Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.
CREB
Developmental toxicity
Environmental chemicals
Reproductive toxicity
Testicular dysgenesis syndrome
Journal
Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
12
02
2023
revised:
16
05
2023
accepted:
17
05
2023
pmc-release:
01
06
2024
medline:
15
6
2023
pubmed:
21
5
2023
entrez:
20
5
2023
Statut:
ppublish
Résumé
Environmental chemical (EC) exposure may be impacting male reproductive health. The translationally relevant biosolids treated pasture (BTP) sheep model was used to investigate gestational low-level EC mixture exposure on the testes of F1 male offspring. Adult rams from ewes exposed to BTP 1 month before and throughout pregnancy had more seminiferous tubules with degeneration and depletion of elongating spermatids, indicating possible "recovery" from previously reported testicular dysgenesis syndrome-like phenotype in neonatal and pre-pubertal BTP lambs. Expression of transcription factors CREB1 (neonatal) and BCL11A and FOXP2 (pre-pubertal) were significantly higher in the BTP exposed testes, with no changes seen in adults. Increased CREB1, which is crucial for testes development and regulation of steroidogenic enzymes, could be an adaptive response to gestational EC exposure to facilitate the phenotypic recovery. Overall, this demonstrates that testicular effects from gestational exposure to low-level mixtures of ECs can last into adulthood, potentially impacting fertility and fecundity.
Identifiants
pubmed: 37209889
pii: S1382-6689(23)00094-7
doi: 10.1016/j.etap.2023.104152
pmc: PMC10457458
mid: NIHMS1926302
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104152Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030374
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Obes Rev. 2019 Jun;20(6):921-933
pubmed: 30756459
Int J Cancer. 1994 Oct 1;59(1):33-8
pubmed: 7927900
Environ Health Perspect. 2005 Apr;113(4):447-53
pubmed: 15811823
J Environ Monit. 2010 Aug 5;12(8):1582-93
pubmed: 20676422
Horm Res. 2002;57 Suppl 2:43
pubmed: 12065926
Reproduction. 2020 Apr;159(4):R173-R188
pubmed: 31786539
Trends Endocrinol Metab. 2009 Apr;20(3):139-45
pubmed: 19278865
Br Med J (Clin Res Ed). 1987 Nov 14;295(6608):1235-6
pubmed: 2891398
J Comput Biol. 2005 Oct;12(8):1047-64
pubmed: 16241897
Sci Rep. 2014 Jan 16;4:3731
pubmed: 24429544
Toxicol Appl Pharmacol. 2020 Oct 1;404:115151
pubmed: 32710958
Nat Rev Endocrinol. 2022 Mar;18(3):139-157
pubmed: 34912078
Lancet. 1985 Jan 12;1(8420):108
pubmed: 2857006
Hum Reprod. 2001 May;16(5):972-8
pubmed: 11331648
J Mol Endocrinol. 2018 Oct 1;:
pubmed: 30400066
Sci Total Environ. 1997 Oct 20;205(2-3):97-106
pubmed: 9372623
Environ Sci Technol. 2014 Sep 16;48(18):10843-9
pubmed: 25157505
Environ Pollut. 2013 Oct;181:262-70
pubmed: 23896644
Environ Health Perspect. 2000 Oct;108(10):961-6
pubmed: 11049816
Lancet. 1984 Aug 11;2(8398):330-2
pubmed: 6146873
Biochim Biophys Acta Gene Regul Mech. 2018 Dec;1861(12):1063-1075
pubmed: 30321752
Sci Total Environ. 2015 May 15;515-516:1-11
pubmed: 25682473
Toxicol Sci. 2009 Nov;112(1):153-63
pubmed: 19502547
Reproduction. 2011 Jan;141(1):37-46
pubmed: 20956578
Environ Toxicol Pharmacol. 2021 Aug;86:103670
pubmed: 33964400
J Androl. 2011 May-Jun;32(3):307-23
pubmed: 20966422
Toxicol Lett. 2017 Feb 5;267:21-31
pubmed: 28041982
Mol Cell Endocrinol. 2002 Feb 22;187(1-2):115-24
pubmed: 11988318
Nucleic Acids Res. 2019 Jul 2;47(W1):W212-W224
pubmed: 31114921
APMIS. 1998 Jan;106(1):232-8; discussion 238-9
pubmed: 9524584
Hum Reprod Update. 2023 Mar 1;29(2):157-176
pubmed: 36377604
J Environ Monit. 2002 Feb;4(1):142-8
pubmed: 11871695
Curr Opin Pharmacol. 2014 Dec;19:105-11
pubmed: 25244397
Environ Int. 2019 Mar;124:98-108
pubmed: 30641261
EMBO Rep. 2015 Apr;16(4):467-80
pubmed: 25700280
Endocrine. 2016 Jan;51(1):7-21
pubmed: 26271515
Reprod Biol Endocrinol. 2018 Nov 26;16(1):115
pubmed: 30474562
Cell Cycle. 2015;14(18):2905-13
pubmed: 26177380
Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):755-61
pubmed: 17272744
Toxicol Sci. 2018 Jan 1;161(1):76-86
pubmed: 29029336
Environ Toxicol Pharmacol. 2022 Aug;94:103913
pubmed: 35738462
Int J Androl. 2012 Jun;35(3):317-29
pubmed: 22150464
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Environ Health Perspect. 2005 Nov;113(11):1580-7
pubmed: 16263515
Hum Exp Toxicol. 2017 Jun;36(6):554-564
pubmed: 28539089
Front Endocrinol (Lausanne). 2021 Oct 07;12:706532
pubmed: 34690925
Crit Rev Toxicol. 2022 Mar;52(3):221-238
pubmed: 35894754
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):910-9
pubmed: 20865786
Best Pract Res Clin Endocrinol Metab. 2021 Sep;35(5):101512
pubmed: 34266749
J Microsc. 2006 Dec;224(Pt 3):213-32
pubmed: 17210054
Environ Toxicol. 2017 Aug;32(8):1977-1989
pubmed: 27539358
Environ Health Perspect. 2009 Dec;117(12):1839-46
pubmed: 20049201
Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1151-9
pubmed: 20447912
Fertil Steril. 1974 Jun;25(6):503-7
pubmed: 4835605
Oncogene. 2015 Apr 23;34(17):2239-50
pubmed: 24931163
Environ Int. 2011 Jan;37(1):226-47
pubmed: 20797791
Reproduction. 2022 Feb 03;163(2):119-131
pubmed: 35015698
J Environ Monit. 2009 Aug;11(8):1469-76
pubmed: 19657530
Reprod Toxicol. 2012 Sep;34(2):237-50
pubmed: 22677472