Br Med Bull. 2013;105:185-99
pubmed: 23337796
N Engl J Med. 2020 Aug 20;383(8):743-753
pubmed: 32813950
Nat Biotechnol. 2018 Sep;36(8):717-725
pubmed: 29985478
Cell. 2018 Sep 20;175(1):43-56.e21
pubmed: 30241615
Biomed Mater Eng. 2010;20(3):145-58
pubmed: 20930322
Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):324-8
pubmed: 24848532
Biomedicines. 2021 Feb 12;9(2):
pubmed: 33673154
Stem Cells Transl Med. 2019 Aug;8(8):746-757
pubmed: 30964245
Stem Cell Res Ther. 2017 Aug 14;8(1):189
pubmed: 28807034
J Bone Miner Res. 2014 Feb;29(2):338-47
pubmed: 23821519
JAMA. 2014 Feb 12;311(6):617-8
pubmed: 24519302
Small. 2019 Jun;15(24):e1805530
pubmed: 31012262
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):419-27
pubmed: 19926330
Gut. 2015 Jul;64(7):1072-81
pubmed: 25298539
PLoS One. 2012;7(3):e33739
pubmed: 22438989
Stem Cell Reports. 2015 Mar 10;4(3):404-18
pubmed: 25733017
J Cell Mol Med. 2020 Oct;24(20):11742-11754
pubmed: 32860495
J Cereb Blood Flow Metab. 2018 Aug;38(8):1276-1292
pubmed: 29768965
Nat Rev Rheumatol. 2015 Apr;11(4):243-56
pubmed: 25708497
Cell Biosci. 2022 May 19;12(1):66
pubmed: 35590379
Nat Biotechnol. 2008 Nov;26(11):1276-84
pubmed: 18931654
Curr Opin Biotechnol. 2015 Dec;35:118-26
pubmed: 26094109
Int J Mol Sci. 2015 Mar 11;16(3):5517-27
pubmed: 25768338
Stem Cells Transl Med. 2019 Mar;8(3):215-224
pubmed: 30592390
Stem Cells Int. 2021 Feb 4;2021:8884283
pubmed: 33628275
J Cell Mol Med. 2017 May;21(5):1033-1041
pubmed: 27878944
Adv Funct Mater. 2017 Jul 26;27(28):
pubmed: 33041740
Arch Iran Med. 2012 Aug;15(8):495-9
pubmed: 22827787
Transplantation. 2017 Aug;101(8):1945-1951
pubmed: 27661661
Nat Med. 2012 Feb 05;18(3):456-62
pubmed: 22306732
Oncotarget. 2017 Oct 4;8(51):88845-88856
pubmed: 29179481
Cell Transplant. 2013;22(8):1395-408
pubmed: 22889498
Dev Growth Differ. 2021 Jan;63(1):72-81
pubmed: 33411345
Trends Mol Med. 2008 Feb;14(2):82-91
pubmed: 18218339
Cell. 2003 Oct 31;115(3):281-92
pubmed: 14636556
JAMA. 2019 Mar 12;321(10):969-982
pubmed: 30860559
Lancet. 2019 Jun 29;393(10191):2636-2646
pubmed: 31171417
Osteoporos Int. 2011 Jan;22(1):1-20
pubmed: 20458572
Cell. 2005 Jul 29;122(2):289-301
pubmed: 16051152
Bone Res. 2020 Jun 19;8:25
pubmed: 32596023
Cell Prolif. 2020 Jul;53(7):e12857
pubmed: 32578911
Front Immunol. 2019 Jun 05;10:1246
pubmed: 31231381
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Spine (Phila Pa 1976). 2013 Jan 1;38(1):24-36
pubmed: 22996268
J Adv Res. 2017 Jul;8(4):321-327
pubmed: 28386481
Nat Rev Drug Discov. 2017 Feb;16(2):115-130
pubmed: 27980341
Nat Mater. 2015 Dec;14(12):1269-77
pubmed: 26366848
J Neuroinflammation. 2019 Sep 12;16(1):178
pubmed: 31514749
Adv Drug Deliv Rev. 2020;159:332-343
pubmed: 32305351
Nature. 2018 Apr 5;556(7699):57-63
pubmed: 29512652
Biochem Biophys Res Commun. 2020 Mar 5;523(2):506-513
pubmed: 31898972
Restor Neurol Neurosci. 2010;28(4):589-603
pubmed: 20714081
PLoS One. 2008 Apr 02;3(4):e1886
pubmed: 18382669
Theranostics. 2017 Jan 1;7(1):180-195
pubmed: 28042326
Biomaterials. 2008 Oct;29(29):3973-82
pubmed: 18639333
Nat Rev Clin Oncol. 2023 Jan;20(1):49-62
pubmed: 36418477
Stem Cell Res Ther. 2022 Jan 24;13(1):28
pubmed: 35073997
Biotechnol Lett. 2016 Feb;38(2):203-11
pubmed: 26466597
Lancet. 2019 Jan 26;393(10169):364-376
pubmed: 30696576
Cell. 2015 Jan 15;160(1-2):285-98
pubmed: 25594184
Exp Cell Res. 2018 Feb 1;363(1):114-120
pubmed: 29277503
Am J Physiol Renal Physiol. 2005 Jul;289(1):F31-42
pubmed: 15713913
Cell Mol Life Sci. 2015 May;72(9):1663-77
pubmed: 25572293
Cytotherapy. 2018 Oct;20(10):1238-1246
pubmed: 30318332
Cell Stem Cell. 2020 Oct 1;27(4):523-531
pubmed: 33007237
Nat Biotechnol. 2019 Mar;37(3):252-258
pubmed: 30778232
Differentiation. 2010 Jul;80(1):9-19
pubmed: 20537458
Science. 2013 Aug 9;341(6146):651-4
pubmed: 23868920
Stem Cells. 2021 Apr;39(4):467-481
pubmed: 33459443
Arthritis Res Ther. 2010;12(6):R206
pubmed: 21054867
Biomaterials. 2012 Jun;33(19):4792-800
pubmed: 22483246
Cell Stem Cell. 2008 Sep 11;3(3):340-5
pubmed: 18786420
Biotechnol Adv. 2019 Dec;37(8):107447
pubmed: 31513841
Injury. 2013 Apr;44(4):540-9
pubmed: 23337703
Immunol Res. 2016 Aug;64(4):831-40
pubmed: 27115513
Sci Adv. 2019 Nov 20;5(11):eaaw7215
pubmed: 31799389
Cytotherapy. 2019 Jan;21(1):54-63
pubmed: 30522806
Stem Cells. 2015 Jan;33(1):146-56
pubmed: 25187512
J Cell Physiol. 2011 Jan;226(1):150-7
pubmed: 20658533
Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R351-8
pubmed: 23697797
FASEB J. 2006 Apr;20(6):661-9
pubmed: 16581974
Stem Cell Res Ther. 2019 Feb 22;10(1):63
pubmed: 30795797
Cells. 2021 Aug 29;10(9):
pubmed: 34571890
Stem Cell Res Ther. 2021 May 13;12(1):286
pubmed: 33985571
J Cell Biochem. 1997 Feb;64(2):295-312
pubmed: 9027589
Cell Cycle. 2020 Jul;19(14):1727-1739
pubmed: 32635856
J Neurosurg Spine. 2019 Jul 1;31(1):1-14
pubmed: 31261133
Bioact Mater. 2021 Sep 17;10:207-221
pubmed: 34901540
Exp Physiol. 2019 Aug;104(8):1262-1273
pubmed: 31115069
FEBS Lett. 2015 May 8;589(11):1257-65
pubmed: 25862500
Biomaterials. 2013 Sep;34(28):6580-8
pubmed: 23787112
Biochem Biophys Res Commun. 2021 Dec 10;582:64-71
pubmed: 34689107
J Vis Exp. 2017 Jun 19;(124):
pubmed: 28654049
Stem Cells Transl Med. 2019 Jun;8(6):504-511
pubmed: 30835956
J Cell Mol Med. 2004 Jul-Sep;8(3):301-16
pubmed: 15491506
PLoS One. 2013 Sep 18;8(9):e75227
pubmed: 24058665
Regen Med. 2019 Mar;14(3):213-230
pubmed: 30762487
Front Bioeng Biotechnol. 2020 Oct 23;8:594247
pubmed: 33195163
Stem Cell Res Ther. 2015 May 29;6:111
pubmed: 26021377
Arthritis Rheum. 2003 Dec;48(12):3464-74
pubmed: 14673997
Nature. 2022 May;605(7909):325-331
pubmed: 35418683
Sci Rep. 2016 Feb 25;6:21961
pubmed: 26911789
Stem Cell Res. 2007 Nov;1(2):129-37
pubmed: 19383393
J Control Release. 2016 Jan 28;222:107-15
pubmed: 26699421
J Extracell Vesicles. 2014 Feb 19;3:
pubmed: 24563732
Cell Stem Cell. 2022 Nov 3;29(11):1515-1530
pubmed: 36332569
Nat Commun. 2016 Mar 07;7:10872
pubmed: 26947250
Signal Transduct Target Ther. 2021 Feb 16;6(1):65
pubmed: 33589598
Ann Intern Med. 2020 Oct 6;173(7):516-526
pubmed: 32716706
Nat Commun. 2018 Feb 23;9(1):800
pubmed: 29476074
J Bone Joint Surg Br. 2005 May;87(5):640-5
pubmed: 15855365
Cell Stem Cell. 2021 Oct 7;28(10):1708-1725
pubmed: 34624232
Biomaterials. 2008 Jan;29(1):85-93
pubmed: 17920676
Osteoporos Int. 2013 Jan;24(1):253-62
pubmed: 23100120
Nature. 2020 Jan;577(7790):405-409
pubmed: 31775156
Oncotarget. 2017 Jun 27;8(26):42700-42711
pubmed: 28498811
Nat Rev Drug Discov. 2021 Jul;20(7):531-550
pubmed: 33972771
J Clin Endocrinol Metab. 2019 May 1;104(5):1623-1630
pubmed: 30907957
Biomicrofluidics. 2013 Oct 29;7(5):51502
pubmed: 24273628
Br Med Bull. 2013;108:25-53
pubmed: 24152971
Spine (Phila Pa 1976). 2003 Mar 15;28(6):548-53
pubmed: 12642760
Stem Cells Int. 2019 May 6;2019:8404168
pubmed: 31249601
Int Orthop. 2021 Feb;45(2):365-373
pubmed: 32322943
Nat Protoc. 2012 Dec;7(12):2080-9
pubmed: 23138349
J Transl Med. 2012 May 21;10:102
pubmed: 22613677
Nat Rev Genet. 2019 Jul;20(7):377-388
pubmed: 30737492
Diabetologia. 2014 Oct;57(10):2155-64
pubmed: 25073444
Arthroscopy. 2013 Jan;29(1):89-97
pubmed: 23142295
Colloids Surf B Biointerfaces. 2017 Nov 1;159:62-77
pubmed: 28780462
Int J Nanomedicine. 2014 May 07;9 Suppl 1:141-57
pubmed: 24872709
J Cell Physiol. 2020 Dec;235(12):9763-9772
pubmed: 32424865
Med Biol Eng Comput. 2003 May;41(3):365-71
pubmed: 12803304
Mol Pathol. 2002 Apr;55(2):91-7
pubmed: 11950957
Eur Cell Mater. 2015 Mar 20;29:202-12; discussion 212
pubmed: 25794529
Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110264
pubmed: 31761183
Front Cell Dev Biol. 2017 Mar 07;5:17
pubmed: 28326305
Biomaterials. 2018 Aug;174:67-78
pubmed: 29783118
Cells. 2022 Mar 15;11(6):
pubmed: 35326446
Int J Biol Sci. 2016 May 25;12(7):836-49
pubmed: 27313497
Stem Cell Res Ther. 2016 Nov 10;7(1):160
pubmed: 27832815
Stem Cell Res Ther. 2018 Sep 26;9(1):247
pubmed: 30257711
Pathol Res Pract. 2019 Sep;215(9):152519
pubmed: 31272760
Chin Med J (Engl). 2020 Aug 26;134(2):212-218
pubmed: 32858593
Cell Stem Cell. 2010 Jul 2;7(1):15-9
pubmed: 20621044