Chronic urticaria and the pathogenic role of mast cells.
Chronic spontaneous urticaria
FcεRI
IgE
MRGPRX2
Mast cells
Journal
Allergology international : official journal of the Japanese Society of Allergology
ISSN: 1440-1592
Titre abrégé: Allergol Int
Pays: England
ID NLM: 9616296
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
24
04
2023
accepted:
24
04
2023
medline:
28
6
2023
pubmed:
21
5
2023
entrez:
20
5
2023
Statut:
ppublish
Résumé
The signs and symptoms of chronic urticaria (CU) are caused by the activation and degranulation of skin mast cells (MCs). Recent studies have added to our understanding of how and why skin MCs are involved and different in CU. Also, novel and relevant mechanisms of MC activation in CU have been identified and characterized. Finally, the use of MC-targeted and MC mediator-specific treatments has helped to better define the role of the skin environment, the contribution of specific MC mediators, and the relevance of MC crosstalk with other cells in the pathogenesis of CU. Here, we review these recent findings and their impact on our understanding of CU, with a focus on chronic spontaneous urticaria (CSU). Also, we highlight open questions, issues of controversy, and unmet needs, and we suggest what studies should be performed moving forward.
Identifiants
pubmed: 37210251
pii: S1323-8930(23)00047-3
doi: 10.1016/j.alit.2023.05.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-368Informations de copyright
Copyright © 2023 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.