How much obesity and diabetes do impair male fertility?
Diabetic men
Hormonal dysfunction
Inflammatory
Metabolic dysfunction
Obese men
Sub fertility
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
13
12
2021
accepted:
08
11
2022
medline:
22
5
2023
pubmed:
20
5
2023
entrez:
19
5
2023
Statut:
epublish
Résumé
Subfertility in obese and diabetic men during the reproductive age is evident, but the mechanisms by which obesity and diabetes mellitus cause male infertility are not entirely understood. The current study aimed to evaluate the effects and potential mechanisms of obesity and diabetes on male fertility. We enrolled control = 40, obese = 40, Lean-DM = 35, and Obese-DM = 35 individuals. The obesity-associated markers, diabetic markers, hormonal and lipid profile, inflammatory indices, and semen analysis were assessed in four experimental groups. Our finding showed that diabetic markers were significantly increased in two diabetic groups, while obesity indices were markedly increased in two obese groups. Conventional sperm parameters were significantly lower in three groups compared with the control. Serum levels of total testosterone and sex hormone-binding globulin were significantly lower in men with obesity and DM compared with the control. There was a significant difference in the concentration of high-sensitivity C-reactive protein among four experimental groups. Moreover, serum leptin was significantly increased in obese DM, lean DM, and obese groups. Serum insulin levels had a positive correlation with metabolic-associated indices and high-sensitivity C-reactive protein levels, whereas it had a negative correlation with count, motility, and morphology. Our findings showed the metabolic changes, hormonal dysfunction and inflammatory disturbance might be suspected mechanisms of subfertility in obese and diabetic subfertile men.
Sections du résumé
BACKGROUND
BACKGROUND
Subfertility in obese and diabetic men during the reproductive age is evident, but the mechanisms by which obesity and diabetes mellitus cause male infertility are not entirely understood. The current study aimed to evaluate the effects and potential mechanisms of obesity and diabetes on male fertility.
METHODS
METHODS
We enrolled control = 40, obese = 40, Lean-DM = 35, and Obese-DM = 35 individuals. The obesity-associated markers, diabetic markers, hormonal and lipid profile, inflammatory indices, and semen analysis were assessed in four experimental groups.
RESULTS
RESULTS
Our finding showed that diabetic markers were significantly increased in two diabetic groups, while obesity indices were markedly increased in two obese groups. Conventional sperm parameters were significantly lower in three groups compared with the control. Serum levels of total testosterone and sex hormone-binding globulin were significantly lower in men with obesity and DM compared with the control. There was a significant difference in the concentration of high-sensitivity C-reactive protein among four experimental groups. Moreover, serum leptin was significantly increased in obese DM, lean DM, and obese groups. Serum insulin levels had a positive correlation with metabolic-associated indices and high-sensitivity C-reactive protein levels, whereas it had a negative correlation with count, motility, and morphology.
CONCLUSIONS
CONCLUSIONS
Our findings showed the metabolic changes, hormonal dysfunction and inflammatory disturbance might be suspected mechanisms of subfertility in obese and diabetic subfertile men.
Identifiants
pubmed: 37208686
doi: 10.1186/s12958-022-01034-w
pii: 10.1186/s12958-022-01034-w
pmc: PMC10197395
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
48Informations de copyright
© 2023. The Author(s).
Références
Clin Endocrinol (Oxf). 2015 Dec;83(6):828-33
pubmed: 25777143
Int J Impot Res. 2006 Mar-Apr;18(2):190-7
pubmed: 16136189
Front Endocrinol (Lausanne). 2019 Aug 13;10:540
pubmed: 31456748
Nature. 2006 Dec 14;444(7121):840-6
pubmed: 17167471
Fertil Steril. 2004 Oct;82(4):863-70
pubmed: 15482761
Hum Reprod. 2014 Feb;29(2):193-200
pubmed: 24306102
J Nutr Metab. 2012;2012:476380
pubmed: 22523672
Metabolism. 2013 Apr;62(4):457-78
pubmed: 22999785
Hum Reprod Update. 2013 May-Jun;19(3):221-31
pubmed: 23242914
Cell J. 2019 Oct;21(3):307-313
pubmed: 31210437
Front Endocrinol (Lausanne). 2018 Jan 05;8:367
pubmed: 29354094
Clin Med Insights Endocrinol Diabetes. 2017 May 19;10:1179551417710209
pubmed: 28579862
Nat Rev Neurosci. 2018 Feb 16;19(3):153-165
pubmed: 29449715
PLoS One. 2018 Mar 16;13(3):e0194395
pubmed: 29547878
Diabetes Res Clin Pract. 2014 Feb;103(2):137-49
pubmed: 24630390
Spermatogenesis. 2012 Oct 1;2(4):253-263
pubmed: 23248766
Clin Endocrinol (Oxf). 2012 May;76(5):665-73
pubmed: 21854402
Prim Care Diabetes. 2012 Jul;6(2):143-8
pubmed: 21982717
Med J Aust. 2006 Oct 16;185(8):424-7
pubmed: 17137431
FEBS Lett. 2008 Jan 9;582(1):97-105
pubmed: 18053812
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
JAMA. 2002 Jan 16;287(3):356-9
pubmed: 11790215
Anat Rec. 1993 Apr;235(4):547-59
pubmed: 8385423
West Afr J Med. 2011 Jul-Aug;30(4):277-81
pubmed: 22669833
World J Mens Health. 2013 Aug;31(2):136-40
pubmed: 24044108
PLoS One. 2013;8(1):e55084
pubmed: 23383064
Front Physiol. 2018 Jan 04;8:1117
pubmed: 29354072
Pancreas. 2014 Nov;43(8):1291-8
pubmed: 25036911
PLoS One. 2016 Jan 04;11(1):e0146304
pubmed: 26726884
Biochim Biophys Acta. 2014 Mar;1842(3):414-23
pubmed: 23685313
J Clin Med. 2021 Apr 02;10(7):
pubmed: 33918143
Tissue Barriers. 2013 Apr 1;1(2):e23992
pubmed: 24665384
Diabetes Care. 1991 Mar;14(3):173-94
pubmed: 2044434
J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51
pubmed: 21896895
Int J Androl. 2003 Oct;26(5):279-85
pubmed: 14511216
Front Endocrinol (Lausanne). 2022 Apr 28;13:897029
pubmed: 35574022
Front Endocrinol (Lausanne). 2018 May 25;9:268
pubmed: 29887834
Acta Diabetol. 2014 Feb;51(1):123-31
pubmed: 24370923
J Clin Endocrinol Metab. 2011 Aug;96(8):2341-53
pubmed: 21646372
Andrologia. 2012 May;44 Suppl 1:565-70
pubmed: 21919944
World J Mens Health. 2019 May;37(2):113-127
pubmed: 30350486
J Assist Reprod Genet. 2016 Sep;33(9):1239-46
pubmed: 27364628
Asian J Androl. 2017 May-Jun;19(3):368-373
pubmed: 27004539
Nat Med. 2012 Mar 06;18(3):363-74
pubmed: 22395709
Asian J Androl. 2010 Jul;12(4):480-9
pubmed: 20531281
Front Endocrinol (Lausanne). 2019 Jul 25;10:345
pubmed: 31402895
J Reprod Infertil. 2015 Jul-Sep;16(3):123-9
pubmed: 26913230
Cent Eur J Immunol. 2015;40(3):337-44
pubmed: 26648778
Diabetes Care. 2018 Jan;41(Suppl 1):S55-S64
pubmed: 29222377
Cent European J Urol. 2015;68(1):79-85
pubmed: 25914843
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368