Cancer resistance via the downregulation of the tumor suppressors
PTEN
RKIP
bioinformatics
cross-talks
resistance
signaling
Journal
Exploration of targeted anti-tumor therapy
ISSN: 2692-3114
Titre abrégé: Explor Target Antitumor Ther
Pays: United States
ID NLM: 101770662
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
09
2022
accepted:
12
12
2022
medline:
19
5
2023
pubmed:
19
5
2023
entrez:
19
5
2023
Statut:
ppublish
Résumé
The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell resistance to cytotoxic drugs/cells. Likewise, the tumor suppressor, phosphatase and tensin homolog (PTEN), which inhibits the phosphatidylinositol 3 kinase (PI3K)/AKT pathway, is either mutated, underexpressed, or deleted in many cancers and shares with RKIP its anti-tumor properties and its regulation in resistance. The transcriptional and posttranscriptional regulations of RKIP and PTEN expressions and their roles in resistance were reviewed. The underlying mechanism of the interrelationship between the signaling expressions of RKIP and PTEN in cancer is not clear. Several pathways are regulated by RKIP and PTEN and the transcriptional and post-transcriptional regulations of RKIP and PTEN is significantly altered in cancers. In addition, RKIP and PTEN play a key role in the regulation of tumor cells response to chemotherapy and immunotherapy. In addition, molecular and bioinformatic data revealed crosstalk signaling networks that regulate the expressions of both
Identifiants
pubmed: 37205308
doi: 10.37349/etat.2023.00128
pii: etat-04-1002128
pmc: PMC10185445
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
170-207Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Cell. 1998 Oct 2;95(1):29-39
pubmed: 9778245
J Biol Chem. 2005 Oct 21;280(42):35195-202
pubmed: 16107342
Oncol Lett. 2020 Dec;20(6):347
pubmed: 33123258
Cancer Res. 2000 Mar 15;60(6):1541-5
pubmed: 10749120
Oncogene. 2008 Apr 3;27(15):2243-8
pubmed: 17952120
Crit Rev Oncog. 2014;19(6):431-45
pubmed: 25597353
Cancer Res. 2016 Jun 15;76(12):3644-54
pubmed: 27197200
J Cancer. 2010 Sep 15;1:136-40
pubmed: 20922055
PLoS One. 2013 Dec 26;8(12):e83097
pubmed: 24386147
Cell Biosci. 2022 Apr 27;12(1):50
pubmed: 35477555
Cancer Discov. 2011 Jul;1(2):158-69
pubmed: 21984975
J Clin Invest. 2019 Feb 1;129(2):452-464
pubmed: 30614812
Biochem Biophys Res Commun. 2018 Aug 25;502(4):493-500
pubmed: 29859193
Genes Chromosomes Cancer. 1992 Jul;5(1):75-82
pubmed: 1384665
Mol Cell Biochem. 2016 Nov;422(1-2):161-170
pubmed: 27644195
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102
pubmed: 28407145
Clin Cancer Res. 2021 Jul 1;27(13):3714-3724
pubmed: 33926917
Crit Rev Oncog. 2011;16(3-4):211-26
pubmed: 22248055
Cancer Res. 1997 Jun 1;57(11):2124-9
pubmed: 9187108
Pathobiology. 2016;83(1):41-6
pubmed: 26859895
Front Oncol. 2019 May 08;9:357
pubmed: 31139560
Pathology. 2012 Oct;44(6):534-9
pubmed: 22935977
Front Immunol. 2022 Feb 08;13:828875
pubmed: 35211123
Mol Cancer Res. 2009 Feb;7(2):221-9
pubmed: 19208738
Crit Rev Oncog. 2014;19(6):447-54
pubmed: 25597354
Oncotarget. 2014 Sep 15;5(17):7406-19
pubmed: 25277181
Pharmaceutics. 2022 Mar 08;14(3):
pubmed: 35335966
J Biol Chem. 2012 Sep 28;287(40):33533-44
pubmed: 22875853
Cold Spring Harb Perspect Med. 2020 Jan 2;10(1):
pubmed: 31548229
Cells. 2020 Jul 18;9(7):
pubmed: 32708484
Science. 1997 Mar 28;275(5308):1943-7
pubmed: 9072974
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14794-9
pubmed: 25267645
J Exp Clin Cancer Res. 2017 May 5;36(1):62
pubmed: 28476134
J Exp Clin Cancer Res. 2021 Jan 6;40(1):9
pubmed: 33407724
For Immunopathol Dis Therap. 2011;2(1):89-94
pubmed: 21984962
Cancer Lett. 2016 Oct 1;380(2):384-392
pubmed: 27424289
J Biol Chem. 2005 Jul 1;280(26):24931-40
pubmed: 15886202
J Cell Physiol. 2018 Sep;233(9):6508-6517
pubmed: 29574790
Cell Physiol Biochem. 2012;30(6):1340-50
pubmed: 23095933
Sci Signal. 2010 Apr 13;3(117):ra29
pubmed: 20388916
For Immunopathol Dis Therap. 2011;2(1):1-12
pubmed: 23227430
Cell. 1999 Mar 19;96(6):857-68
pubmed: 10102273
Oncogene. 2005 Mar 10;24(11):1882-94
pubmed: 15674339
J Cell Biochem. 2017 Dec;118(12):4498-4507
pubmed: 28464252
Int J Biochem Cell Biol. 2008;40(5):874-91
pubmed: 18280770
Mol Cancer. 2014 Aug 16;13:193
pubmed: 25128483
Cancer Res. 2019 May 1;79(9):2232-2243
pubmed: 30833420
Genes Cancer. 2011 Mar;2(3):232-60
pubmed: 21779496
Mol Biosyst. 2011 Mar;7(3):928-41
pubmed: 21180766
Sci Rep. 2017 Feb 01;7:41330
pubmed: 28145479
Nat Genet. 1997 May;16(1):64-7
pubmed: 9140396
Oncogene. 1998 Jul 9;17(1):123-7
pubmed: 9671321
Am J Pathol. 2001 Jun;158(6):2097-106
pubmed: 11395387
Cancer Res. 1993 Oct 15;53(20):5043-50
pubmed: 8104691
Eur J Pharmacol. 2020 Aug 5;880:173138
pubmed: 32416187
Clin Cancer Res. 1998 Mar;4(3):811-5
pubmed: 9533551
J Biol Chem. 2006 Mar 24;281(12):7727-36
pubmed: 16418168
Tumour Biol. 2017 Apr;39(4):1010428317692253
pubmed: 28378634
Hereditas. 1984;101(1):103-13
pubmed: 6490389
Curr Biol. 2001 May 15;11(10):764-8
pubmed: 11378386
Tumour Biol. 2016 Jul;37(7):8941-9
pubmed: 26753960
Cancer Res. 2012 Jun 15;72(12):3091-104
pubmed: 22505648
Genes Chromosomes Cancer. 1998 Feb;21(2):166-71
pubmed: 9491329
Mol Cell Biol. 2004 Feb;24(3):1007-21
pubmed: 14729949
Sci Transl Med. 2021 Jun 23;13(599):
pubmed: 34162754
Med Sci Monit. 2019 Dec 16;25:9609-9617
pubmed: 31840653
Cancers (Basel). 2018 Aug 24;10(9):
pubmed: 30149591
J Transl Med. 2020 Jan 30;18(1):45
pubmed: 32000794
Biochem Biophys Res Commun. 2010 Aug 27;399(3):313-7
pubmed: 20674547
Crit Rev Oncog. 2018;23(5-6):307-320
pubmed: 30311562
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1873-9
pubmed: 19098317
Mol Cell Biol. 2001 Jun;21(12):3995-4004
pubmed: 11359907
Cells. 2020 Apr 30;9(5):
pubmed: 32365809
Biochem Soc Trans. 2008 Dec;36(Pt 6):1224-31
pubmed: 19021530
Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118659
pubmed: 31978503
Nat Commun. 2020 Feb 5;11(1):737
pubmed: 32024819
Cancer Gene Ther. 2021 Nov;28(10-11):1099-1112
pubmed: 33323961
J Cell Biochem. 2017 Jul;118(7):1889-1899
pubmed: 28121023
Genes Chromosomes Cancer. 2004 Oct;41(2):117-24
pubmed: 15287024
Front Endocrinol (Lausanne). 2018 Jul 09;9:338
pubmed: 30038596
Oncol Lett. 2015 Jan;9(1):15-24
pubmed: 25435928
J Exp Clin Cancer Res. 2017 Jan 26;36(1):19
pubmed: 28126034
PLoS One. 2014 Oct 16;9(10):e109285
pubmed: 25329396
Front Oncol. 2021 Mar 09;11:614035
pubmed: 33767986
J Immunol. 2007 Oct 15;179(8):5441-53
pubmed: 17911631
Neurooncol Adv. 2019 Dec 26;2(1):vdz058
pubmed: 32642723
Biochem Pharmacol. 2004 Sep 15;68(6):1049-53
pubmed: 15313400
Structure. 1998 Oct 15;6(10):1245-54
pubmed: 9782050
FEBS Lett. 2010 Feb 19;584(4):662-8
pubmed: 20043910
Front Endocrinol (Lausanne). 2016 Jan 11;6:188
pubmed: 26793165
Front Immunol. 2017 Dec 11;8:1653
pubmed: 29312284
Adv Biol Regul. 2017 Aug;65:5-15
pubmed: 28712664
Acta Biochim Pol. 2020 Dec 17;67(4):515-519
pubmed: 33332075
Anticancer Res. 2009 Jan;29(1):159-64
pubmed: 19331146
Cell J. 2022 Mar;24(3):112-119
pubmed: 35451580
J Biol Chem. 2007 Feb 9;282(6):3507-19
pubmed: 17158870
Nat Cell Biol. 2001 Dec;3(12):1124-8
pubmed: 11781575
Nitric Oxide. 2011 Jan 1;24(1):1-7
pubmed: 20933602
Gastroenterology. 2007 Aug;133(2):647-58
pubmed: 17681183
Int J Clin Exp Pathol. 2019 Jun 01;12(6):2339-2352
pubmed: 31934061
J Clin Oncol. 2002 Feb 1;20(3):719-26
pubmed: 11821453
Oncol Lett. 2022 Jan;23(1):24
pubmed: 34868361
EMBO J. 2009 Feb 18;28(4):347-58
pubmed: 19153603
Hum Pathol. 2013 Jun;44(6):1024-30
pubmed: 23260327
For Immunopathol Dis Therap. 2013;4(1):
pubmed: 24187651
Biomaterials. 2012 Apr;33(10):2902-15
pubmed: 22244698
J Cell Biochem. 2005 Feb 1;94(2):273-8
pubmed: 15565643
J Immunol. 2008 May 1;180(9):6199-210
pubmed: 18424742
For Immunopathol Dis Therap. 2011 Apr 1;2(2):
pubmed: 24286018
Cancer Biomark. 2017;18(2):177-182
pubmed: 27983532
J Biol Chem. 2001 Jan 12;276(2):993-8
pubmed: 11035045
J Cell Biol. 2006 Apr 10;173(1):133-44
pubmed: 16606695
Mol Cancer. 2018 Feb 19;17(1):37
pubmed: 29455665
Cancer Cell. 2003 Aug;4(2):147-58
pubmed: 12957289
J Immunol. 2009 Jan 15;182(2):1138-45
pubmed: 19124757
PLoS One. 2014 Apr 28;9(4):e95219
pubmed: 24777052
Biochim Biophys Acta. 2007 Apr;1768(4):913-22
pubmed: 17084806
Biochem Biophys Res Commun. 2012 Aug 24;425(2):127-33
pubmed: 22809510
J Mol Biol. 2001 Jul 13;310(3):617-34
pubmed: 11439028
Cell Death Dis. 2017 May 18;8(5):e2796
pubmed: 28518139
Oncogenesis. 2012 Jun 04;1:e12
pubmed: 23552696
PLoS One. 2012;7(4):e36187
pubmed: 22558375
FEBS Lett. 2002 Sep 25;528(1-3):145-53
pubmed: 12297295
Int J Oncol. 2011 Jun;38(6):1683-94
pubmed: 21455568
Cancers (Basel). 2018 Sep 04;10(9):
pubmed: 30181452
Nat Rev Cancer. 2011 Apr;11(4):289-301
pubmed: 21430697
Genes Cancer. 2010 May;1(5):409-420
pubmed: 20827424
Sci Rep. 2016 Sep 13;6:32723
pubmed: 27620353
PLoS One. 2017 Jun 29;12(6):e0178865
pubmed: 28662101
Front Cell Dev Biol. 2021 Mar 16;9:626229
pubmed: 33796526
Cancer Cell. 2019 Jun 10;35(6):830-849
pubmed: 31105042
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
J Pers Med. 2021 Jul 19;11(7):
pubmed: 34357143
Breast Cancer Res Treat. 2019 Jul;176(2):291-301
pubmed: 31006103
Cancer Res. 2008 Sep 15;68(18):7638-49
pubmed: 18794153
Int J Mol Med. 2021 Jun;47(6):
pubmed: 33846767
Curr Protein Pept Sci. 2015;16(4):279-94
pubmed: 25929862
Cells. 2020 Apr 16;9(4):
pubmed: 32316260
Front Oncol. 2015 Jul 27;5:166
pubmed: 26284192
Semin Cancer Biol. 2019 Dec;59:66-79
pubmed: 30738865
Crit Rev Oncog. 2014;19(6):455-68
pubmed: 25597355
J Natl Cancer Inst. 2003 Jun 18;95(12):878-89
pubmed: 12813171
Mol Cancer. 2020 Jun 24;19(1):109
pubmed: 32580736
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E364-73
pubmed: 24395801
Cancer Res. 1988 Jan 15;48(2):405-11
pubmed: 3335011
Cancers (Basel). 2022 Feb 12;14(4):
pubmed: 35205667
Elife. 2014 Mar 18;3:e01998
pubmed: 24642411
Crit Rev Oncog. 2014;19(6):483-8
pubmed: 25597357
J Exp Clin Cancer Res. 2019 Mar 29;38(1):141
pubmed: 30925916
Clin Cancer Res. 2005 Oct 15;11(20):7392-7
pubmed: 16243812
Cancer Discov. 2016 Feb;6(2):202-16
pubmed: 26645196
Annu Rev Immunol. 2000;18:621-63
pubmed: 10837071
Mol Cell Biol. 2002 Oct;22(20):7004-14
pubmed: 12242281
Crit Rev Oncog. 2018;23(5-6):281-305
pubmed: 30311561
J Cell Physiol. 2013 Aug;228(8):1688-702
pubmed: 23359513
Cell Signal. 2008 May;20(5):935-41
pubmed: 18294816
Cancer Cell. 2004 Aug;6(2):117-27
pubmed: 15324695
Oncotarget. 2014 May 30;5(10):2974-87
pubmed: 24912422
PLoS One. 2010 May 05;5(5):e10479
pubmed: 20463977
Nitric Oxide. 2008 Sep;19(2):152-7
pubmed: 18477483
Cancer Biol Ther. 2012 Sep;13(11):1102-11
pubmed: 22895065
Cancer Biol Ther. 2009 Jul;8(14):1389-401
pubmed: 19483472
Cancers (Basel). 2020 Jun 03;12(6):
pubmed: 32503139
Adv Cancer Res. 2004;91:169-200
pubmed: 15327891
J Biol Chem. 2014 Jun 27;289(26):18152-62
pubmed: 24828497
Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562
pubmed: 29858604
J Ovarian Res. 2019 Dec 9;12(1):121
pubmed: 31815639
Am J Cancer Res. 2013 Nov 01;3(5):446-64
pubmed: 24224123
Histol Histopathol. 2013 Mar;28(3):285-92
pubmed: 23348381
Mol Cancer. 2009 Nov 10;8:98
pubmed: 19903340
Crit Rev Immunol. 2010;30(1):31-46
pubmed: 20370618
J Biol Chem. 2012 Aug 10;287(33):27843-50
pubmed: 22700976
Cancer Res. 1997 Sep 15;57(18):3935-40
pubmed: 9307275
Cell Physiol Biochem. 2017;41(3):1135-1146
pubmed: 28245474
Cancer Metastasis Rev. 2012 Dec;31(3-4):615-20
pubmed: 22684368
EMBO J. 2011 Aug 26;30(21):4500-14
pubmed: 21873975
Biophys Rev. 2019 Feb;11(1):51-54
pubmed: 30684131
J Biol Chem. 2012 Jul 6;287(28):23407-17
pubmed: 22610096
Cell Biosci. 2019 Oct 02;9:81
pubmed: 31592114
J Clin Oncol. 1999 Sep;17(9):2639-48
pubmed: 10561337
J Immunol. 2010 Jul 15;185(2):990-7
pubmed: 20548023
Mol Cancer. 2013 Aug 02;12:86
pubmed: 23915189
Nat Rev Genet. 2006 Aug;7(8):606-19
pubmed: 16847462
J Immunol. 2001 Jul 1;167(1):75-81
pubmed: 11418634
Eur J Pharmacol. 2016 Aug 15;785:44-49
pubmed: 26632493
Nature. 1999 Sep 9;401(6749):173-7
pubmed: 10490027
Mol Cancer. 2018 Jun 12;17(1):94
pubmed: 29895332