DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation.

DNA methylation DNAmFitAge Regular exercise Slower aging Systemic adaptation

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
10 2023
Historique:
received: 01 03 2023
accepted: 10 05 2023
medline: 15 11 2023
pubmed: 20 5 2023
entrez: 20 5 2023
Statut: ppublish

Résumé

DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33-88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO

Identifiants

pubmed: 37209203
doi: 10.1007/s11357-023-00826-1
pii: 10.1007/s11357-023-00826-1
pmc: PMC10643800
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2805-2817

Subventions

Organisme : NIA NIH HHS
ID : U01 AG060908
Pays : United States
Organisme : NIH HHS
ID : 1U01AG060908
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052374
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES003598
Pays : United States
Organisme : NIH HHS
ID : # ES003598 # AG052374
Pays : United States
Organisme : NIEHS NIH HHS
ID : R56 ES003598
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Matyas Jokai (M)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Ferenc Torma (F)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Sports Neuroscience Division, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Tsukuba, 305-8574, Japan.
Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Tsukuba, 305-8574, Japan.

Kristen M McGreevy (KM)

Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Erika Koltai (E)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Zoltan Bori (Z)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Gergely Babszki (G)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Peter Bakonyi (P)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Zoltan Gombos (Z)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Bernadett Gyorgy (B)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Dora Aczel (D)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Laszlo Toth (L)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Peter Osvath (P)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Marcell Fridvalszky (M)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Timea Teglas (T)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Aniko Posa (A)

Interdisciplinary Excellence Center, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6700, Szeged, Hungary.

Sylwester Kujach (S)

Department of Physiology, Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland.

Robert Olek (R)

Department of Athletics, Strength and Conditioning, Poznań University of Physical Education, Poznań, Poland.

Takuji Kawamura (T)

Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.

Yasuhiro Seki (Y)

Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.

Katsuhiko Suzuki (K)

Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.

Kumpei Tanisawa (K)

Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.

Sataro Goto (S)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

Csaba Kerepesi (C)

Institute for Computer Science and Control (SZTAKI), Eötvös Loránd Research Network, Budapest, Hungary.

Istvan Boldogh (I)

Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.

Xueqing Ba (X)

Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, Jilin, China.

Kelvin J A Davies (KJA)

Ethel Percy Andrus Gerontology Centre of the Leonard Davis School of Gerontology; Division of Molecular & Computational Biology, Department of Biological Sciences, of the Dornsife College of Letters, Arts, and Sciences; and Department of Biochemistry & Molecular Medicine of the USC Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089-0191, USA.

Steve Horvath (S)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Altos Labs, Cambridge Institute of Science, Cambridge, UK.

Zsolt Radak (Z)

Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary. radak.zsolt@tf.hu.
Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan. radak.zsolt@tf.hu.

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