Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
Bacterial infections
Immunology
Infectious disease
Innate immunity
Tuberculosis
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
15 06 2023
15 06 2023
Historique:
received:
19
01
2022
accepted:
19
04
2023
medline:
16
6
2023
pubmed:
18
5
2023
entrez:
18
5
2023
Statut:
epublish
Résumé
The ADP ribosyltransferases (PARPs 1-17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). Although PARP9 mRNA expression is significantly increased in progressive tuberculosis (TB) in humans, its participation in host immunity to TB is unknown. Here, we show that PARP9 mRNA encoding the MARylating PARP9 enzyme was upregulated during TB in humans and mice and provide evidence of a critical modulatory role for PARP9 in DNA damage, cyclic GMP-AMP synthase (cGAS) expression, and type I IFN production during TB. Thus, Parp9-deficient mice were susceptible to Mycobacterium tuberculosis infection and exhibited increased TB disease, cGAS and 2'3'-cyclic GMP-AMP (cGAMP) expression, and type I IFN production, along with upregulation of complement and coagulation pathways. Enhanced M. tuberculosis susceptibility is type I IFN dependent, as blockade of IFN α receptor (IFNAR) signaling reversed the enhanced susceptibility of Parp9-/- mice. Thus, in sharp contrast to PARP9 enhancement of type I IFN production in viral infections, this member of the MAR family plays a protective role by limiting type I IFN responses during TB.
Identifiants
pubmed: 37200107
pii: 158630
doi: 10.1172/JCI158630
pmc: PMC10266794
doi:
pii:
Substances chimiques
Nucleotidyltransferases
EC 2.7.7.-
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
PARP9 protein, human
0
Parp9 protein, mouse
EC 2.4.2.30
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI111914
Pays : United States
Références
PLoS Med. 2019 Apr 16;16(4):e1002781
pubmed: 30990820
Nat Commun. 2016 Oct 31;7:12849
pubmed: 27796300
Front Immunol. 2019 Mar 04;10:362
pubmed: 30886620
Mol Cell. 2017 May 18;66(4):503-516.e5
pubmed: 28525742
Blood. 2020 Mar 26;135(13):1049-1057
pubmed: 31932840
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14490-5
pubmed: 19706534
PLoS One. 2017 Feb 3;12(2):e0171582
pubmed: 28158293
Nat Commun. 2021 May 11;12(1):2681
pubmed: 33976210
Genes Dev. 2021 May 1;35(9-10):602-618
pubmed: 33888558
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Elife. 2020 Mar 30;9:
pubmed: 32223892
Mucosal Immunol. 2017 Jul;10(4):1069-1081
pubmed: 28247861
Biochem Soc Trans. 2000 Oct;28(5):545-50
pubmed: 11044372
J Infect Dis. 2018 Mar 28;217(8):1318-1322
pubmed: 29325117
J Biol Chem. 2021 Sep;297(3):101041
pubmed: 34358560
J Pharmacol Toxicol Methods. 1996 Apr;35(2):101-5
pubmed: 8729436
J Nucleic Acids. 2010 Aug 03;2010:
pubmed: 20811597
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Cell Mol Immunol. 2017 Jan;14(1):22-35
pubmed: 27264686
Nucleic Acids Res. 2017 Jul 3;45(W1):W130-W137
pubmed: 28472511
J Immunol. 2014 Oct 1;193(7):3600-12
pubmed: 25187652
Mol Cell Biol. 2006 Jul;26(14):5348-59
pubmed: 16809771
Jpn J Infect Dis. 2013;66(6):480-8
pubmed: 24270134
Int J Mol Sci. 2020 Apr 30;21(9):
pubmed: 32365959
Mol Cell Biol. 2013 Feb;33(4):845-57
pubmed: 23230272
FEBS J. 2022 Dec;289(23):7399-7410
pubmed: 34323016
Eur J Immunol. 2017 Apr;47(4):665-676
pubmed: 28105679
Nucleic Acids Res. 2021 Jan 8;49(D1):D884-D891
pubmed: 33137190
J Exp Med. 1977 Sep 1;146(3):673-89
pubmed: 302303
Nucleic Acids Res. 2020 Jan 8;48(D1):D682-D688
pubmed: 31691826
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46
pubmed: 24047412
Semin Nephrol. 2013 Nov;33(6):479-92
pubmed: 24161035
Annu Rev Immunol. 2005;23:821-52
pubmed: 15771587
Nucleic Acids Res. 2021 Jan 8;49(D1):D325-D334
pubmed: 33290552
Genome Biol. 2010;11(10):R106
pubmed: 20979621
PLoS Pathog. 2017 Nov 16;13(11):e1006687
pubmed: 29145483
Nucleic Acids Res. 2011 Jan;39(Database issue):D19-21
pubmed: 21062823
Thromb Haemost. 1982 Aug 24;48(1):108-11
pubmed: 6753230
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
Respiration. 2021;100(7):553-556
pubmed: 34034257
Immunity. 2011 Dec 23;35(6):1023-34
pubmed: 22195750
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
J Clin Invest. 2020 Apr 1;130(4):1912-1930
pubmed: 31917687
Lancet. 2016 Jun 4;387(10035):2312-2322
pubmed: 27017310
Nat Immunol. 2007 Apr;8(4):369-77
pubmed: 17351619
Nat Immunol. 2020 Apr;21(4):464-476
pubmed: 32205882
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
Nat Immunol. 2015 Dec;16(12):1215-27
pubmed: 26479788
Nat Microbiol. 2018 Oct;3(10):1099-1108
pubmed: 30224802
Front Immunol. 2018 Jul 26;9:1731
pubmed: 30105021
Euro Surveill. 2016 Aug 25;21(34):
pubmed: 27589214
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11
pubmed: 24672678
Front Immunol. 2017 Apr 05;8:294
pubmed: 28424682
Sci Transl Med. 2020 Jan 29;12(528):
pubmed: 31996462