Severe Postnatal Cytomegalovirus Enterocolitis in Immunocompetent Term Infants Requiring Total Parenteral Nutrition.

cytomegalovirus enterocolitis ganciclovir immunocompetent secretory diarrhea

Journal

JPGN reports
ISSN: 2691-171X
Titre abrégé: JPGN Rep
Pays: United States
ID NLM: 101773885

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 20 11 2020
accepted: 10 06 2021
medline: 22 7 2021
pubmed: 22 7 2021
entrez: 19 5 2023
Statut: epublish

Résumé

Postnatal cytomegalovirus enterocolitis is uncommon in immunocompetent infants. We report a 10-week-old term boy with severe and prolonged secretory diarrhea, leading to dependence on total parenteral nutrition and a 10-week hospitalization. Cytomegalovirus enterocolitis was diagnosed based on duodenal biopsy in the context of marked viremia, and the child recovered promptly on initiation of ganciclovir. Collated case reports reveal delayed diagnoses as the norm but rapid improvement with antiviral treatment. Cytomegalovirus enterocolitis should be considered early as a differential diagnosis in infants with refractory diarrhea.

Identifiants

pubmed: 37205973
doi: 10.1097/PG9.0000000000000110
pmc: PMC10191544
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e110

Informations de copyright

Copyright © 2021 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest.

Références

J Paediatr Child Health. 2004 Sep-Oct;40(9-10):581-2
pubmed: 15367158
Front Immunol. 2014 Oct 30;5:552
pubmed: 25400639
J Pediatric Infect Dis Soc. 2013 Mar;2(1):71-5
pubmed: 26619446
Gastroenterology. 2018 Jun;154(8):2045-2059.e6
pubmed: 29654747
Microbiol Spectr. 2016 Aug;4(4):
pubmed: 27726793
J Clin Virol. 2014 Apr;59(4):259-63
pubmed: 24553057
J Pediatr Surg. 2006 Nov;41(11):1826-9
pubmed: 17101352
J Paediatr Child Health. 2018 Apr;54(4):460
pubmed: 29611315
Am J Gastroenterol. 1998 Jun;93(6):1005-6
pubmed: 9647040
Arch Dis Child. 1987 Aug;62(8):780-5
pubmed: 2821927
J Pathol Transl Med. 2015 May;49(3):270-3
pubmed: 26018521
Pediatr Emerg Care. 2005 Feb;21(2):130-3
pubmed: 15699825
BMC Pediatr. 2011 Jun 06;11:52
pubmed: 21645352
Pediatr Infect Dis J. 2016 May;35(5):573-6
pubmed: 26862673
J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):203-5
pubmed: 18664875
Pediatrics. 1999 Jan;103(1):E10
pubmed: 9917490
Microorganisms. 2020 May 08;8(5):
pubmed: 32397070
J Clin Virol. 2011 Feb;50(2):97-9
pubmed: 21106437
J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):111-3
pubmed: 19779376
J Pediatr Surg. 1997 Nov;32(11):1545-7
pubmed: 9396521
Rev Med Virol. 2010 Jul;20(4):202-13
pubmed: 20564615
J Immunol. 2018 Jun 15;200(12):3881-3889
pubmed: 29866770
Minn Med. 2014 Sep;97(9):50
pubmed: 25282774
BMJ Case Rep. 2012 Jun 14;2012:
pubmed: 22707698
Pediatr Infect Dis J. 2001 May;20(5):545-6
pubmed: 11368118
An Esp Pediatr. 1975 Nov-Dec;8(6):603-8
pubmed: 174467
J Pediatr. 1996 Dec;129(6):931-4
pubmed: 8969741
Arch Pediatr. 2014 Sep;21(9):1016-9
pubmed: 24997060
Pediatr Infect Dis J. 2004 Jun;23(6):579-81
pubmed: 15194846
J Pediatr Gastroenterol Nutr. 1999 Jul;29(1):86-90
pubmed: 10400111
An Pediatr (Barc). 2009 Jun;70(6):582-5
pubmed: 19423414
Eur J Pediatr. 1997 Jul;156(7):528-9
pubmed: 9243233

Auteurs

Annaleise R Howard-Jones (AR)

From the Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Discipline of Child and Adolescent Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Giancarlo H Cristerna-Tarrasa (GH)

Department of Infectious Diseases, Instituto Nacional de Pediatría, Mexico City, Mexico.

Rabia Khan (R)

Department of Gastroenterology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Michael Stormon (M)

Discipline of Child and Adolescent Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Department of Gastroenterology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Susan Arbuckle (S)

Discipline of Child and Adolescent Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Department of Histopathology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Philip N Britton (PN)

From the Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Discipline of Child and Adolescent Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Classifications MeSH