Purinergic P2X

Carotid body Heart failure Purinergic P2X3 receptors

Journal

Purinergic signalling

ISSN: 1573-9546

Titre abrégé: Purinergic Signal

Pays: Netherlands

ID NLM: 101250499

Informations de publication

Date de publication:
22 May 2023

Historique:

received: 27 04 2023

accepted: 11 05 2023

medline: 22 5 2023

pubmed: 22 5 2023

entrez: 21 5 2023

Statut: aheadofprint

Résumé

Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced carotid body chemoreflex function is strongly related to excessive sympathetic nerve activity and sleep-disordered breathing in heart failure. How to reduce the excitability of the carotid body is still scientifically challenging. Both clinical and experimental evidence have suggested that targeting purinergic receptors is of great potential to combat heart failure. In a recent study, Lataro et al. (Lataro et al. in Nat Commun 14:1725, 5) demonstrated that targeting purinergic P2X

Identifiants

DOI: 10.1007/s11302-023-09945-y PMID: 37211586

pubmed: 37211586

doi: 10.1007/s11302-023-09945-y

pii: 10.1007/s11302-023-09945-y

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : EFSD/Novo Nordisk Foundation Future Leaders Awards

ID : NNF22SA0081227

Organisme : Swedish Heart and Lung Foundation

ID : 20200326 and 20220264

Informations de copyright

Références

Iturriaga R, Alcayaga J, Chapleau MW, Somers VK (2021) Carotid body chemoreceptors: physiology, pathology, and implications for health and disease. Physiol Rev 101(3):1177–1235. https://doi.org/10.1152/physrev.00039.2019

doi: 10.1152/physrev.00039.2019 pubmed: 33570461 pmcid: 8526340

Niewinski P, Janczak D, Rucinski A, Tubek S, Engelman ZJ, Piesiak P, Jazwiec P, Banasiak W, Fudim M, Sobotka PA, Javaheri S, Hart EC, Paton JF, Ponikowski P (2017) Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study. Eur J Heart Fail 19(3):391–400. https://doi.org/10.1002/ejhf.641

doi: 10.1002/ejhf.641 pubmed: 27647775

Burnstock G (2017) Purinergic signaling in the cardiovascular system. Circ Res 120(1):207–228. https://doi.org/10.1161/CIRCRESAHA.116.309726

doi: 10.1161/CIRCRESAHA.116.309726 pubmed: 28057794

Wernly B, Zhou Z (2020) More purinergic receptors deserve attention as therapeutic targets for the treatment of cardiovascular disease. Am J Physiol Heart Circ Physiol 319(4):H723–H729. https://doi.org/10.1152/ajpheart.00417.2020

doi: 10.1152/ajpheart.00417.2020 pubmed: 32822211

Lataro RM, Moraes DJA, Gava FN, Omoto ACM, Silva CAA, Brognara F, Alflen L, Brazão V, Colato RP, de Prado JC, Ford AP, Salgado HC, Paton JFR (2023) P2X3 receptor antagonism attenuates the progression of heart failure. Nat Commun 14(1):1725. https://doi.org/10.1038/s41467-023-37077-9

doi: 10.1038/s41467-023-37077-9 pubmed: 36977675 pmcid: 10050083

Conde SV, Monteiro EC, Sacramento JF (2017) Purines and carotid body: new roles in pathological conditions. Front Pharmacol 12(8):913. https://doi.org/10.3389/fphar.2017.00913

doi: 10.3389/fphar.2017.00913

Fagerlund MJ, Kåhlin J, Ebberyd A, Schulte G, Mkrtchian S, Eriksson LI (2010) The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia. Anesthesiology 113(6):1270–1279. https://doi.org/10.1097/ALN.0b013e3181fac061

doi: 10.1097/ALN.0b013e3181fac061 pubmed: 20980909

Pijacka W, Moraes DJ, Ratcliffe LE, Nightingale AK, Hart EC, da Silva MP, Machado BH, McBryde FD, Abdala AP, Ford AP, Paton JF (2016) Purinergic receptors in the carotid body as a new drug target for controlling hypertension. Nat Med 22(10):1151–1159. https://doi.org/10.1038/nm.4173

doi: 10.1038/nm.4173 pubmed: 27595323 pmcid: 5750397

Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, Nurse CA (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol 537(Pt 3):667–677. https://doi.org/10.1111/j.1469-7793.2001.00667.x

doi: 10.1111/j.1469-7793.2001.00667.x pubmed: 11744746 pmcid: 2278999

Pubill D, Dayanithi G, Siatka C, Andrés M, Dufour MN, Guillon G, Mendre C (2001) ATP induces intracellular calcium increases and actin cytoskeleton disaggregation via P2x receptors. Cell Calcium 29(5):299–309. https://doi.org/10.1054/ceca.2000.0194

doi: 10.1054/ceca.2000.0194 pubmed: 11292387

Homma K, Niino Y, Hotta K, Oka K (2008) Ca(2+) influx through P2X receptors induces actin cytoskeleton reorganization by the formation of cofilin rods in neurites. Mol Cell Neurosci 37(2):261–270. https://doi.org/10.1016/j.mcn.2007.10.001

doi: 10.1016/j.mcn.2007.10.001 pubmed: 17993279

Sun C, Jiao T, Merkus D, Duncker DJ, Mustafa SJ, Zhou Z (2019) Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation. J Pharmacol Sci 141(1):64–69. https://doi.org/10.1016/j.jphs.2019.09.006

doi: 10.1016/j.jphs.2019.09.006 pubmed: 31640919 pmcid: 7418061

Zhou R, Dang X, Sprague RS, Mustafa SJ, Zhou Z (2020) Alteration of purinergic signaling in diabetes: focus on vascular function. J Mol Cell Cardiol 140:1–9. https://doi.org/10.1016/j.yjmcc.2020.02.004

doi: 10.1016/j.yjmcc.2020.02.004 pubmed: 32057736 pmcid: 7425578

Seol SH, Chung G (2022) Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): implication in burning mouth syndrome. J Dent Sci 17(1):8–13. https://doi.org/10.1016/j.jds.2021.06.007

doi: 10.1016/j.jds.2021.06.007 pubmed: 35028015