Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust.
Airborne pollution
Diesel exhaust
Gestational exposure
Label-free detection
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
18 05 2023
18 05 2023
Historique:
received:
24
11
2022
accepted:
06
05
2023
medline:
22
5
2023
pubmed:
19
5
2023
entrez:
18
5
2023
Statut:
epublish
Résumé
Airborne pollution particles have been shown to translocate from the mother's lung to the fetal circulation, but their distribution and internal placental-fetal tissue load remain poorly explored. Here, we investigated the placental-fetal load and distribution of diesel engine exhaust particles during gestation under controlled exposure conditions using a pregnant rabbit model. Pregnant dams were exposed by nose-only inhalation to either clean air (controls) or diluted and filtered diesel engine exhaust (1 mg/m CPs were detected in the placenta, fetal heart, kidney, liver, lung and gonads in significantly higher amounts in exposed rabbits compared with controls. Through multiple factor analysis, we were able to discriminate the diesel engine exposed pregnant rabbits from the control group taking all variables related to fetoplacental biometry and CP load into consideration. Our findings did not reveal a sex effect, yet a potential interaction effect might be present between exposure and fetal sex. The results confirmed the translocation of maternally inhaled CPs from diesel engine exhaust to the placenta which could be detected in fetal organs during late-stage pregnancy. The exposed can be clearly discriminated from the control group with respect to fetoplacental biometry and CP load. The differential particle load in the fetal organs may contribute to the effects on fetoplacental biometry and to the malprogramming of the fetal phenotype with long-term effects later in life.
Sections du résumé
BACKGROUND
Airborne pollution particles have been shown to translocate from the mother's lung to the fetal circulation, but their distribution and internal placental-fetal tissue load remain poorly explored. Here, we investigated the placental-fetal load and distribution of diesel engine exhaust particles during gestation under controlled exposure conditions using a pregnant rabbit model. Pregnant dams were exposed by nose-only inhalation to either clean air (controls) or diluted and filtered diesel engine exhaust (1 mg/m
RESULTS
CPs were detected in the placenta, fetal heart, kidney, liver, lung and gonads in significantly higher amounts in exposed rabbits compared with controls. Through multiple factor analysis, we were able to discriminate the diesel engine exposed pregnant rabbits from the control group taking all variables related to fetoplacental biometry and CP load into consideration. Our findings did not reveal a sex effect, yet a potential interaction effect might be present between exposure and fetal sex.
CONCLUSIONS
The results confirmed the translocation of maternally inhaled CPs from diesel engine exhaust to the placenta which could be detected in fetal organs during late-stage pregnancy. The exposed can be clearly discriminated from the control group with respect to fetoplacental biometry and CP load. The differential particle load in the fetal organs may contribute to the effects on fetoplacental biometry and to the malprogramming of the fetal phenotype with long-term effects later in life.
Identifiants
pubmed: 37202804
doi: 10.1186/s12989-023-00531-z
pii: 10.1186/s12989-023-00531-z
pmc: PMC10193698
doi:
Substances chimiques
Vehicle Emissions
0
Carbon
7440-44-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20Informations de copyright
© 2023. The Author(s).
Références
Environ Int. 2021 Jan;146:106274
pubmed: 33395930
Nat Commun. 2019 Sep 17;10(1):3866
pubmed: 31530803
Sci Rep. 2020 Jun 10;10(1):9399
pubmed: 32523064
Placenta. 2017 Jan;49:16-22
pubmed: 28012450
Environ Res. 2016 Apr;146:35-46
pubmed: 26717078
Environ Res. 2021 Nov;202:111728
pubmed: 34297937
Lancet Respir Med. 2013 Nov;1(9):695-704
pubmed: 24429273
Environ Sci Pollut Res Int. 2015 Mar;22(5):3383-96
pubmed: 25163563
Am J Epidemiol. 2016 Sep 15;184(6):442-9
pubmed: 27601048
Nanotoxicology. 2017 Jun;11(5):687-698
pubmed: 28618895
Environ Health Perspect. 2016 Oct;124(10):1608-1615
pubmed: 27120296
Hum Reprod. 1998 Oct;13(1O):2941-9
pubmed: 9804259
J Appl Toxicol. 2021 Oct;41(10):1598-1619
pubmed: 33825214
Ecotoxicol Environ Saf. 2019 Dec 30;186:109755
pubmed: 31605956
Part Fibre Toxicol. 2010 Jun 14;7:16
pubmed: 20546558
Environ Health Perspect. 2015 Aug;123(8):834-40
pubmed: 25816123
Arch Toxicol. 2016 Jul;90(7):1541-53
pubmed: 27165416
PLoS One. 2014 Feb 12;9(2):e88582
pubmed: 24533117
Environ Int. 2019 Mar;124:482-492
pubmed: 30684806
Part Fibre Toxicol. 2020 Oct 24;17(1):55
pubmed: 33099312
Hum Reprod Update. 2003 Nov-Dec;9(6):531-9
pubmed: 14714590
Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:133-66
pubmed: 25475422
Int J Pediatr. 2014;2014:291846
pubmed: 24895497
J Nanobiotechnology. 2021 May 17;19(1):144
pubmed: 34001140
Sci Rep. 2021 Nov 18;11(1):22516
pubmed: 34795349
Chemosphere. 2021 Nov;283:131125
pubmed: 34467953
Adv Mater. 2009;21:419-424
pubmed: 19606281
Nano Lett. 2016 May 11;16(5):3173-8
pubmed: 27104759
Part Fibre Toxicol. 2016 Jul 26;13(1):39
pubmed: 27460165
Part Fibre Toxicol. 2006 May 24;3:8
pubmed: 16723024
Part Fibre Toxicol. 2019 Jan 17;16(1):5
pubmed: 30654819
Lancet Planet Health. 2022 Jun;6(6):e535-e547
pubmed: 35594895
Chem Res Toxicol. 2018 Aug 20;31(8):641-642
pubmed: 30036046
Reproduction. 2012 Jul;144(1):1-10
pubmed: 22580370
Front Pediatr. 2019 Feb 07;7:22
pubmed: 30792973
Placenta. 2022 Apr;121:99-108
pubmed: 35305398
Prenat Diagn. 2014 Jan;34(1):84-9
pubmed: 24151193
FASEB J. 2012 Nov;26(11):4743-54
pubmed: 22815382
Sci Total Environ. 2014 Aug 15;490:785-97
pubmed: 24907613
Reprod Toxicol. 2010 Dec;30(4):600-12
pubmed: 20656020
Part Fibre Toxicol. 2020 Nov 2;17(1):56
pubmed: 33138843
Lancet Planet Health. 2022 Oct;6(10):e804-e811
pubmed: 36208643
Placenta. 2011 Jan;32(1):58-62
pubmed: 21036395
Res Vet Sci. 1995 Jul;59(1):82-6
pubmed: 8525092
Part Fibre Toxicol. 2015 Oct 06;12:30
pubmed: 26437892
Placenta. 1998 Jan;19(1):105-11
pubmed: 9481792
Lancet. 2016 Aug 13;388(10045):696-704
pubmed: 27233746
Ann Endocrinol (Paris). 2016 Jun;77(2):67-74
pubmed: 27155775
Sci Total Environ. 2021 Jan 10;751:142235
pubmed: 33181987
Part Fibre Toxicol. 2014 Sep 10;11:33
pubmed: 25928666
Toxicol Sci. 2012 Apr;126(2):478-86
pubmed: 22240978
Lancet. 2011 Feb 26;377(9767):732-40
pubmed: 21353301
Placenta. 2006 Apr;27 Suppl A:S30-3
pubmed: 16529811
Physiol Rev. 2012 Oct;92(4):1543-76
pubmed: 23073626
Part Fibre Toxicol. 2020 Jul 11;17(1):31
pubmed: 32653006
J Toxicol Pathol. 2014 Apr;27(1):11-8
pubmed: 24791062
Environ Health Prev Med. 2021 Jul 12;26(1):72
pubmed: 34253165
Environ Health. 2020 Dec 7;19(1):129
pubmed: 33287817
Environ Health. 2016 Jan 20;15:10
pubmed: 26792633
Lancet. 1993 Apr 10;341(8850):938-41
pubmed: 8096277
Pediatr Neonatol. 2020 Apr;61(2):231-237
pubmed: 31818536
Med Sci Monit. 2016 Sep 15;22:3274-80
pubmed: 27629830
Environ Res. 2021 Sep;200:111690
pubmed: 34273365
Endocrinology. 2015 Oct;156(10):3422-34
pubmed: 26241064