A New Model-Based Approach for the Development of Freeze-Drying Cycles Using a Small-Scale Freeze-Dryer.

Freezing Freeze Drying / methods Temperature Technology, Pharmaceutical / methods Hot Temperature
Freeze-drying Mathematical modelling Micro freeze-dryer Optimization Scale-up

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
08 2023
Historique:
received: 12 04 2023
revised: 15 05 2023
accepted: 15 05 2023
medline: 17 7 2023
pubmed: 22 5 2023
entrez: 21 5 2023
Statut: ppublish

Résumé

This paper presents a model-based approach for the design of the primary drying stage of a freeze-drying process using a small-scale freeze-dryer (MicroFD® by Millrock Technology Inc.). Gravimetric tests, coupled with a model of the heat transfer to the product in the vials that account also for the heat exchange between the edge vials and the central vials, are used to infer the heat transfer coefficient from the shelf to the product in the vial (K

Identifiants

DOI: 10.1016/j.xphs.2023.05.007 PMID: 37211317
pubmed: 37211317
pii: S0022-3549(23)00194-6
doi: 10.1016/j.xphs.2023.05.007
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2176-2189

Informations de copyright

Copyright © 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest Millrock Technology Inc. has supported the study by loaning the MicroFD® used in this study to the research group of the Politecnico di Torino and by helping the researchers to solve practical issues related to the experimental investigation.

Auteurs

Ambra Massei (A)

Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, corso Duca degli Abruzzi 24, 10129, Torino.

Davide Fissore (D)

Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, corso Duca degli Abruzzi 24, 10129, Torino. Electronic address: davide.fissore@polito.it.

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Classifications MeSH

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questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › A New Model-Based Approach for the Development...
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