Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
29
8
2023
pubmed:
19
5
2023
entrez:
18
5
2023
Statut:
ppublish
Résumé
Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function. We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin deficiency and 50 healthy controls. Fibrin clot permeability (K Antithrombin-deficient patients had lower antithrombin activity (-39%) and antigen levels (-23%) compared with controls (both Our study suggests that enhanced thrombin generation and prothrombotic plasma fibrin clot phenotype can contribute to increased risk of thrombosis in patients with antithrombin deficiency.
Sections du résumé
BACKGROUND
BACKGROUND
Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function.
METHODS
METHODS
We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin deficiency and 50 healthy controls. Fibrin clot permeability (K
RESULTS
RESULTS
Antithrombin-deficient patients had lower antithrombin activity (-39%) and antigen levels (-23%) compared with controls (both
CONCLUSION
CONCLUSIONS
Our study suggests that enhanced thrombin generation and prothrombotic plasma fibrin clot phenotype can contribute to increased risk of thrombosis in patients with antithrombin deficiency.
Identifiants
pubmed: 37201530
doi: 10.1055/s-0043-1768712
pmc: PMC10460956
doi:
Substances chimiques
Anticoagulants
0
Antithrombins
0
Fibrin
9001-31-4
Thrombin
EC 3.4.21.5
SERPINC1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
880-891Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Déclaration de conflit d'intérêts
None declared.
Références
Thromb Haemost. 2014 Jul 3;112(1):32-42
pubmed: 24671700
Blood. 2009 Nov 5;114(19):4272-8
pubmed: 19690336
Thromb Haemost. 2017 Aug 30;117(9):1739-1749
pubmed: 28771277
Thromb Res. 2021 Jun;202:45-51
pubmed: 33725558
J Thromb Haemost. 2012 Sep;10(9):1783-91
pubmed: 22812604
Circulation. 2002 Oct 8;106(15):1938-42
pubmed: 12370216
Thromb Haemost. 2014 Sep 2;112(3):478-85
pubmed: 24966143
Thromb Res. 1994 Jul 15;75(2):203-12
pubmed: 7974394
Elife. 2021 Oct 11;10:
pubmed: 34633287
J Thromb Haemost. 2022 Jun;20(6):1350-1363
pubmed: 35352494
Hum Mutat. 2006 Jun;27(6):600
pubmed: 16705712
PLoS One. 2012;7(12):e51447
pubmed: 23240024
J Thromb Haemost. 2018 May;16(5):1007-1012
pubmed: 29658191
Thromb Haemost. 1997 Jan;77(1):197-211
pubmed: 9031473
J Thromb Haemost. 2003 Jul;1(7):1504-14
pubmed: 12871286
Pol Arch Intern Med. 2017 Aug 9;127(7-8):512-523
pubmed: 28607330
Thromb Res. 1980 Oct 15;20(2):207-18
pubmed: 7209877
J Thromb Haemost. 2010 Apr;8(4):845-8
pubmed: 20088933
Arterioscler Thromb Vasc Biol. 2012 May;32(5):1320-4
pubmed: 22362760
Thromb Haemost. 2011 Aug;106(2):379-81
pubmed: 21655678
Chest. 2003 Sep;124(3 Suppl):4S-10S
pubmed: 12970118
Thromb Haemost. 2017 May 3;117(5):880-888
pubmed: 28229161
J Proteomics. 2019 Sep 30;208:103487
pubmed: 31425886
Blood Rev. 2007 May;21(3):131-42
pubmed: 17208341
Haematologica. 2019 Dec;104(12):2512-2518
pubmed: 30975910
Blood. 2022 Jul 14;140(2):140-151
pubmed: 35486842
Thromb Res. 2012 Apr;129(4):e142-6
pubmed: 22245244
Semin Thromb Hemost. 2018 Jun;44(4):315-326
pubmed: 29452444
J Thromb Haemost. 2008 Jan;6(1):125-31
pubmed: 17988231
Thromb Haemost. 2009 Mar;101(3):465-70
pubmed: 19277406
Gastroenterology. 2001 Jul;121(1):131-9
pubmed: 11438502
Thromb Res. 2012 Oct;130(4):e216-21
pubmed: 22940058
Thromb Res. 2012 Sep;130(3):528-34
pubmed: 22704462
Thromb Haemost. 2002 Mar;87(3):551-4
pubmed: 11916097
Haemophilia. 2008 Nov;14(6):1229-39
pubmed: 19141163
J Thromb Haemost. 2016 Aug;14(8):1549-60
pubmed: 27214821
Arch Pathol Lab Med. 2021 Jan 1;145(1):99-104
pubmed: 33367661
J Thromb Haemost. 2018 Apr;16(4):680-688
pubmed: 29377625