A Case of Paradoxical Arthralgia Following Anti-TNF Monoclonal Antibody Administration in a Patient With New-Onset Pediatric Crohn's Disease.
adverse event
arthralgia
azathioprine
infliximab
paradoxical reaction
Journal
JPGN reports
ISSN: 2691-171X
Titre abrégé: JPGN Rep
Pays: United States
ID NLM: 101773885
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
29
08
2022
accepted:
22
03
2023
medline:
18
5
2023
pubmed:
18
5
2023
entrez:
18
5
2023
Statut:
epublish
Résumé
Anti-TNF antibodies have become a first-line therapy in moderate-to-severe inflammatory bowel diseases. However, there may be some rare paradoxical events and those affecting joints causing severe symptoms need a scrupulous differential diagnosis. When these events occur, it may be necessary to discontinue treatment and shift to another drug class. Herein, we report the case of a 15-year-old boy affected by Crohn's disease, who developed a paradoxical reaction after the second dose of infliximab. Clinical remission was achieved shifting to budesonide and azathioprine and continuing maintenance therapy with azathioprine alone. To date, no other paradoxical events have occurred.
Identifiants
pubmed: 37200710
doi: 10.1097/PG9.0000000000000308
pmc: PMC10187859
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e308Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
J Crohns Colitis. 2020 Oct 07;:
pubmed: 33026087
J Crohns Colitis. 2015 Sep;9(9):806-15
pubmed: 26092578
Aliment Pharmacol Ther. 2011 Dec;34(11-12):1318-27
pubmed: 21957906
Curr Mol Pharmacol. 2010 Nov;3(3):145-52
pubmed: 20799925
Nat Rev Gastroenterol Hepatol. 2012 Sep;9(9):496-503
pubmed: 22751454
Gastroenterology. 2003 Jul;125(1):32-9
pubmed: 12851868
Minerva Gastroenterol Dietol. 2010 Jun;56(2):233-43
pubmed: 20485259
Clin Pharmacol Ther. 1981 Aug;30(2):239-45
pubmed: 7249508
Clin Gastroenterol Hepatol. 2010 Dec;8(12):1048-55
pubmed: 20728573
J Crohns Colitis. 2015 Nov;9(11):982-7
pubmed: 26351388