Prolonged activation of EP3 receptor-expressing preoptic neurons underlies torpor responses.


Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
02 May 2023
Historique:
pubmed: 19 5 2023
medline: 19 5 2023
entrez: 19 5 2023
Statut: epublish

Résumé

Many species use a temporary drop in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity. A similar profound hypothermia is observed with activation of preoptic neurons that express the neuropeptides Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP)

Identifiants

pubmed: 37205518
doi: 10.21203/rs.3.rs-2861253/v1
pmc: PMC10187418
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS112175
Pays : United States

Déclaration de conflit d'intérêts

Potential conflicting interests: None

Auteurs

Natalia L S Machado (NLS)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Francesca Raffin (F)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Satvinder Kaur (S)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Alexander S Banks (AS)

Division of Endocrinology, Metabolism, and Diabetes, Beth Israel-Deaconess Medical Center and Harvard Medical School, Boston 02215 USA.

Nicole Lynch (N)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Oleksandra Fanari (O)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Oscar R Plascencia (OR)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Sydney Aten (S)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Janayna D Lima (JD)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Sathyajit S Bandaru (SS)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Richard D Palmiter (RD)

Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, 1959 NE Pacific St., Seattle WA 98195-7370 USA.

Elda Arrigoni (E)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Clifford B Saper (CB)

Department of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.

Classifications MeSH