Substantiate a read-across hypothesis by using transcriptome data-A case study on volatile diketones.

PBEC TempO-seq new approach methodology protein network analysis read across transcriptomics

Journal

Frontiers in toxicology
ISSN: 2673-3080
Titre abrégé: Front Toxicol
Pays: Switzerland
ID NLM: 101777990

Informations de publication

Date de publication:
2023
Historique:
received: 31 01 2023
accepted: 17 04 2023
medline: 19 5 2023
pubmed: 19 5 2023
entrez: 19 5 2023
Statut: epublish

Résumé

This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference

Identifiants

pubmed: 37206915
doi: 10.3389/ftox.2023.1155645
pii: 1155645
pmc: PMC10188990
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1155645

Informations de copyright

Copyright © 2023 Drake, Wehr, Zobl, Koschmann, De Lucca, Kühne, Hansen, Knebel, Ritter, Boei, Vrieling, Bitsch and Escher.

Déclaration de conflit d'intérêts

JK was employed by GeneXplain GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Christina Drake (C)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Matthias M Wehr (MM)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Walter Zobl (W)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Jeannette Koschmann (J)

GeneXplain GmbH, Wolfenbüttel, Germany.

David De Lucca (D)

Medizinische Hochschule Hannover, Hannover, Germany.

Britta A Kühne (BA)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Tanja Hansen (T)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Jan Knebel (J)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Detlef Ritter (D)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Jan Boei (J)

Leiden University Medical Center, Leiden, Netherlands.

Harry Vrieling (H)

Leiden University Medical Center, Leiden, Netherlands.

Annette Bitsch (A)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Sylvia E Escher (SE)

Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.

Classifications MeSH