The Influence of Hyperparathyroidism Patient Profile on Quality of Life After Parathyroidectomy.
Journal
World journal of surgery
ISSN: 1432-2323
Titre abrégé: World J Surg
Pays: United States
ID NLM: 7704052
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
accepted:
05
05
2023
medline:
1
8
2023
pubmed:
21
5
2023
entrez:
21
5
2023
Statut:
ppublish
Résumé
Improvements in quality of life (QoL) after parathyroidectomy in patients with primary hyperparathyroidism (PHPT) is discussed. It has not been analyzed whether these improvements can be influenced by a specific socio-personal or clinical patient profile. to analyze QoL differences after parathyroidectomy and to determine a socio-personal and clinical profile that influences improvement after parathyroidectomy. A longitudinal prospective cohort study in patients with PHPT. SF-36 and PHPQOL questionnaires were completed by the patients. A comparative preoperatory analysis was carried out, at three and twelve months after surgery. Student's t test was used for the correlations. The size of the effect was assessed using G*Power software. A multivariate analysis was performed to evaluate the socio-personal and clinical variables affecting the improvement in QoL after surgery. Forty-eight patients were analyzed. Three months after surgery an improvement was found in physical function, general health, vitality, social function, emotional role, mental health and in the patient's declared health assessment. One year after the intervention a general improvement was observed, with a greater effect on mental health and declared health evolution. Patients with bone pain presented with a higher probability of improvement after surgery. Patients with prior psychological disease had a lower associated probability of an improvement and high levels of PTH related to a greater probability of improvement after surgery. There is an improvement in the QoL of PHPT patients after parathyroidectomy. Patients with bone pain and high PTH levels prior to the parathyroidectomy present with a greater probability of having a greater improvement in QoL after surgery.
Sections du résumé
BACKGROUND
Improvements in quality of life (QoL) after parathyroidectomy in patients with primary hyperparathyroidism (PHPT) is discussed. It has not been analyzed whether these improvements can be influenced by a specific socio-personal or clinical patient profile.
OBJECTIVES
to analyze QoL differences after parathyroidectomy and to determine a socio-personal and clinical profile that influences improvement after parathyroidectomy.
METHODS
A longitudinal prospective cohort study in patients with PHPT. SF-36 and PHPQOL questionnaires were completed by the patients. A comparative preoperatory analysis was carried out, at three and twelve months after surgery. Student's t test was used for the correlations. The size of the effect was assessed using G*Power software. A multivariate analysis was performed to evaluate the socio-personal and clinical variables affecting the improvement in QoL after surgery.
RESULTS
Forty-eight patients were analyzed. Three months after surgery an improvement was found in physical function, general health, vitality, social function, emotional role, mental health and in the patient's declared health assessment. One year after the intervention a general improvement was observed, with a greater effect on mental health and declared health evolution. Patients with bone pain presented with a higher probability of improvement after surgery. Patients with prior psychological disease had a lower associated probability of an improvement and high levels of PTH related to a greater probability of improvement after surgery.
CONCLUSIONS
There is an improvement in the QoL of PHPT patients after parathyroidectomy. Patients with bone pain and high PTH levels prior to the parathyroidectomy present with a greater probability of having a greater improvement in QoL after surgery.
Identifiants
pubmed: 37210692
doi: 10.1007/s00268-023-07066-6
pii: 10.1007/s00268-023-07066-6
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2197-2205Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s) under exclusive licence to Société Internationale de Chirurgie.
Références
Burney RE, Jones KR, Peterson M et al (1998) Surgical correction of primary hyperparathyroidism improves quality of life. Surgery 124:987–992
doi: 10.1016/S0039-6060(98)70039-X
pubmed: 9854573
Sheldon DG, Lee FT, Neil NJ et al (2002) Surgical treatment of hyperparathyroidism improves health-related quality of life. Arch Surg 137:1022–1028
doi: 10.1001/archsurg.137.9.1022
pubmed: 12215152
Coker LH, Rorie K, Cantley L et al (2005) Primary hyperparathyroidism, cognition, and health-related quality of life. Ann Surg 242:642–650
doi: 10.1097/01.sla.0000186337.83407.ec
pubmed: 16244536
pmcid: 1409861
Babińska D, Barczyński M, Stefaniak T et al (2012) Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism. Langenbeck’s Arch Surg 397:825–831
doi: 10.1007/s00423-011-0885-5
Ambrogini E, Cetani F, Cianferotti L (2007) Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trial. J Clin Endocrinol Metab 92:3114–3121
doi: 10.1210/jc.2007-0219
pubmed: 17535997
Bollerslev J, Jansson S, Mollerup CL et al (2007) Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial. J Clin Endocrinol Metab 92:1687–1692
doi: 10.1210/jc.2006-1836
pubmed: 17284629
Amstrup AK, Rejnmark L, Mosekilde L (2011) Patients with surgically cured primary hyperparathyroidism have a reduced quality of life compared with population-based healthy sex-, age-, and season-matched controls. Eur J Endocrinol 165:753–760
doi: 10.1530/EJE-11-0301
pubmed: 21862666
Caillard C, Sebag F, Mathonnet M et al (2007) Prospective evaluation of quality of life (SF-36v2) and nonspecific symptoms before and after cure of primary hyperparathyroidism (1-year follow-up). Surgery 141(2):153–160
doi: 10.1016/j.surg.2006.12.004
pubmed: 17263969
Leong KJ, Sam RC, Garnham AW (2010) Health-related quality of life improvement following surgical treatment of primary hyperparathyroidism in a United Kingdom population. Surgeon 8(1):5–8
doi: 10.1016/j.surge.2009.10.005
pubmed: 20222396
Weber T, Eberle J, Messelhäuser U et al (2013) Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism. JAMA Surg 148(2):109
doi: 10.1001/2013.jamasurg.316
pubmed: 23560281
Dulfer R, Geilvoet W, Morks A et al (2016) Impact of parathyroidectomy for primary hyperparathyroidism on quality of life: a case-control study using Short Form Health Survey 36. Head Neck 38(8):1213–1220
doi: 10.1002/hed.24499
pubmed: 27198205
Bannani S, Christou N, Guérin C et al (2018) Effect of parathyroidectomy on quality of life and non-specific symptoms in normocalcaemic primary hyperparathyroidism. Br J Surg 105(3):223–229
doi: 10.1002/bjs.10739
pubmed: 29405278
Blanchard C, Mathonnet M, Sebag F et al (2014) Quality of life is modestly improved in older patients with mild primary hyperparathyroidism postoperatively: results of a prospective multicenter study. Ann Surg Oncol 21(11):3534–3540
doi: 10.1245/s10434-014-3731-5
pubmed: 24823444
Webb SM, Puig-Domingo MM, Villabona C et al (2016) Validation of PHPQoL, a disease-specific quality-of-life questionnaire for patients with primary hyperparathyroidism. J Clin Endocrinol Metab 101(4):1571–1578
doi: 10.1210/jc.2015-3094
pubmed: 26771703
Papavramidis TS, Anagnostis P, Pliakos I et al (2022) The impact of age on quality of life and frailty outcomes after parathyroidectomy in patients with primary hyperparathyroidism. J Endocrinol Invest 45(4):797–802
doi: 10.1007/s40618-021-01710-5
pubmed: 34826129
Ejlsmark-Svensson H, Sikjaer T, Webb SM et al (2019) Health-related quality of life improves 1 year after parathyroidectomy in primary hyperparathyroidism: a prospective cohort study. Clin Endocrinol (Oxf) 90(1):184–191
doi: 10.1111/cen.13865
pubmed: 30267589
Febrero B, Ruiz-Manzanera JJ, Ros-Madrid I, et al. (2022) Quality of life, mood and sleep quality in patients with primary hyperparathyroidism. Impact of socio-personal and clinical profile. Ann Endocrinol (Paris) S0003-4266(22)00840-X
Livschitz J, Yen TWF, Evans DB, et al (2022) Long-term Quality of Life After Parathyroidectomy for Primary Hyperparathyroidism: a Systematic Review. JAMA Surg Online ahead of print
Bilezikian JP, Brandi ML, Eastell R et al (2014) Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J Clin Endocrinol Metab 99(10):3561–3569
doi: 10.1210/jc.2014-1413
pubmed: 25162665
pmcid: 5393490
The EuroQol Group (1999) EuroQol-a new facility for the measurement of healthrelated quality of life. Health Policy 16:199–208
Rowen D, Brazier J, Roberts J (2009) Mapping SF-36 onto the EQ-5D index: how reliable is the relationship? Health Qual Life Outcomes 7:27
doi: 10.1186/1477-7525-7-27
pubmed: 19335878
pmcid: 2683169
Wilhelm SM, Wang TS, Ruan DT et al (2016) The American Association of Endocrine Surgeons guidelines for definitive management of primary hyperparathyroidism. JAMA Surg 151(10):959–968
doi: 10.1001/jamasurg.2016.2310
pubmed: 27532368
Brito K, Edirimanne S, Eslick GG (2015) The extent of improvement of health-related quality of life as assessed by the SF36 and Pasieka scales after parathyroidectomy in patients with primary hyperparathyroidism: a systematic review and meta-analysis. Int J Surg 13:245–249
doi: 10.1016/j.ijsu.2014.12.004
pubmed: 25542340
Pasieka JL, Parsons L, Jones J (2009) The long-term benefit of parathyroidectomy in primary hyperparathyroidism: a 10-year prospective surgical outcome study. Surgery 146(6):1006–1013
doi: 10.1016/j.surg.2009.10.021
pubmed: 19958927
Webb SM, Puig-Domingo M, Villabona C et al (2013) Development of a new tool for assessing Health-Related Quality of Life in patients with primary hyperparathyroidism. Health Qual Life Outcomes 11(1):1
doi: 10.1186/1477-7525-11-97
Cheng SP, Lee JJ, Liu TP et al (2015) Quality of life after surgery or surveillance for asymptomatic primary hyperparathyroidism. Medicine 94(23):e931
doi: 10.1097/MD.0000000000000931
pubmed: 26061318
pmcid: 4616470
Rao DS, Phillips ER, Divine GW et al (2004) Randomized controlled clinical trial of surgery versus no surgery in patients with mild asymptomatic primary hyperparathyroidism. J Clin Endocrinol Metab 89(11):5415–5422
doi: 10.1210/jc.2004-0028
pubmed: 15531491
Pretorius M, Lundstam K, Hellström M et al (2021) Effects of parathyroidectomy on quality of life: 10 years of data from a prospective randomized controlled trial on primary hyperparathyroidism (the SIPH-Study). J Bone Miner Res 36(1):3–11
doi: 10.1002/jbmr.4199
pubmed: 33125769
Greutelaers B, Kullen K, Kollias J et al (2004) Pasieka Illness Questionnaire: its value in primary hyperparathyroidism. ANZ J Surg 74(3):112–115
doi: 10.1111/j.1445-2197.2004.02907.x
pubmed: 14996155
Weber T, Keller M, Hense I et al (2007) Effect of parathyroidectomy on quality of life and neuropsychological symptoms in primary hyperparathyroidism. World J Surg 31(6):1202–1209
doi: 10.1007/s00268-007-9006-6
pubmed: 17460812
Storvall S, Ryhänen EM, Heiskanen I et al (2017) Surgery significantly improves neurocognition, sleep, and blood pressure in primary hyperparathyroidism: a 3-year prospective follow-up study. Horm Metab Res 49(10):772–777
doi: 10.1055/s-0043-118347
pubmed: 28922677
Egan KR, Adler JT, Olson JE et al (2007) Parathyroidectomy for primary hyperparathyroidism in octogenarians and nonagenarians: a risk-benefit analysis. J Surg Res 140(2):194–198
doi: 10.1016/j.jss.2007.01.027
pubmed: 17509264
Burney RE, Jones KR, Christy B et al (1999) Health status improvement after surgical correction of primary hyperparathyroidism in patients with high and low preoperative calcium levels. Surgery 125(6):608–614
doi: 10.1016/S0039-6060(99)70224-2
pubmed: 10372026
Mihai R, Sadler GP (2008) Pasieka’s parathyroid symptoms scores correlate with SF-36 scores in patients undergoing surgery for primary hyperparathyroidism. World J Surg 32(5):807–814
doi: 10.1007/s00268-008-9509-9
pubmed: 18324348
Ramakant P, Verma AK, Chand G et al (2011) Salutary effect of parathyroidectomy on neuropsychiatric symptoms in patients with primary hyperparathyroidism: evaluation using PAS and SF-36v2 scoring systems. J Postgrad Med 57(2):96–101
doi: 10.4103/0022-3859.81859
pubmed: 21654129
Bargren AE, Repplinger D, Chen H et al (2011) Can Biochemical abnormalities predict symptomatology in patients with primary hyperparathyroidism? J Am Coll Surg 213(3):410–414
doi: 10.1016/j.jamcollsurg.2011.06.401
pubmed: 21723154
Roman SA, Sosa JA, Pietrzak RH et al (2011) The effects of serum calcium and parathyroid hormone changes on psychological and cognitive function in patients undergoing parathyroidectomy for primary hyperparathyroidism. Ann Surg 253(1):131–137
doi: 10.1097/SLA.0b013e3181f66720
pubmed: 21233611
Bagó AG, Dimitrov E, Saunders R et al (2009) Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. Neuroscience 162(1):128–147
doi: 10.1016/j.neuroscience.2009.04.054
pubmed: 19401215
Çermik TF, Kaya M, Uğur-Altun B et al (2007) Regional cerebral blood flow abnormalities in patients with primary hyperparathyroidism. Neuroradiology 49(4):379–385
doi: 10.1007/s00234-006-0198-5
pubmed: 17205311
Mjåland O, Normann E, Halvorsen E et al (2003) Regional cerebral blood flow in patients with primary hyperparathyroidism before and after successful parathyroidectomy. Br J Surg 90(6):732–737
doi: 10.1002/bjs.4131
pubmed: 12808624