Type I and III interferons shape the retinal cytokine network and barrier function in an
Toxoplasma gondii
barrier function
inflammation
interferons
ocular immunology
retina
tight junctions
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
01
2023
accepted:
11
04
2023
medline:
22
5
2023
pubmed:
19
5
2023
entrez:
19
5
2023
Statut:
epublish
Résumé
The particularities of the ocular immune environment and its barrier protection in the context of infection are not well elucidated. The apicomplexan parasite As a first approach, we studied the initial cytokine network in vitro in four human cell lines: Retinal pigmented epithelial (RPE), microglial, astrocytic and Müller cells. Furthermore, we looked at the consequences of retinal infection on the integrity of the outer blood-retina barrier (oBRB). We particularly focused on the roles of type I and type III interferons, (IFN-β and IFN-λ). Especially IFN-λ is known for its significant role in barrier defense. However, its effect on the retinal barrier or Here, we show that stimulation with type I and III interferons did not limit parasite proliferation in retinal cells we tested. However, IFN-β and IFN-γ strongly induced inflammatory or cell-attracting cytokine production, whereas IFN-λ1 showed less inflammatory activity. Concomitant Together, our model shows how
Identifiants
pubmed: 37205102
doi: 10.3389/fimmu.2023.1148037
pmc: PMC10188120
doi:
Substances chimiques
Interferons
9008-11-1
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1148037Informations de copyright
Copyright © 2023 Geiller, Greigert, Hillenbrand, Gommenginger, Beal, Brunet, Filisetti, Villard, Denis and Pfaff.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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