Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption.
Compound specific isotope analysis (CSIA)
DHA metabolism
Kinetic modeling
Oxylipins
Specialized pro-resolving mediators
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
21
02
2023
revised:
02
05
2023
accepted:
15
05
2023
medline:
14
7
2023
pubmed:
19
5
2023
entrez:
18
5
2023
Statut:
ppublish
Résumé
Docosahexaenoic acid (DHA, 22:6n-3) accretion in brain phospholipids is critical for maintaining the structural fluidity that permits proper assembly of protein complexes for signaling. Furthermore, membrane DHA can be released by phospholipase A
Identifiants
pubmed: 37201738
pii: S0163-7258(23)00101-8
doi: 10.1016/j.pharmthera.2023.108437
pii:
doi:
Substances chimiques
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108437Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Richard P. Bazinet is supported by grant funding through the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada and holds a Canada Research Chair in Brain Lipid Metabolism. R.P.B. has received industrial grants, including those matched by the Canadian government, and/or travel support related to work on brain fatty acid and oxylipin uptake from Arctic Nutrition, Bunge Ltd., Capsoil Technologies, DSM, Fonterra, Mead Johnson, Natures Crops International, Nestec Inc., and Pharmavite. Moreover, R.P.B. is on the executive committee of the International Society for the Study of Fatty Acids and Lipids and held a meeting on behalf of fatty acids and cell signaling, both of which rely on corporate sponsorship. R.P.B. has given expert testimony in relation to supplements and the brain.